Aricept and Leukocytosis - a phase IV clinical study of FDA data

Summary:

Leukocytosis is found among people who take Aricept, especially for people who are female, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Aricept and have Leukocytosis. It is created by eHealthMe based on reports of 22,849 people who have side effects when taking Aricept from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Mar, 28, 2023

22,849 people reported to have side effects when taking Aricept.
Among them, 42 people (0.18%) have Leukocytosis.

What is Aricept?

Aricept has active ingredients of donepezil hydrochloride. It is often used in alzheimer's disease. eHealthMe is studying from 23,864 Aricept users for its effectiveness, alternative drugs and more.

What is Leukocytosis?

Leukocytosis (increased white blood cells) is found to be associated with 2,251 drugs and 1,734 conditions by eHealthMe.

Number of Aricept and Leukocytosis reports submitted per year:

Time on Aricept when people have Leukocytosis *:

Gender of people who have Leukocytosis when taking Aricept *:

female: 55 %
male: 45 %

Age of people who have Leukocytosis when taking Aricept *:

Common drugs people take besides Aricept *:

Common side effects people have besides Leukocytosis *:

Anaemia (lack of blood): 15 people, 35.71%
Fever: 15 people, 35.71%
Weakness: 13 people, 30.95%
Dehydration (dryness resulting from the removal of water): 13 people, 30.95%
Nausea (feeling of having an urge to vomit): 12 people, 28.57%
Fatigue (feeling of tiredness): 11 people, 26.19%
Hypotension (abnormally low blood pressure): 11 people, 26.19%
Nausea And Vomiting: 11 people, 26.19%
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 11 people, 26.19%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 10 people, 23.81%

Common conditions people have *:

Type 2 Diabetes: 7 people, 16.67%
Pain: 6 people, 14.29%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 4 people, 9.52%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 9.52%
High Blood Pressure: 3 people, 7.14%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 7.14%
Burkitt Lymphoma (cancer of the lymphatic system): 3 people, 7.14%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 4.76%
Stress And Anxiety: 2 people, 4.76%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Aricept and have Leukocytosis?

Check whether Leukocytosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Khan A, Yasin Z, "Hyperleukocytosis Caused By Neulasta Complicated By Leukostasis Versus Asymptomatic Uncomplicated Hyperleukocytosis In AML. Two Cases and When To Leukapherese.", Am Soc Hematology, 2017 Jan .

Related studies

How severe was Leukocytosis and when was it recovered:

Leukocytosis in Aricept

Expand to all the drugs that have ingredients of donepezil hydrochloride:

Leukocytosis and drugs with ingredients of donepezil hydrochloride (79 reports)

Alternative drugs to, pros and cons of Aricept:

Aricept (23,864 reports)

Common Aricept side effects:

Weakness: 1,264 reports
Fatigue (feeling of tiredness): 1,202 reports
Dizziness: 1,008 reports
Drowsiness: 901 reports
Diarrhea: 878 reports

Browse all side effects of Aricept:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Leukocytosis treatments and more:

Leukocytosis (20,607 reports)

COVID vaccines that are related to Leukocytosis:

Common drugs associated with Leukocytosis:

All the drugs that are associated with Leukocytosis:

Leukocytosis (2,251 drugs)

Common conditions associated with Leukocytosis:

All the conditions that are associated with Leukocytosis:

Leukocytosis (1,734 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on donepezil hydrochloride (the active ingredients of Aricept) and Aricept (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.