Amlodipine and Dupuytren's contracture - a phase IV clinical study of FDA data


Dupuytren's contracture is found among people who take Amlodipine, especially for people who are male, 50-59 old, have been taking the drug for 2 - 5 years.

The phase IV clinical study analyzes which people take Amlodipine and have Dupuytren's contracture. It is created by eHealthMe based on reports of 252,343 people who have side effects when taking Amlodipine from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On Jun, 01, 2022

252,343 people reported to have side effects when taking Amlodipine.
Among them, 12 people (0.0%) have Dupuytren's contracture.

What is Amlodipine?

Amlodipine has active ingredients of amlodipine besylate. It is often used in high blood pressure. eHealthMe is studying from 258,413 Amlodipine users for its effectiveness, alternative drugs and more.

What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 429 drugs and 189 conditions by eHealthMe.

Number of Amlodipine and Dupuytren's contracture reports submitted per year:

Could Amlodipine cause Dupuytren's contracture?

Time on Amlodipine when people have Dupuytren's contracture *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Dupuytren's contracture when taking Amlodipine *:

  • female: 33.33 %
  • male: 66.67 %

Age of people who have Dupuytren's contracture when taking Amlodipine *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 62.5 %
  • 60+: 37.5 %

Common drugs people take besides Amlodipine *:

  1. Humira: 4 people, 33.33%
  2. Asa: 2 people, 16.67%
  3. Trileptal: 2 people, 16.67%
  4. Metformin: 2 people, 16.67%
  5. Ocrevus: 2 people, 16.67%
  6. Potassium: 2 people, 16.67%
  7. Sertraline: 2 people, 16.67%
  8. Clopidogrel: 2 people, 16.67%
  9. Xiaflex: 2 people, 16.67%
  10. Carafate: 2 people, 16.67%

Common side effects people have besides Dupuytren's contracture *:

  1. Pain In Extremity: 5 people, 41.67%
  2. Drug Ineffective: 3 people, 25.00%
  3. Fall: 3 people, 25.00%
  4. Wound Infection: 2 people, 16.67%
  5. Muscle Spasms (muscle contraction): 2 people, 16.67%
  6. Carpal Tunnel Syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 2 people, 16.67%
  7. Depression: 2 people, 16.67%
  8. Dysgraphia (impaired ability to learn to write): 2 people, 16.67%
  9. Gastric Ulcer (stomach ulcer): 2 people, 16.67%
  10. Hoarseness Or Changing Voice: 2 people, 16.67%

Common conditions people have *:

  1. Back Pain: 4 people, 33.33%
  2. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 25.00%
  3. Psoriasis (immune-mediated disease that affects the skin): 3 people, 25.00%
  4. Depression: 2 people, 16.67%
  5. Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 16.67%
  6. Pain: 2 people, 16.67%
  7. Neck Pain: 2 people, 16.67%
  8. Muscle Spasms (muscle contraction): 2 people, 16.67%
  9. Blood Potassium Decreased: 2 people, 16.67%
  10. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Amlodipine and have Dupuytren's contracture?

Check whether Dupuytren's contracture is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Alternative drugs to, pros and cons of Amlodipine:

Dupuytren's contracture treatments and more:

COVID vaccines that are related to Dupuytren's contracture:

How severe was Dupuytren's contracture and when was it recovered:

Expand to all the drugs that have ingredients of amlodipine besylate:

Common drugs associated with Dupuytren's contracture:

All the drugs that are associated with Dupuytren's contracture:

All the conditions that are associated with Dupuytren's contracture:

How the study uses the data?

The study uses data from the FDA. It is based on amlodipine besylate (the active ingredients of Amlodipine) and Amlodipine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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