Benadryl and Pacing threshold increased - a phase IV clinical study of FDA data


Pacing threshold increased is reported only by a few people who take Benadryl.

The phase IV clinical study analyzes which people take Benadryl and have Pacing threshold increased. It is created by eHealthMe based on reports of 85,073 people who have side effects while taking Benadryl from the FDA, and is updated regularly.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Mar, 26, 2023

85,073 people reported to have side effects when taking Benadryl.
Among them, 1 person (0.0%) has Pacing threshold increased.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 89,762 Benadryl users for its effectiveness, alternative drugs and more.

What is Pacing threshold increased?

Pacing threshold increased is found to be associated with 23 drugs and 8 conditions by eHealthMe.

Number of Benadryl and Pacing threshold increased reports submitted per year:

Could Benadryl cause Pacing threshold increased?

Gender of people who have Pacing threshold increased when taking Benadryl *:

  • female: 0.0 %
  • male: 100 %

Age of people who have Pacing threshold increased when taking Benadryl *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 100 %
  • 60+: 0.0 %

Common drugs people take besides Benadryl *:

  1. Sudafed 12 Hour: 1 person, 100.00%
  2. Klonopin: 1 person, 100.00%
  3. Flomax: 1 person, 100.00%

Common side effects people have besides Pacing threshold increased *:

  1. Urinary Incontinence (inability to control the flow of urine and involuntary urination): 1 person, 100.00%
  2. Skin Warm: 1 person, 100.00%
  3. Rashes (redness): 1 person, 100.00%
  4. Oedema Lower Limb (fluid collection in tissue of lower leg): 1 person, 100.00%
  5. Faecal Incontinence (a lack of control over passing stool): 1 person, 100.00%
  6. Delusional Disorder, Persecutory Type (a belief that they (or someone close to them) are being mistreated): 1 person, 100.00%
  7. Collapse (sudden functional breakdown): 1 person, 100.00%
  8. Blood Chloride Increased: 1 person, 100.00%
  9. Atherosclerosis (disorder of the arteries): 1 person, 100.00%

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and have Pacing threshold increased?

Check whether Pacing threshold increased is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Pacing threshold increased and when was it recovered:

Expand to all the drugs that have ingredients of diphenhydramine hydrochloride:

Alternative drugs to, pros and cons of Benadryl:

Common Benadryl side effects:

Browse all side effects of Benadryl:

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Pacing threshold increased treatments and more:

COVID vaccines that are related to Pacing threshold increased:

All the drugs that are associated with Pacing threshold increased:

All the conditions that are associated with Pacing threshold increased:

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Benadryl) and Benadryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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