Brimonidine tartrate and Hyponatremia - a phase IV clinical study of FDA data


Hyponatremia is found among people who take Brimonidine tartrate, especially for people who are male, 60+ old.

The phase IV clinical study analyzes which people take Brimonidine tartrate and have Hyponatremia. It is created by eHealthMe based on reports of 2,536 people who have side effects when taking Brimonidine tartrate from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 16, 2022

2,536 people reported to have side effects when taking Brimonidine tartrate.
Among them, 21 people (0.83%) have Hyponatremia.

What is Brimonidine tartrate?

Brimonidine tartrate has active ingredients of brimonidine tartrate. It is often used in glaucoma. eHealthMe is studying from 2,313 Brimonidine tartrate users for its effectiveness, alternative drugs and more.

What is Hyponatremia?

Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration) is found to be associated with 2,526 drugs and 1,351 conditions by eHealthMe.

Number of Brimonidine tartrate and Hyponatremia reports submitted per year:

Could Brimonidine tartrate cause Hyponatremia?

Gender of people who have Hyponatremia when taking Brimonidine tartrate *:

  • female: 45 %
  • male: 55 %

Age of people who have Hyponatremia when taking Brimonidine tartrate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 100 %

Common drugs people take besides Brimonidine tartrate *:

  1. Xalatan: 10 people, 47.62%
  2. Arixtra: 7 people, 33.33%
  3. Aspirin: 6 people, 28.57%
  4. Sertraline: 6 people, 28.57%
  5. Citalopram Hydrobromide: 5 people, 23.81%
  6. Cosopt: 5 people, 23.81%
  7. Nexium: 5 people, 23.81%
  8. Simvastatin: 5 people, 23.81%
  9. Lansoprazole: 4 people, 19.05%
  10. Senna: 4 people, 19.05%

Common side effects people have besides Hyponatremia *:

  1. Confusional State: 11 people, 52.38%
  2. Loss Of Consciousness: 8 people, 38.10%
  3. Headache (pain in head): 7 people, 33.33%
  4. Haematuria (presence of blood in urine): 7 people, 33.33%
  5. Weakness: 6 people, 28.57%
  6. Presyncope: 4 people, 19.05%
  7. Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood): 4 people, 19.05%
  8. Hyperglycemia (high blood sugar): 4 people, 19.05%
  9. Malaise (a feeling of general discomfort or uneasiness): 3 people, 14.29%
  10. Liver Function Test Abnormal: 3 people, 14.29%

Common conditions people have *:

  1. Stress And Anxiety: 4 people, 19.05%
  2. Depression: 3 people, 14.29%
  3. Anaplastic Astrocytoma (tumour of the glial (supportive) tissue of the brain): 3 people, 14.29%
  4. Nervous System Disorder (a general class of medical conditions affecting the nervous system): 2 people, 9.52%
  5. Pain: 2 people, 9.52%
  6. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 9.52%
  7. Panic Disorder: 1 person, 4.76%
  8. Folate Deficiency (lack of folic acid): 1 person, 4.76%
  9. Balance Disorder: 1 person, 4.76%
  10. Bipolar Disorder (mood disorder): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Brimonidine tartrate and have Hyponatremia?

Check whether Hyponatremia is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

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How severe was Hyponatremia and when was it recovered:

Expand to all the drugs that have ingredients of brimonidine tartrate:

Alternative drugs to, pros and cons of Brimonidine tartrate:

Common Brimonidine tartrate side effects:

Browse all side effects of Brimonidine tartrate:

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Hyponatremia treatments and more:

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Common drugs associated with Hyponatremia:

All the drugs that are associated with Hyponatremia:

Common conditions associated with Hyponatremia:

All the conditions that are associated with Hyponatremia:

How the study uses the data?

The study uses data from the FDA. It is based on brimonidine tartrate (the active ingredients of Brimonidine tartrate) and Brimonidine tartrate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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