Amitriptyline hydrochloride and Arthritis - a phase IV clinical study of FDA data


Arthritis is found among people who take Amitriptyline hydrochloride, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years.

The phase IV clinical study analyzes which people take Amitriptyline hydrochloride and have Arthritis. It is created by eHealthMe based on reports of 9,745 people who have side effects when taking Amitriptyline hydrochloride from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On Jun, 16, 2022

9,745 people reported to have side effects when taking Amitriptyline hydrochloride.
Among them, 86 people (0.88%) have Arthritis.

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 12,879 Amitriptyline hydrochloride users for its effectiveness, alternative drugs and more.

What is Arthritis?

Arthritis (form of joint disorder that involves inflammation of one or more joints) is found to be associated with 2,610 drugs and 2,089 conditions by eHealthMe.

Number of Amitriptyline hydrochloride and Arthritis reports submitted per year:

Could Amitriptyline hydrochloride cause Arthritis?

Time on Amitriptyline hydrochloride when people have Arthritis *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Arthritis when taking Amitriptyline hydrochloride *:

  • female: 77.78 %
  • male: 22.22 %

Age of people who have Arthritis when taking Amitriptyline hydrochloride *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 1.67 %
  • 30-39: 8.33 %
  • 40-49: 23.33 %
  • 50-59: 15.0 %
  • 60+: 51.67 %

Common drugs people take besides Amitriptyline hydrochloride *:

  1. Fosamax: 31 people, 36.05%
  2. Elavil: 22 people, 25.58%
  3. Humira: 20 people, 23.26%
  4. Enbrel: 20 people, 23.26%
  5. Simponi: 19 people, 22.09%
  6. Xeljanz: 19 people, 22.09%
  7. Orencia: 19 people, 22.09%
  8. Imuran: 16 people, 18.60%
  9. Lyrica: 14 people, 16.28%
  10. Celebrex: 14 people, 16.28%

Common side effects people have besides Arthritis *:

  1. Joint Pain: 49 people, 56.98%
  2. Nausea (feeling of having an urge to vomit): 44 people, 51.16%
  3. Pain In Extremity: 43 people, 50.00%
  4. Fatigue (feeling of tiredness): 41 people, 47.67%
  5. Stress And Anxiety: 37 people, 43.02%
  6. Breathing Difficulty: 35 people, 40.70%
  7. Pain: 33 people, 38.37%
  8. Headache (pain in head): 31 people, 36.05%
  9. Diarrhea: 27 people, 31.40%
  10. Fall: 27 people, 31.40%

Common conditions people have *:

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 21 people, 24.42%
  2. Osteoporosis (bones weak and more likely to break): 19 people, 22.09%
  3. Osteopenia (a condition where bone mineral density is lower than normal): 17 people, 19.77%
  4. High Blood Pressure: 11 people, 12.79%
  5. Sleep Disorder: 9 people, 10.47%
  6. Pain: 7 people, 8.14%
  7. Cystitis Interstitial (unknown cause characterized by bladder pain): 5 people, 5.81%
  8. Metastases To Bone (cancer spreads to bone): 5 people, 5.81%
  9. Prostate Cancer: 5 people, 5.81%
  10. Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 5.81%

* Approximation only. Some reports may have incomplete information.

Do you take Amitriptyline hydrochloride and have Arthritis?

Check whether Arthritis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of Amitriptyline hydrochloride:

Arthritis treatments and more:

COVID vaccines that are related to Arthritis:

How severe was Arthritis and when was it recovered:

Expand to all the drugs that have ingredients of amitriptyline hydrochloride:

Common drugs associated with Arthritis:

All the drugs that are associated with Arthritis:

Common conditions associated with Arthritis:

All the conditions that are associated with Arthritis:

How the study uses the data?

The study uses data from the FDA. It is based on amitriptyline hydrochloride (the active ingredients of Amitriptyline hydrochloride) and Amitriptyline hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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