Boniva and Respiratory acidosis - a phase IV clinical study of FDA data


Respiratory acidosis is found among people who take Boniva, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years.

The phase IV clinical study analyzes which people take Boniva and have Respiratory acidosis. It is created by eHealthMe based on reports of 26,532 people who have side effects when taking Boniva from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 03, 2022

26,532 people reported to have side effects when taking Boniva.
Among them, 84 people (0.32%) have Respiratory acidosis.

What is Boniva?

Boniva has active ingredients of ibandronate sodium. It is often used in osteoporosis. eHealthMe is studying from 26,914 Boniva users for its effectiveness, alternative drugs and more.

What is Respiratory acidosis?

Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease) is found to be associated with 3,064 drugs and 3,254 conditions by eHealthMe.

Number of Boniva and Respiratory acidosis reports submitted per year:

Could Boniva cause Respiratory acidosis?

Time on Boniva when people have Respiratory acidosis *:

  • < 1 month: 7.69 %
  • 1 - 6 months: 7.69 %
  • 6 - 12 months: 15.38 %
  • 1 - 2 years: 7.69 %
  • 2 - 5 years: 30.77 %
  • 5 - 10 years: 7.69 %
  • 10+ years: 23.08 %

Gender of people who have Respiratory acidosis when taking Boniva *:

  • female: 91.25 %
  • male: 8.75 %

Age of people who have Respiratory acidosis when taking Boniva *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 1.61 %
  • 30-39: 17.74 %
  • 40-49: 1.61 %
  • 50-59: 9.68 %
  • 60+: 69.35 %

Common drugs people take besides Boniva *:

  1. Nexium: 22 people, 26.19%
  2. Folic Acid: 21 people, 25.00%
  3. Spiriva: 18 people, 21.43%
  4. Humira: 18 people, 21.43%
  5. Ambien: 14 people, 16.67%
  6. Prednisone: 14 people, 16.67%
  7. Fosamax: 13 people, 15.48%
  8. Methotrexate: 12 people, 14.29%
  9. Aspirin: 12 people, 14.29%
  10. Lexapro: 11 people, 13.10%

Common side effects people have besides Respiratory acidosis *:

  1. Pneumonia: 29 people, 34.52%
  2. Weight Decreased: 18 people, 21.43%
  3. Hypotension (abnormally low blood pressure): 17 people, 20.24%
  4. Back Pain: 16 people, 19.05%
  5. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 15 people, 17.86%
  6. Diarrhea: 15 people, 17.86%
  7. Renal Failure Acute (rapid kidney dysfunction): 14 people, 16.67%
  8. Femur Fracture: 14 people, 16.67%
  9. Fall: 13 people, 15.48%
  10. High Blood Pressure: 12 people, 14.29%

Common conditions people have *:

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 18 people, 21.43%
  2. Depression: 11 people, 13.10%
  3. Tuberculosis (a bacterial infection by mycobacterium tuberculosis): 10 people, 11.90%
  4. Joint Pain: 10 people, 11.90%
  5. Arrhythmias (irregular heartbeat): 9 people, 10.71%
  6. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 8.33%
  7. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 3.57%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 3.57%
  9. Pulmonary Hypertension (increase in blood pressure in the lung artery): 3 people, 3.57%
  10. Hair Loss: 2 people, 2.38%

* Approximation only. Some reports may have incomplete information.

Do you take Boniva and have Respiratory acidosis?

Check whether Respiratory acidosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Respiratory acidosis and when was it recovered:

Expand to all the drugs that have ingredients of ibandronate sodium:

Alternative drugs to, pros and cons of Boniva:

Common Boniva side effects:

Browse all side effects of Boniva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Respiratory acidosis treatments and more:

COVID vaccines that are related to Respiratory acidosis:

Common drugs associated with Respiratory acidosis:

All the drugs that are associated with Respiratory acidosis:

Common conditions associated with Respiratory acidosis:

All the conditions that are associated with Respiratory acidosis:

How the study uses the data?

The study uses data from the FDA. It is based on ibandronate sodium (the active ingredients of Boniva) and Boniva (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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