Bicnu and Pleural effusion - a phase IV clinical study of FDA data


We study 1,092 people who have side effects when taking Bicnu. Pleural effusion is found, especially among people who are male, 50-59 old, have been taking the drug for < 1 month, also take Zevalin and have Diffuse large b-cell lymphoma stage iv.

The phase IV clinical study analyzes which people take Bicnu and have Pleural effusion. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

What are phase IV trials?

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 24, 2023

1,092 people reported to have side effects when taking Bicnu.
Among them, 17 people (1.56%) have Pleural effusion.

What is Bicnu?

Bicnu has active ingredients of carmustine. Currently, eHealthMe is studying from 1,094 Bicnu users.

What is Pleural effusion?

Pleural effusion (water on the lungs) is found to be associated with 3,429 drugs and 3,059 conditions by eHealthMe. Currently, we are studying 81,253 people who have Pleural effusion.

Number of Bicnu and Pleural effusion reports submitted per year:

Could Bicnu cause Pleural effusion?

Time on Bicnu when people have Pleural effusion *:

  • < 1 month: 75 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 25 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Pleural effusion when taking Bicnu *:

  • female: 13.33 %
  • male: 86.67 %

Age of people who have Pleural effusion when taking Bicnu *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 13.33 %
  • 40-49: 13.33 %
  • 50-59: 53.33 %
  • 60+: 20.0 %

Common drugs people take besides Bicnu *:

  1. Zevalin: 8 people, 47.06%
  2. Alkeran: 2 people, 11.76%
  3. Vancomycin: 1 person, 5.88%
  4. Valacyclovir Hydrochloride: 1 person, 5.88%
  5. Augmentin: 1 person, 5.88%
  6. Bactrim: 1 person, 5.88%
  7. Baraclude: 1 person, 5.88%
  8. Clonazepam: 1 person, 5.88%
  9. Cytarabine: 1 person, 5.88%
  10. Etoposide: 1 person, 5.88%

Common side effects people have besides Pleural effusion *:

  1. Venoocclusive Liver Disease (small veins in the liver are obstructed): 8 people, 47.06%
  2. Hepatic Failure (liver failure): 7 people, 41.18%
  3. Lung Disorder (lung disease): 6 people, 35.29%
  4. Ascites (accumulation of fluid in the abdominal cavity): 6 people, 35.29%
  5. Alanine Aminotransferase Increased: 3 people, 17.65%
  6. Sepsis (a severe blood infection that can lead to organ failure and death): 3 people, 17.65%
  7. Aspartate Aminotransferase Increased: 3 people, 17.65%
  8. Gamma-Glutamyltransferase Increased: 2 people, 11.76%
  9. Interstitial Lung Disease: 2 people, 11.76%
  10. Organising Pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue): 2 people, 11.76%

Common conditions people have *:

  1. Diffuse Large B-Cell Lymphoma Stage Iv (cancer of b cells, a type of white blood cell-stage iv): 7 people, 41.18%
  2. Lymphoma (cancer that begins in immune system cells): 2 people, 11.76%
  3. Pneumonia: 1 person, 5.88%
  4. Nonspecific Reaction (unspecified reaction): 1 person, 5.88%
  5. Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 5.88%
  6. Mantle Cell Lymphoma Stage Iii (cancer of lymphocytes, a type of white blood cell- stage iii): 1 person, 5.88%
  7. Hodgkin's Lymphoma (cancer originating from white blood cells): 1 person, 5.88%
  8. Diarrhea: 1 person, 5.88%
  9. Cytomegalovirus Infection: 1 person, 5.88%
  10. Burkitt Lymphoma (cancer of the lymphatic system): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Bicnu and have Pleural effusion?

Check whether Pleural effusion is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Pleural effusion and when was it recovered:

Expand to all the drugs that have ingredients of carmustine:

Alternative drugs to, pros and cons of Bicnu:

Browse all side effects of Bicnu:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Pleural effusion treatments and more:

Common drugs associated with Pleural effusion:

All the drugs that are associated with Pleural effusion:

Common conditions associated with Pleural effusion:

All the conditions that are associated with Pleural effusion:

How the study uses the data?

The study uses data from the FDA. It is based on carmustine (the active ingredients of Bicnu) and Bicnu (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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