Amlodipine and Z-e syndrome - a phase IV clinical study of FDA data


Z-e syndrome is reported only by a few people who take Amlodipine.

The phase IV clinical study analyzes which people take Amlodipine and have Z-e syndrome. It is created by eHealthMe based on reports of 285,218 people who have side effects while taking Amlodipine from the FDA, and is updated regularly.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Mar, 24, 2023

285,218 people reported to have side effects when taking Amlodipine.
Among them, 5 people (0.0%) have Z-e syndrome.

What is Amlodipine?

Amlodipine has active ingredients of amlodipine besylate. It is often used in high blood pressure. eHealthMe is studying from 292,190 Amlodipine users for its effectiveness, alternative drugs and more.

What is Z-e syndrome?

Z-e syndrome (increased production of the hormone gastrin from a small tumour of pancreas) is found to be associated with 153 drugs and 167 conditions by eHealthMe.

Number of Amlodipine and Z-e syndrome reports submitted per year:

Could Amlodipine cause Z-e syndrome?

Gender of people who have Z-e syndrome when taking Amlodipine *:

  • female: 20 %
  • male: 80 %

Age of people who have Z-e syndrome when taking Amlodipine *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 80 %
  • 60+: 20 %

Common drugs people take besides Amlodipine *:

  1. Pantoprazole: 2 people, 40.00%
  2. Vitamin D3: 1 person, 20.00%
  3. Novolog: 1 person, 20.00%
  4. Calcium Citrate: 1 person, 20.00%
  5. Carafate: 1 person, 20.00%
  6. Coconut Oil: 1 person, 20.00%
  7. Coumadin: 1 person, 20.00%
  8. Fish Oil: 1 person, 20.00%
  9. Imodium A-D: 1 person, 20.00%
  10. Janumet: 1 person, 20.00%

Common side effects people have besides Z-e syndrome *:

  1. Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 4 people, 80.00%
  2. Hypokalemia (low potassium): 3 people, 60.00%
  3. Diarrhea: 2 people, 40.00%
  4. Haemoglobin Decreased: 2 people, 40.00%
  5. Gastric Ulcer (stomach ulcer): 2 people, 40.00%
  6. Circulatory Collapse: 2 people, 40.00%
  7. Abdominal Pain: 2 people, 40.00%
  8. Confusional State: 1 person, 20.00%
  9. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 20.00%
  10. Death: 1 person, 20.00%

Common conditions people have *:

  1. Gastrointestinal Inflammation (inflammation of stomach and intestine): 3 people, 60.00%
  2. Thrombosis (formation of a blood clot inside a blood vessel): 1 person, 20.00%
  3. Neoplasm Progression (growth of tumour): 1 person, 20.00%
  4. Malignant Neoplasm Of Islets Of Langerhans (cancer tumour of pancreas): 1 person, 20.00%
  5. Liver Transplant Rejection (failure of liver transplant): 1 person, 20.00%
  6. Joint Pain: 1 person, 20.00%
  7. High Blood Cholesterol: 1 person, 20.00%
  8. Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 1 person, 20.00%
  9. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 20.00%
  10. Gastric Ulcer (stomach ulcer): 1 person, 20.00%

* Approximation only. Some reports may have incomplete information.

Do you take Amlodipine and have Z-e syndrome?

Check whether Z-e syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Z-e syndrome and when was it recovered:

Expand to all the drugs that have ingredients of amlodipine besylate:

Alternative drugs to, pros and cons of Amlodipine:

Common Amlodipine side effects:

Browse all side effects of Amlodipine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Z-e syndrome treatments and more:

COVID vaccines that are related to Z-e syndrome:

All the drugs that are associated with Z-e syndrome:

All the conditions that are associated with Z-e syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on amlodipine besylate (the active ingredients of Amlodipine) and Amlodipine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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