Azelastine hydrochloride and Restless leg syndrome - a phase IV clinical study of FDA data


Restless leg syndrome is reported only by a few people who take Azelastine Hydrochloride.

The phase IV clinical study analyzes which people take Azelastine hydrochloride and have Restless leg syndrome. It is created by eHealthMe based on reports of 2,842 people who have side effects while taking Azelastine hydrochloride from the FDA, and is updated regularly.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Nov, 20, 2022

2,842 people reported to have side effects when taking Azelastine hydrochloride.
Among them, 4 people (0.14%) have Restless leg syndrome.

What is Azelastine hydrochloride?

Azelastine hydrochloride has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 2,934 Azelastine hydrochloride users for its effectiveness, alternative drugs and more.

What is Restless leg syndrome?

Restless leg syndrome (a powerful urge to move your legs) is found to be associated with 2,369 drugs and 1,763 conditions by eHealthMe.

Number of Azelastine hydrochloride and Restless leg syndrome reports submitted per year:

Could Azelastine hydrochloride cause Restless leg syndrome?

Gender of people who have Restless leg syndrome when taking Azelastine hydrochloride *:

  • female: 50 %
  • male: 50 %

Age of people who have Restless leg syndrome when taking Azelastine hydrochloride *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 50 %
  • 60+: 50 %

Common drugs people take besides Azelastine hydrochloride *:

  1. Xywav: 2 people, 50.00%
  2. Zofran: 1 person, 25.00%
  3. Loratadine: 1 person, 25.00%
  4. Aldactone: 1 person, 25.00%
  5. Amphetamine Sulfate: 1 person, 25.00%
  6. Aspirin: 1 person, 25.00%
  7. Buspar: 1 person, 25.00%
  8. Celexa: 1 person, 25.00%
  9. Chantix: 1 person, 25.00%
  10. Coreg: 1 person, 25.00%

Common side effects people have besides Restless leg syndrome *:

  1. Agitation (state of anxiety or nervous excitement): 2 people, 50.00%
  2. Nervousness: 2 people, 50.00%
  3. Weight Loss: 1 person, 25.00%
  4. Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 1 person, 25.00%
  5. Adjustment Disorder: 1 person, 25.00%
  6. Asthma: 1 person, 25.00%
  7. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 25.00%
  8. Balance Disorder: 1 person, 25.00%
  9. Bruxism (habitual grinding of the teeth, typically during sleep): 1 person, 25.00%
  10. Conjunctivitis Allergic (inflammation of the conjunctiva due to allergy): 1 person, 25.00%

Common conditions people have *:

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 50.00%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 50.00%
  3. Quit Smoking: 1 person, 25.00%
  4. Insomnia (sleeplessness): 1 person, 25.00%
  5. High Blood Cholesterol: 1 person, 25.00%
  6. Drowsiness: 1 person, 25.00%
  7. Depression: 1 person, 25.00%
  8. Chest Pain: 1 person, 25.00%
  9. Cardiac Failure Congestive: 1 person, 25.00%
  10. Cardiac Disorder: 1 person, 25.00%

* Approximation only. Some reports may have incomplete information.

Do you take Azelastine hydrochloride and have Restless leg syndrome?

Check whether Restless leg syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Restless leg syndrome and when was it recovered:

Expand to all the drugs that have ingredients of azelastine hydrochloride:

Alternative drugs to, pros and cons of Azelastine hydrochloride:

Common Azelastine hydrochloride side effects:

Browse all side effects of Azelastine hydrochloride:

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Restless leg syndrome treatments and more:

COVID vaccines that are related to Restless leg syndrome:

Common drugs associated with Restless leg syndrome:

All the drugs that are associated with Restless leg syndrome:

Common conditions associated with Restless leg syndrome:

All the conditions that are associated with Restless leg syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on azelastine hydrochloride (the active ingredients of Azelastine hydrochloride) and Azelastine hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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