Aripiprazole and Cholinergic syndrome - a phase IV clinical study of FDA data


Cholinergic syndrome is found among people who take Aripiprazole, especially for people who are male, 10-19 old.

The phase IV clinical study analyzes which people take Aripiprazole and have Cholinergic syndrome. It is created by eHealthMe based on reports of 29,778 people who have side effects when taking Aripiprazole from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 06, 2023

29,778 people reported to have side effects when taking Aripiprazole.
Among them, 25 people (0.08%) have Cholinergic syndrome.

What is Aripiprazole?

Aripiprazole has active ingredients of aripiprazole. It is often used in depression. eHealthMe is studying from 29,998 Aripiprazole users for its effectiveness, alternative drugs and more.

What is Cholinergic syndrome?

Cholinergic syndrome (symptoms of increased cholinergic stimulation) is found to be associated with 275 drugs and 133 conditions by eHealthMe.

Number of Aripiprazole and Cholinergic syndrome reports submitted per year:

Could Aripiprazole cause Cholinergic syndrome?

Gender of people who have Cholinergic syndrome when taking Aripiprazole *:

  • female: 20 %
  • male: 80 %

Age of people who have Cholinergic syndrome when taking Aripiprazole *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 70.83 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 20.83 %
  • 60+: 8.33 %

Common drugs people take besides Aripiprazole *:

  1. Olanzapine: 16 people, 64.00%
  2. Diazepam: 16 people, 64.00%
  3. Amisulpride: 16 people, 64.00%
  4. Mirtazapine: 14 people, 56.00%
  5. Clozaril: 13 people, 52.00%
  6. Clozapine: 9 people, 36.00%
  7. Simvastatin: 5 people, 20.00%
  8. Levothyroxine Sodium: 5 people, 20.00%
  9. Depakote: 5 people, 20.00%
  10. Stelazine: 3 people, 12.00%

Common side effects people have besides Cholinergic syndrome *:

  1. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 24 people, 96.00%
  2. Diarrhea: 19 people, 76.00%
  3. White Blood Cell Count Decreased: 19 people, 76.00%
  4. Antisocial Behavior: 17 people, 68.00%
  5. Agitation (state of anxiety or nervous excitement): 17 people, 68.00%
  6. Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 16 people, 64.00%
  7. Hyperhidrosis (abnormally increased sweating): 15 people, 60.00%
  8. Hypomania (a mild form of mania, marked by elation and hyperactivity): 14 people, 56.00%
  9. White Blood Cell Count Increased: 14 people, 56.00%
  10. Disinhibition (loss of inhibition): 14 people, 56.00%

Common conditions people have *:

  1. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 22 people, 88.00%
  2. Psychotic Disorder: 9 people, 36.00%
  3. Depressed Mood: 9 people, 36.00%
  4. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 3 people, 12.00%
  5. Mania (a state of abnormally elevated or irritable mood): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Aripiprazole and have Cholinergic syndrome?

Check whether Cholinergic syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Cholinergic syndrome and when was it recovered:

Expand to all the drugs that have ingredients of aripiprazole:

Alternative drugs to, pros and cons of Aripiprazole:

Common Aripiprazole side effects:

Browse all side effects of Aripiprazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Cholinergic syndrome treatments and more:

COVID vaccines that are related to Cholinergic syndrome:

All the drugs that are associated with Cholinergic syndrome:

All the conditions that are associated with Cholinergic syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on aripiprazole (the active ingredients of Aripiprazole) and Aripiprazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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