Ambien and Quincke's disease - a phase IV clinical study of FDA data


Quincke's disease is found among people who take Ambien, especially for people who are female, 30-39 old.

The phase IV clinical study analyzes which people take Ambien and have Quincke's disease. It is created by eHealthMe based on reports of 83,215 people who have side effects when taking Ambien from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Jan, 29, 2023

83,215 people reported to have side effects when taking Ambien.
Among them, 66 people (0.08%) have Quincke's disease.

What is Ambien?

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 89,833 Ambien users for its effectiveness, alternative drugs and more.

What is Quincke's disease?

Quincke's disease (a form of localized swelling of the deeper layers of the skin and fatty tissues beneath the skin) is found to be associated with 949 drugs and 468 conditions by eHealthMe.

Number of Ambien and Quincke's disease reports submitted per year:

Could Ambien cause Quincke's disease?

Gender of people who have Quincke's disease when taking Ambien *:

  • female: 88.46 %
  • male: 11.54 %

Age of people who have Quincke's disease when taking Ambien *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 17.65 %
  • 30-39: 38.24 %
  • 40-49: 26.47 %
  • 50-59: 11.76 %
  • 60+: 5.88 %

Common drugs people take besides Ambien *:

  1. Firazyr: 31 people, 46.97%
  2. Epipen: 14 people, 21.21%
  3. Sterile Water: 13 people, 19.70%
  4. Zantac: 13 people, 19.70%
  5. Vitamin D3: 12 people, 18.18%
  6. Kalbitor: 10 people, 15.15%
  7. Singulair: 10 people, 15.15%
  8. Synthroid: 10 people, 15.15%
  9. Vitamin B12: 9 people, 13.64%
  10. Xanax: 9 people, 13.64%

Common side effects people have besides Quincke's disease *:

  1. Stress And Anxiety: 7 people, 10.61%
  2. Drug Ineffective: 7 people, 10.61%
  3. Breathing Difficulty: 4 people, 6.06%
  4. Overdose: 4 people, 6.06%
  5. Completed Suicide (act of taking one's own life): 4 people, 6.06%
  6. Tooth Abscess (pus formation in tooth): 4 people, 6.06%
  7. Pneumonia: 3 people, 4.55%
  8. Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 3 people, 4.55%
  9. Nausea (feeling of having an urge to vomit): 3 people, 4.55%
  10. Pain: 3 people, 4.55%

Common conditions people have *:

  1. Immune System Disorder: 13 people, 19.70%
  2. Pain: 6 people, 9.09%
  3. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 7.58%
  4. Abdominal Pain: 4 people, 6.06%
  5. Asthma: 4 people, 6.06%
  6. Constipation: 4 people, 6.06%
  7. Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 3 people, 4.55%
  8. Stress And Anxiety: 3 people, 4.55%
  9. Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 2 people, 3.03%
  10. Depression: 2 people, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Ambien and have Quincke's disease?

Check whether Quincke's disease is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Quincke's disease and when was it recovered:

Expand to all the drugs that have ingredients of zolpidem tartrate:

Alternative drugs to, pros and cons of Ambien:

Common Ambien side effects:

Browse all side effects of Ambien:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Quincke's disease treatments and more:

COVID vaccines that are related to Quincke's disease:

Common drugs associated with Quincke's disease:

All the drugs that are associated with Quincke's disease:

Common conditions associated with Quincke's disease:

All the conditions that are associated with Quincke's disease:

How the study uses the data?

The study uses data from the FDA. It is based on zolpidem tartrate (the active ingredients of Ambien) and Ambien (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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