Allopurinol and Anion gap decreased - a phase IV clinical study of FDA data


Anion gap decreased is found among people who take Allopurinol, especially for people who are male, 60+ old.

The phase IV clinical study analyzes which people take Allopurinol and have Anion gap decreased. It is created by eHealthMe based on reports of 164,051 people who have side effects when taking Allopurinol from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 03, 2022

164,051 people reported to have side effects when taking Allopurinol.
Among them, 9 people (0.01%) have Anion gap decreased.

What is Allopurinol?

Allopurinol has active ingredients of allopurinol. It is often used in gout. eHealthMe is studying from 166,532 Allopurinol users for its effectiveness, alternative drugs and more.

What is Anion gap decreased?

Anion gap decreased is found to be associated with 449 drugs and 168 conditions by eHealthMe.

Number of Allopurinol and Anion gap decreased reports submitted per year:

Could Allopurinol cause Anion gap decreased?

Gender of people who have Anion gap decreased when taking Allopurinol *:

  • female: 50 %
  • male: 50 %

Age of people who have Anion gap decreased when taking Allopurinol *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 25 %
  • 60+: 75 %

Common drugs people take besides Allopurinol *:

  1. Norvasc: 3 people, 33.33%
  2. Protonix: 3 people, 33.33%
  3. Colace: 3 people, 33.33%
  4. Zometa: 2 people, 22.22%
  5. Dexamethasone: 2 people, 22.22%
  6. Nicotine: 2 people, 22.22%
  7. Nexium: 2 people, 22.22%
  8. Neurontin: 2 people, 22.22%
  9. Metoprolol Tartrate: 2 people, 22.22%
  10. Marijuana: 2 people, 22.22%

Common side effects people have besides Anion gap decreased *:

  1. Blood Glucose Increased: 5 people, 55.56%
  2. Blood Bilirubin Increased: 3 people, 33.33%
  3. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 3 people, 33.33%
  4. Blood Calcium Decreased: 3 people, 33.33%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 33.33%
  6. Chest Pain: 3 people, 33.33%
  7. Anaemia (lack of blood): 3 people, 33.33%
  8. Thrombocytopenia (decrease of platelets in blood): 3 people, 33.33%
  9. Heart Rate Increased: 2 people, 22.22%
  10. Gingival Bleeding (bleeding gums): 2 people, 22.22%

Common conditions people have *:

  1. High Blood Pressure: 3 people, 33.33%
  2. Stress And Anxiety: 2 people, 22.22%
  3. Multiple Myeloma (cancer of the plasma cells): 2 people, 22.22%
  4. Diabetes: 2 people, 22.22%
  5. Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 1 person, 11.11%
  6. Ovarian Cancer (cancer of ovary): 1 person, 11.11%
  7. Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 1 person, 11.11%
  8. High Blood Cholesterol: 1 person, 11.11%
  9. Heart Rate Irregular: 1 person, 11.11%
  10. Dizziness: 1 person, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Allopurinol and have Anion gap decreased?

Check whether Anion gap decreased is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Anion gap decreased and when was it recovered:

Expand to all the drugs that have ingredients of allopurinol:

Alternative drugs to, pros and cons of Allopurinol:

Common Allopurinol side effects:

Browse all side effects of Allopurinol:

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Anion gap decreased treatments and more:

COVID vaccines that are related to Anion gap decreased:

All the drugs that are associated with Anion gap decreased:

All the conditions that are associated with Anion gap decreased:

How the study uses the data?

The study uses data from the FDA. It is based on allopurinol (the active ingredients of Allopurinol) and Allopurinol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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