Aspirin and Dupuytren's contracture - a phase IV clinical study of FDA data


Dupuytren's contracture is found among people who take Aspirin, especially for people who are male, 60+ old, have been taking the drug for 6 - 12 months.

The phase IV clinical study analyzes which people take Aspirin and have Dupuytren's contracture. It is created by eHealthMe based on reports of 499,395 people who have side effects when taking Aspirin from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On Jun, 20, 2022

499,395 people reported to have side effects when taking Aspirin.
Among them, 53 people (0.01%) have Dupuytren's contracture.

What is Aspirin?

Aspirin has active ingredients of aspirin. It is often used in blood clots. eHealthMe is studying from 508,115 Aspirin users for its effectiveness, alternative drugs and more.

What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 434 drugs and 193 conditions by eHealthMe.

Number of Aspirin and Dupuytren's contracture reports submitted per year:

Could Aspirin cause Dupuytren's contracture?

Time on Aspirin when people have Dupuytren's contracture *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 100 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Dupuytren's contracture when taking Aspirin *:

  • female: 23.53 %
  • male: 76.47 %

Age of people who have Dupuytren's contracture when taking Aspirin *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 13.16 %
  • 60+: 86.84 %

Common drugs people take besides Aspirin *:

  1. Lisinopril: 13 people, 24.53%
  2. Zometa: 12 people, 22.64%
  3. Prednisone: 11 people, 20.75%
  4. Lasix: 10 people, 18.87%
  5. Colace: 9 people, 16.98%
  6. Lipitor: 9 people, 16.98%
  7. Zocor: 9 people, 16.98%
  8. Aredia: 8 people, 15.09%
  9. Alkeran: 8 people, 15.09%
  10. Cytoxan: 8 people, 15.09%

Common side effects people have besides Dupuytren's contracture *:

  1. Pain: 15 people, 28.30%
  2. Anaemia (lack of blood): 13 people, 24.53%
  3. Fall: 13 people, 24.53%
  4. Breathing Difficulty: 13 people, 24.53%
  5. Stress And Anxiety: 13 people, 24.53%
  6. Bone Disorder: 12 people, 22.64%
  7. Coronary Heart Disease (narrowing or blockage of the coronary arteries): 12 people, 22.64%
  8. Depression: 12 people, 22.64%
  9. Injury: 12 people, 22.64%
  10. Visual Impairment: 10 people, 18.87%

Common conditions people have *:

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 11.32%
  2. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 9.43%
  3. Joint Pain: 5 people, 9.43%
  4. Type 2 Diabetes: 4 people, 7.55%
  5. Malignant Melanoma (skin cancer rises from melancytes): 4 people, 7.55%
  6. Itching: 4 people, 7.55%
  7. High Blood Cholesterol: 3 people, 5.66%
  8. Bone Density Decreased: 3 people, 5.66%
  9. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 5.66%
  10. Chest Pain: 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

Do you take Aspirin and have Dupuytren's contracture?

Check whether Dupuytren's contracture is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of Aspirin:

Dupuytren's contracture treatments and more:

COVID vaccines that are related to Dupuytren's contracture:

How severe was Dupuytren's contracture and when was it recovered:

Expand to all the drugs that have ingredients of aspirin:

Common drugs associated with Dupuytren's contracture:

All the drugs that are associated with Dupuytren's contracture:

All the conditions that are associated with Dupuytren's contracture:

How the study uses the data?

The study uses data from the FDA. It is based on aspirin (the active ingredients of Aspirin) and Aspirin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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