Bactrim and Lupus-like syndrome - a phase IV clinical study of FDA data


Lupus-like syndrome is found among people who take Bactrim, especially for people who are female, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Bactrim and have Lupus-like syndrome. It is created by eHealthMe based on reports of 75,954 people who have side effects when taking Bactrim from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 02, 2023

75,954 people reported to have side effects when taking Bactrim.
Among them, 9 people (0.01%) have Lupus-like syndrome.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 78,470 Bactrim users for its effectiveness, alternative drugs and more.

What is Lupus-like syndrome?

Lupus-like syndrome (a disease symptom matches with lupus an immune disease) is found to be associated with 908 drugs and 547 conditions by eHealthMe.

Number of Bactrim and Lupus-like syndrome reports submitted per year:

Could Bactrim cause Lupus-like syndrome?

Time on Bactrim when people have Lupus-like syndrome *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Lupus-like syndrome when taking Bactrim *:

  • female: 87.5 %
  • male: 12.5 %

Age of people who have Lupus-like syndrome when taking Bactrim *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 20 %
  • 40-49: 20 %
  • 50-59: 0.0 %
  • 60+: 60 %

Common drugs people take besides Bactrim *:

  1. Celebrex: 2 people, 22.22%
  2. Cardizem: 2 people, 22.22%
  3. Doxycycline: 2 people, 22.22%
  4. Nizoral: 2 people, 22.22%
  5. Nystatin: 2 people, 22.22%
  6. Coumadin: 2 people, 22.22%
  7. Fosamax: 2 people, 22.22%
  8. Levaquin: 2 people, 22.22%
  9. Plaquenil: 2 people, 22.22%
  10. Prednisone: 2 people, 22.22%

Common side effects people have besides Lupus-like syndrome *:

  1. Diarrhea: 3 people, 33.33%
  2. Rashes (redness): 3 people, 33.33%
  3. Nausea And Vomiting: 3 people, 33.33%
  4. Hypersensitivity: 2 people, 22.22%
  5. Pneumocystis Carinii Infection: 2 people, 22.22%
  6. Aortic Valve Incompetence: 2 people, 22.22%
  7. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 2 people, 22.22%
  8. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 22.22%
  9. Chest Pain: 2 people, 22.22%
  10. Endocarditis (inflammation in heart muscle): 2 people, 22.22%

Common conditions people have *:

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 22.22%
  2. Respiratory Tract Infection: 1 person, 11.11%
  3. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 11.11%
  4. Antisynthetase Syndrome (chronic autoimmune disease of unknown cause): 1 person, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Bactrim and have Lupus-like syndrome?

Check whether Lupus-like syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Lupus-like syndrome and when was it recovered:

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Alternative drugs to, pros and cons of Bactrim:

Common Bactrim side effects:

Browse all side effects of Bactrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Lupus-like syndrome treatments and more:

COVID vaccines that are related to Lupus-like syndrome:

Common drugs associated with Lupus-like syndrome:

All the drugs that are associated with Lupus-like syndrome:

Common conditions associated with Lupus-like syndrome:

All the conditions that are associated with Lupus-like syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Bactrim) and Bactrim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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