Aleve and Gastrointestinal inflammation - a phase IV clinical study of FDA data

Summary:

Gastrointestinal inflammation is found among people who take Aleve, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Aleve and have Gastrointestinal inflammation. It is created by eHealthMe based on reports of 61,515 people who have side effects when taking Aleve from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.



On Apr, 19, 2022

61,515 people reported to have side effects when taking Aleve.
Among them, 11 people (0.02%) have Gastrointestinal inflammation.


What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 63,507 Aleve users for its effectiveness, alternative drugs and more.

What is Gastrointestinal inflammation?

Gastrointestinal inflammation (inflammation of stomach and intestine) is found to be associated with 759 drugs and 492 conditions by eHealthMe.

Number of Aleve and Gastrointestinal inflammation reports submitted per year:

Could Aleve cause Gastrointestinal inflammation?

Time on Aleve when people have Gastrointestinal inflammation *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Gastrointestinal inflammation when taking Aleve *:

  • female: 81.82 %
  • male: 18.18 %

Age of people who have Gastrointestinal inflammation when taking Aleve *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 10 %
  • 50-59: 10 %
  • 60+: 80 %

Common drugs people take besides Aleve *:

  1. Celebrex: 4 people, 36.36%
  2. Ibuprofen: 3 people, 27.27%
  3. Pepcid: 2 people, 18.18%
  4. Naproxen Sodium: 2 people, 18.18%
  5. Metformin: 2 people, 18.18%
  6. Zoloft: 1 person, 9.09%
  7. Sinemet: 1 person, 9.09%
  8. Restasis: 1 person, 9.09%
  9. Prozac: 1 person, 9.09%
  10. Protonix: 1 person, 9.09%

Common side effects people have besides Gastrointestinal inflammation *:

  1. Colitis (inflammation of colon): 5 people, 45.45%
  2. Bone Disorder: 4 people, 36.36%
  3. Gastritis (inflammation of stomach): 4 people, 36.36%
  4. Diabetes: 4 people, 36.36%
  5. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 4 people, 36.36%
  6. Spinal Column Stenosis (narrowing of spinal column): 4 people, 36.36%
  7. Irritable Bowel Syndrome: 4 people, 36.36%
  8. Polyp: 3 people, 27.27%
  9. Flatulence (flatus expelled through the anus): 2 people, 18.18%
  10. Constipation: 2 people, 18.18%

Common conditions people have *:

  1. Carpal Tunnel Syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 4 people, 36.36%
  2. Diabetes: 3 people, 27.27%
  3. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 1 person, 9.09%
  4. Breast Cancer: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Aleve and have Gastrointestinal inflammation?

Check whether Gastrointestinal inflammation is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of Aleve:

Gastrointestinal inflammation treatments and more:

COVID vaccines that are related to Gastrointestinal inflammation:

How severe was Gastrointestinal inflammation and when was it recovered:

Expand to all the drugs that have ingredients of naproxen sodium:

Common drugs associated with Gastrointestinal inflammation:

All the drugs that are associated with Gastrointestinal inflammation:

Common conditions associated with Gastrointestinal inflammation:

All the conditions that are associated with Gastrointestinal inflammation:

How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium (the active ingredients of Aleve) and Aleve (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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