Alprazolam and Hypernatraemia - a phase IV clinical study of FDA data


We study 126,091 people who have side effects when taking Alprazolam. Hypernatraemia is found, especially among people who are female, 60+ old, have been taking the drug for < 1 month, also take Pantoprazole and have High blood pressure.

The phase IV clinical study analyzes which people take Alprazolam and have Hypernatraemia. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 28, 2023

126,091 people reported to have side effects when taking Alprazolam.
Among them, 67 people (0.05%) have Hypernatraemia.

What is Alprazolam?

Alprazolam has active ingredients of alprazolam. It is used in stress and anxiety. Currently, eHealthMe is studying from 128,659 Alprazolam users.

What is Hypernatraemia?

Hypernatraemia (an abnormally high plasma concentration of sodium ions) is found to be associated with 1,351 drugs and 789 conditions by eHealthMe. Currently, we are studying 6,084 people who have Hypernatraemia.

Number of Alprazolam and Hypernatraemia reports submitted per year:

Could Alprazolam cause Hypernatraemia?

Time on Alprazolam when people have Hypernatraemia *:

  • < 1 month: 46.15 %
  • 1 - 6 months: 38.46 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 15.38 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Hypernatraemia when taking Alprazolam *:

  • female: 75.38 %
  • male: 24.62 %

Age of people who have Hypernatraemia when taking Alprazolam *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 3.17 %
  • 20-29: 0.0 %
  • 30-39: 7.94 %
  • 40-49: 14.29 %
  • 50-59: 20.63 %
  • 60+: 53.97 %

Common drugs people take besides Alprazolam *:

  1. Pantoprazole: 12 people, 17.91%
  2. Zyprexa: 10 people, 14.93%
  3. Vitamin D3: 8 people, 11.94%
  4. Remeron: 7 people, 10.45%
  5. Mirena: 5 people, 7.46%
  6. Heparin: 5 people, 7.46%
  7. Gilenya: 5 people, 7.46%
  8. Pepcid: 5 people, 7.46%
  9. Vistaril: 5 people, 7.46%
  10. Furosemide: 5 people, 7.46%

Common side effects people have besides Hypernatraemia *:

  1. Dehydration (dryness resulting from the removal of water): 23 people, 34.33%
  2. Hypokalemia (low potassium): 20 people, 29.85%
  3. Hyperchloraemia (an excess of chlorides in the blood): 14 people, 20.90%
  4. Confusional State: 12 people, 17.91%
  5. Metabolic Alkalosis (too much bicarbonate in the blood): 10 people, 14.93%
  6. Hypovolaemia (a decreased volume of circulating blood in the body): 10 people, 14.93%
  7. Hypotension (abnormally low blood pressure): 10 people, 14.93%
  8. Diabetes Insipidus - Nephrogenic (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function): 9 people, 13.43%
  9. Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 9 people, 13.43%
  10. Hyperaldosteronism: 9 people, 13.43%

Common conditions people have *:

  1. Depression: 13 people, 19.40%
  2. High Blood Pressure: 13 people, 19.40%
  3. Bipolar Disorder (mood disorder): 10 people, 14.93%
  4. Pain: 7 people, 10.45%
  5. Diabetes Insipidus - Nephrogenic (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function): 7 people, 10.45%
  6. Gastrointestinal Motility Disorder (abnormal intestinal contractions): 7 people, 10.45%
  7. Insomnia (sleeplessness): 6 people, 8.96%
  8. Migraine (headache): 5 people, 7.46%
  9. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 7.46%
  10. Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 5 people, 7.46%

* Approximation only. Some reports may have incomplete information.

Do you take Alprazolam and have Hypernatraemia?

Check whether Hypernatraemia is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Alprazolam side effects by duration, gender and age:

Hypernatraemia treatments and more:

Common drugs associated with Hypernatraemia:

All the drugs that are associated with Hypernatraemia:

Common conditions associated with Hypernatraemia:

All the conditions that are associated with Hypernatraemia:

How the study uses the data?

The study uses data from the FDA. It is based on alprazolam (the active ingredients of Alprazolam) and Alprazolam (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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