Amiodarone hydrochloride and Purpura - a phase IV clinical study of FDA data


We study 8,364 people who have side effects when taking Amiodarone hydrochloride. Purpura is found, especially among people who are female, 60+ old, have been taking the drug for < 1 month, also take Enalapril maleate and have Acute myocardial infarction.

The phase IV clinical study analyzes which people take Amiodarone hydrochloride and have Purpura. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 28, 2023

8,364 people reported to have side effects when taking Amiodarone hydrochloride.
Among them, 10 people (0.12%) have Purpura.

What is Amiodarone hydrochloride?

Amiodarone hydrochloride has active ingredients of amiodarone hydrochloride. It is used in atrial fibrillation/flutter. Currently, eHealthMe is studying from 9,107 Amiodarone hydrochloride users.

What is Purpura?

Purpura (purplish discoloration of the skin) is found to be associated with 1,843 drugs and 1,470 conditions by eHealthMe. Currently, we are studying 10,321 people who have Purpura.

Number of Amiodarone hydrochloride and Purpura reports submitted per year:

Could Amiodarone hydrochloride cause Purpura?

Time on Amiodarone hydrochloride when people have Purpura *:

  • < 1 month: 50 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Purpura when taking Amiodarone hydrochloride *:

  • female: 55.56 %
  • male: 44.44 %

Age of people who have Purpura when taking Amiodarone hydrochloride *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 11.11 %
  • 60+: 88.89 %

Common drugs people take besides Amiodarone hydrochloride *:

  1. Amlodipine: 2 people, 20.00%
  2. Apixaban: 2 people, 20.00%
  3. Atenolol: 2 people, 20.00%
  4. Ramipril: 2 people, 20.00%
  5. Cefotaxime Sodium: 2 people, 20.00%
  6. Clindamycin Hydrochloride: 2 people, 20.00%
  7. Clopidogrel Bisulfate: 2 people, 20.00%
  8. Enalapril Maleate: 2 people, 20.00%
  9. Vitamin E: 1 person, 10.00%
  10. Folic Acid: 1 person, 10.00%

Common side effects people have besides Purpura *:

  1. White Blood Cell Count Decreased: 2 people, 20.00%
  2. Rashes (redness): 2 people, 20.00%
  3. Papule: 2 people, 20.00%
  4. Pain In Extremity: 2 people, 20.00%
  5. Cutaneous Vasculitis (an inflammatory process affecting the vessel wall that leads to its damage): 2 people, 20.00%
  6. Eosinophil Count Increased: 2 people, 20.00%
  7. Fatigue (feeling of tiredness): 2 people, 20.00%
  8. Haematuria (presence of blood in urine): 1 person, 10.00%
  9. Burning Sensation: 1 person, 10.00%
  10. Dermatitis Exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss): 1 person, 10.00%

Common conditions people have *:

  1. Acute Myocardial Infarction (acute heart attack): 2 people, 20.00%
  2. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 10.00%
  3. Sleep Disorder: 1 person, 10.00%
  4. Sepsis (a severe blood infection that can lead to organ failure and death): 1 person, 10.00%
  5. Pneumonia: 1 person, 10.00%
  6. Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 10.00%
  7. High Blood Pressure: 1 person, 10.00%
  8. Gastrointestinal Disorder (functional problems of gastrointestinal tract): 1 person, 10.00%
  9. Fever: 1 person, 10.00%
  10. Enlarged Prostate: 1 person, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Amiodarone hydrochloride and have Purpura?

Check whether Purpura is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Amiodarone hydrochloride side effects by duration, gender and age:

Purpura treatments and more:

Common drugs associated with Purpura:

All the drugs that are associated with Purpura:

Common conditions associated with Purpura:

All the conditions that are associated with Purpura:

How the study uses the data?

The study uses data from the FDA. It is based on amiodarone hydrochloride (the active ingredients of Amiodarone hydrochloride) and Amiodarone hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: