Amitriptyline hydrochloride and Unintended pregnancy - a phase IV clinical study of FDA data


Unintended pregnancy is found among people who take Amitriptyline hydrochloride, especially for people who are female, 20-29 old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Amitriptyline hydrochloride and have Unintended pregnancy. It is created by eHealthMe based on reports of 11,507 people who have side effects when taking Amitriptyline hydrochloride from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Dec, 08, 2022

11,507 people reported to have side effects when taking Amitriptyline hydrochloride.
Among them, 8 people (0.07%) have Unintended pregnancy.

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 14,726 Amitriptyline hydrochloride users for its effectiveness, alternative drugs and more.

What is Unintended pregnancy?

Unintended pregnancy (unwanted pregnancies as well as those that are mistimed) is found to be associated with 691 drugs and 361 conditions by eHealthMe.

Number of Amitriptyline hydrochloride and Unintended pregnancy reports submitted per year:

Could Amitriptyline hydrochloride cause Unintended pregnancy?

Time on Amitriptyline hydrochloride when people have Unintended pregnancy *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 66.67 %
  • 6 - 12 months: 33.33 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Unintended pregnancy when taking Amitriptyline hydrochloride *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Unintended pregnancy when taking Amitriptyline hydrochloride *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 20 %
  • 20-29: 80 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Common drugs people take besides Amitriptyline hydrochloride *:

  1. Nexplanon: 4 people, 50.00%
  2. Nuvaring: 2 people, 25.00%
  3. Mirena: 2 people, 25.00%
  4. Tramadol Hydrochloride: 1 person, 12.50%
  5. Sumatriptan: 1 person, 12.50%
  6. Nitrofurantoin: 1 person, 12.50%
  7. Naproxen: 1 person, 12.50%
  8. Implanon: 1 person, 12.50%
  9. Fluoxetine: 1 person, 12.50%
  10. Erythromycin: 1 person, 12.50%

Common side effects people have besides Unintended pregnancy *:

  1. Abortion Spontaneous (naturally occurring miscarriage): 4 people, 50.00%
  2. Nausea (feeling of having an urge to vomit): 3 people, 37.50%
  3. Dysmenorrhea (painful menstruation): 3 people, 37.50%
  4. Vaginal Bleeding Between Periods: 3 people, 37.50%
  5. Menstruation Delayed (late menstruation cycle): 3 people, 37.50%
  6. Heavy Or Prolong Menstrual Bleeding: 3 people, 37.50%
  7. Chest Pain: 2 people, 25.00%
  8. Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 25.00%
  9. Cardiac Failure Congestive: 2 people, 25.00%
  10. Viral Upper Respiratory Tract Infection: 2 people, 25.00%

Common conditions people have *:

  1. Birth Control: 7 people, 87.50%
  2. Back Pain: 2 people, 25.00%
  3. Bacterial Infection: 2 people, 25.00%
  4. Urinary Tract Infection: 1 person, 12.50%
  5. Depressed Mood: 1 person, 12.50%
  6. Adnexa Uteri Pain: 1 person, 12.50%
  7. Anaemia (lack of blood): 1 person, 12.50%
  8. Cystitis Interstitial (unknown cause characterized by bladder pain): 1 person, 12.50%
  9. Dizziness: 1 person, 12.50%
  10. Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 1 person, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Amitriptyline hydrochloride and have Unintended pregnancy?

Check whether Unintended pregnancy is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Unintended pregnancy and when was it recovered:

Expand to all the drugs that have ingredients of amitriptyline hydrochloride:

Alternative drugs to, pros and cons of Amitriptyline hydrochloride:

Common Amitriptyline hydrochloride side effects:

Browse all side effects of Amitriptyline hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Unintended pregnancy treatments and more:

COVID vaccines that are related to Unintended pregnancy:

Common drugs associated with Unintended pregnancy:

All the drugs that are associated with Unintended pregnancy:

Common conditions associated with Unintended pregnancy:

All the conditions that are associated with Unintended pregnancy:

How the study uses the data?

The study uses data from the FDA. It is based on amitriptyline hydrochloride (the active ingredients of Amitriptyline hydrochloride) and Amitriptyline hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: