Aleve and Xerophthalmia - a phase IV clinical study of FDA data


Xerophthalmia is reported only by a few people who take Aleve.

The phase IV clinical study analyzes which people take Aleve and have Xerophthalmia. It is created by eHealthMe based on reports of 64,171 people who have side effects while taking Aleve from the FDA, and is updated regularly.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On May, 30, 2023

64,171 people reported to have side effects when taking Aleve.
Among them, 3 people (0.0%) have Xerophthalmia.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 66,205 Aleve users for its effectiveness, alternative drugs and more.

What is Xerophthalmia?

Xerophthalmia (eye fails to produce tears) is found to be associated with 900 drugs and 633 conditions by eHealthMe.

Number of Aleve and Xerophthalmia reports submitted per year:

Could Aleve cause Xerophthalmia?

Gender of people who have Xerophthalmia when taking Aleve *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Xerophthalmia when taking Aleve *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 66.67 %
  • 40-49: 0.0 %
  • 50-59: 33.33 %
  • 60+: 0.0 %

Common drugs people take besides Aleve *:

  1. Rebif: 2 people, 66.67%
  2. Zantac: 1 person, 33.33%
  3. Vitamin E: 1 person, 33.33%
  4. Serzone: 1 person, 33.33%
  5. Provigil: 1 person, 33.33%
  6. Plaquenil: 1 person, 33.33%
  7. Neurontin: 1 person, 33.33%
  8. Ibuprofen: 1 person, 33.33%
  9. Baclofen: 1 person, 33.33%

Common side effects people have besides Xerophthalmia *:

  1. Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 66.67%
  2. Lhermitte's Sign (an electrical sensation that runs down the back and into the limbs): 2 people, 66.67%
  3. Hypoaesthesia (reduced sense of touch or sensation): 2 people, 66.67%
  4. Diplopia (double vision): 2 people, 66.67%
  5. Ocular Hyperaemia (an abnormally large amount of blood in eye): 1 person, 33.33%
  6. Insomnia (sleeplessness): 1 person, 33.33%
  7. Hepatocellular Damage (liver damage): 1 person, 33.33%
  8. Hepatic Steatosis (fatty liver disease): 1 person, 33.33%
  9. Hepatic Enzyme Increased: 1 person, 33.33%
  10. Fatigue (feeling of tiredness): 1 person, 33.33%

Common conditions people have *:

  1. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 66.67%
  2. Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 33.33%

* Approximation only. Some reports may have incomplete information.

Do you take Aleve and have Xerophthalmia?

Check whether Xerophthalmia is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Xerophthalmia and when was it recovered:

Expand to all the drugs that have ingredients of naproxen sodium:

Alternative drugs to, pros and cons of Aleve:

Common Aleve side effects:

Browse all side effects of Aleve:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Xerophthalmia treatments and more:

COVID vaccines that are related to Xerophthalmia:

All the drugs that are associated with Xerophthalmia:

All the conditions that are associated with Xerophthalmia:

How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium (the active ingredients of Aleve) and Aleve (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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