Carbamazepine and Ototoxicity - a phase IV clinical study of FDA data

• Carbamazepine (39,553 reports)

• Abasia (inability to walk): 115 reports
• Abdominal discomfort: 159 reports
• Abdominal distension: 145 reports
• Abdominal pain: 385 reports
• Abdominal pain upper: 309 reports
• Abnormal behavior: 335 reports
• Abortion induced (medically referred abortion): 141 reports
• Abortion spontaneous (naturally occurring miscarriage): 254 reports
• Accidental overdose (therapeutic agent): 120 reports
• Acute kidney failure: 283 reports
• Aggression: 588 reports
• Agitation (state of anxiety or nervous excitement): 709 reports
• Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 389 reports
• Alanine aminotransferase increased: 479 reports
• Altered state of consciousness (altered state of mind): 203 reports
• Anaemia (lack of blood): 430 reports
• Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 139 reports
• Anger: 128 reports
• Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight): 142 reports
• Anticonvulsant drug level increased: 211 reports
• Apathy: 127 reports
• Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 422 reports
• Ards (acute respiratory distress syndrome) (sudden failure of the respiratory (breathing) system): 157 reports
• Arrhythmias (irregular heartbeat): 463 reports
• Aspartate aminotransferase increased: 398 reports
• Asthma: 219 reports
• Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 208 reports
• Autism spectrum disorder (developmental disabilities that can cause significant social, communication and behavioural challenges): 101 reports
• Back pain: 344 reports
• Balance disorder: 1,135 reports
• Bipolar disorder (mood disorder): 124 reports
• Birth control: 163 reports
• Blindness: 113 reports
• Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 239 reports
• Blood alkaline phosphatase increased: 196 reports
• Blood bilirubin increased: 104 reports
• Blood calcium decreased: 578 reports
• Blood creatine phosphokinase increased: 250 reports
• Blood creatinine increased: 208 reports
• Blood glucose increased: 187 reports
• Blood lactate dehydrogenase increased: 124 reports
• Blood sodium decreased: 162 reports
• Blood urea increased: 116 reports
• Bradycardia (abnormally slow heart action): 291 reports
• Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 104 reports
• Breathing difficulty: 725 reports
• Breathing - slowed or stopped: 195 reports
• Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 123 reports
• Burning sensation: 147 reports
• Cardiac arrest: 457 reports
• Cardiac disorder: 141 reports
• Cardiac failure: 194 reports
• Cardiac failure congestive: 102 reports
• Cardio-respiratory arrest (sudden dysfunction of heart and lungs): 283 reports
• Central nervous system lesion (an abnormality in tissue of brain or spinal cord): 114 reports
• Chest pain: 481 reports
• Chills (felling of cold): 229 reports
• Chronic kidney disease: 131 reports
• Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 158 reports
• Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving): 641 reports
• Completed suicide (act of taking one's own life): 987 reports
• Complex partial seizures (epileptic seizure): 143 reports
• Confusion: 329 reports
• Confusional state: 809 reports
• Conjunctivitis (pink eye): 113 reports
• Consciousness - decreased: 525 reports
• Constipation: 688 reports
• Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1,389 reports
• Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly): 186 reports
• Cough: 566 reports
• C-reactive protein increased: 201 reports
• Creatinine renal clearance decreased: 225 reports
• Crying: 155 reports
• Death: 557 reports
• Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 121 reports
• Dehydration (dryness resulting from the removal of water): 284 reports
• Delirium (wild excitement): 229 reports
• Delusion (a false belief or opinion): 179 reports
• Dementia (madness): 134 reports
• Depressed level of consciousness: 960 reports
• Depressed mood: 268 reports
• Depression: 736 reports
• Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 174 reports
• Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss): 146 reports
• Diabetes: 195 reports
• Diarrhea: 768 reports
• Diplopia (double vision): 366 reports
• Discomfort: 113 reports
• Disease progression: 137 reports
• Disease recurrence: 154 reports
• Disseminated intravascular coagulation (systemic activation of blood coagulation): 134 reports
• Disturbance in attention: 309 reports
• Dizziness: 1,657 reports
• Drowsiness: 1,222 reports
• Drug abuse and dependence: 457 reports
• Drug dependence: 183 reports
• Drug effect decreased: 156 reports
• Drug eruption (adverse drug reaction of the skin): 193 reports
• Drug exposure during pregnancy: 382 reports
• Drug hypersensitivity: 592 reports
• Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications): 169 reports
• Drug ineffective: 2,618 reports
• Drug intolerance (drug sensitivity): 194 reports
• Drug level decreased: 229 reports
• Drug level increased: 295 reports
• Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash): 358 reports
• Drug resistance (reduction in effectiveness of a drug): 281 reports
• Drug toxicity: 417 reports
• Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 242 reports
• Dry mouth: 148 reports
• Dyskinesia (abnormality or impairment of voluntary movement): 293 reports
• Dysmorphism (difference of body structure that is suggestive of a congenital disorder): 174 reports
• Electrocardiogram qt prolonged: 182 reports
• Emotional distress: 130 reports
• Encephalopathy (functioning of the brain is affected by some agent or condition): 234 reports
• Eosinophilia (eosinophil count in the peripheral blood exceeds): 283 reports
• Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1,166 reports
• Erythema multiforme (a type of hypersensitivity reaction): 988 reports
• Extrapyramidal disorder (involuntary muscle spasms in the face and neck): 129 reports
• Eye disorder: 115 reports
• Eye movements - uncontrollable: 218 reports
• Eye pain: 104 reports
• Face oedema (swelling of face): 173 reports
• Facial pain: 109 reports
• Fainting (loss of consciousness and postural tone): 458 reports
• Fall: 2,105 reports
• Fatigue (feeling of tiredness): 1,690 reports
• Fear: 116 reports
• Fever: 1,781 reports
• Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 792 reports
• Gait disturbance: 754 reports
• Gallstones (stone formation by bile component): 120 reports
• Gamma-glutamyltransferase increased: 375 reports
• Gastric ulcer (stomach ulcer): 118 reports
• Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 125 reports
• Gastrointestinal disorder (functional problems of gastrointestinal tract): 121 reports
• General physical health deterioration (weak health status): 247 reports
• Grand mal convulsion (a type of generalized seizure that affects the entire brain): 444 reports
• Haemoglobin decreased: 266 reports
• Haemorrhage (bleeding): 122 reports
• Hair loss: 241 reports
• Hallucination, auditory (perceiving sounds without auditory stimulus): 140 reports
• Hallucinations (sensations that appear real but are created by your mind): 221 reports
• Hallucination, visual (seeing things that aren't there): 129 reports
• Headache (pain in head): 1,112 reports
• Head injury: 415 reports
• Heart attack: 211 reports
• Heart palpitations (feelings or sensations that your heart is pounding or racing): 173 reports
• Heart rate increased: 224 reports
• Hemiparesis (weakness on one side of the body): 125 reports
• Hepatic enzyme increased: 220 reports
• Hepatic failure (liver failure): 207 reports
• Hepatitis (inflammation of the liver): 213 reports
• Hepatomegaly (abnormal enlargement of the liver): 178 reports
• Hepatotoxicity (chemical-driven liver damage): 117 reports
• Herpes zoster: 120 reports
• High blood cholesterol: 260 reports
• High blood pressure: 840 reports
• Hoarseness or changing voice: 105 reports
• Hyperammonaemia: 157 reports
• Hyperglycemia (high blood sugar): 123 reports
• Hyperhidrosis (abnormally increased sweating): 292 reports
• Hyperkalemia (damage to or disease of the kidney): 116 reports
• Hypersensitivity: 386 reports
• Hypoaesthesia (reduced sense of touch or sensation): 378 reports
• Hypoglycemia (low blood sugar): 159 reports
• Hypokalemia (low potassium): 182 reports
• Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 885 reports
• Hypospadias (an abnormal condition in males in which the urethra opens on the under surface of the penis): 101 reports
• Hypotension (abnormally low blood pressure): 1,038 reports
• Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 136 reports
• Hypotonia (low muscle tone): 141 reports
• Inappropriate antidiuretic hormone secretion: 177 reports
• Indigestion: 142 reports
• Infection: 291 reports
• Inflammation: 114 reports
• Influenza like illness: 176 reports
• Injection site pain: 131 reports
• Injury: 117 reports
• Insomnia (sleeplessness): 759 reports
• Intentional overdose: 342 reports
• Intentional self-injury: 134 reports
• International normalised ratio increased: 122 reports
• Interstitial lung disease: 121 reports
• Intestinal obstruction: 118 reports
• Irritability: 332 reports
• Itching: 646 reports
• Jaundice - yellow skin (a yellowish pigmentation of the skin): 113 reports
• Joint pain: 521 reports
• Joint swelling: 145 reports
• Lactic acidosis (low ph in body tissues): 113 reports
• Leukocytosis (increased white blood cells): 159 reports
• Leukopenia (less number of white blood cells in blood): 285 reports
• Liver disorder (liver diseases): 174 reports
• Loss of consciousness: 775 reports
• Low tissue oxygen: 127 reports
• Lung disorder (lung disease): 127 reports
• Lymph follicular hypertrophy (an increase in the size of the lymph node follicles): 314 reports
• Lymphopenia (an abnormally low level of lymphocytes in the blood): 108 reports
• Malaise (a feeling of general discomfort or uneasiness): 1,038 reports
• Mania (a state of abnormally elevated or irritable mood): 204 reports
• Maternal drugs affecting foetus (chemical affecting the baby before birth taken by mother): 238 reports
• Maternal exposure during pregnancy (use of substance during pregnancy): 395 reports
• Memory loss: 840 reports
• Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 225 reports
• Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 180 reports
• Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 160 reports
• Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 174 reports
• Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night): 106 reports
• Migraine (headache): 180 reports
• Mobility decreased (ability to move is reduced): 778 reports
• Mood swings (an extreme or rapid change in mood): 246 reports
• Mouth ulcers: 123 reports
• Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 133 reports
• Movement - uncontrolled or slow: 138 reports
• Movement - uncoordinated: 533 reports
• Multi-organ failure (multisystem organ failure): 179 reports
• Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 219 reports
• Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 323 reports
• Muscle aches (muscle pain): 231 reports
• Muscle spasms (muscle contraction): 346 reports
• Muscle twitching: 127 reports
• Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 202 reports
• Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 175 reports
• Nasopharyngitis (inflammation of the nasopharynx): 303 reports
• Nausea (feeling of having an urge to vomit): 1,259 reports
• Nausea and vomiting: 1,234 reports
• Neck pain: 130 reports
• Nervousness: 195 reports
• Nervous system disorder (a general class of medical conditions affecting the nervous system): 107 reports
• Neuralgia (pain in one or more nerves): 114 reports
• Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 232 reports
• Neuropathy peripheral (surface nerve damage): 151 reports
• Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system): 117 reports
• Nightmares (unpleasant dreams): 106 reports
• Nosebleed (bleeding from nose): 115 reports
• Oedema (fluid collection in tissue): 153 reports
• Oedema peripheral (superficial swelling): 318 reports
• Oropharyngeal pain: 133 reports
• Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 339 reports
• Osteoporosis (bones weak and more likely to break): 108 reports
• Overdose: 1,071 reports
• Oxygen saturation decreased: 112 reports
• Pain: 1,530 reports
• Pain in extremity: 503 reports
• Pancreatitis (inflammation of pancreas): 182 reports
• Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 182 reports
• Panic disorder: 140 reports
• Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 409 reports
• Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 121 reports
• Parkinson's disease: 107 reports
• Partial seizures (seizures which affect only a part of the brain at onset): 256 reports
• Peripheral swelling: 147 reports
• Petit mal epilepsy (absence seizure): 255 reports
• Pleural effusion (water on the lungs): 151 reports
• Pneumonia: 755 reports
• Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 219 reports
• Poisoning: 120 reports
• Premature baby: 170 reports
• Productive cough: 211 reports
• Psychomotor hyperactivity (feelings of extreme restlessness): 187 reports
• Psychotic disorder: 337 reports
• Pulmonary embolism (blockage of the main artery of the lung): 219 reports
• Pulmonary oedema (fluid accumulation in the lungs): 196 reports
• Rash erythematous (redness of the skin): 207 reports
• Rashes (redness): 1,524 reports
• Rash macular (small, flat red spots): 109 reports
• Rash maculo-papular (red area on the skin that is covered with small confluent bumps): 351 reports
• Rash pruritic (redness with itching): 130 reports
• Renal failure acute (rapid kidney dysfunction): 243 reports
• Renal impairment (severely reduced kidney function): 227 reports
• Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 342 reports
• Respiratory depression (respiration has a rate below 12 breaths): 101 reports
• Respiratory distress (difficulty in breathing): 128 reports
• Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 240 reports
• Road traffic accident: 121 reports
• Salivary hypersecretion (excess saliva secretion): 106 reports
• Sedation: 676 reports
• Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1,718 reports
• Sepsis (a severe blood infection that can lead to organ failure and death): 284 reports
• Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 176 reports
• Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 105 reports
• Skin blushing/flushing (a sudden reddening of the face, neck): 169 reports
• Skin discoloration: 133 reports
• Skin exfoliation (removal of the oldest dead skin cells): 221 reports
• Sleep disorder: 353 reports
• Speech disorder: 401 reports
• Speech impairment (adult) (inability to speak (adult)): 687 reports
• Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 633 reports
• Stomatitis (inflammation of mucous membrane of mouth): 133 reports
• Stress and anxiety: 808 reports
• Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 292 reports
• Suicidal ideation: 420 reports
• Suicide attempt: 527 reports
• Swallowing difficulty: 356 reports
• Swelling: 165 reports
• Swelling face: 155 reports
• The flu (the flu is caused by an influenza virus): 200 reports
• Therapeutic response decreased (less preventive response): 143 reports
• Thrombocytopenia (decrease of platelets in blood): 599 reports
• Thrombosis (formation of a blood clot inside a blood vessel): 103 reports
• Transaminases increased: 125 reports
• Tremor (trembling or shaking movements in one or more parts of your body): 754 reports
• Trigeminal neuralgia (a painful condition of the nerve responsible for most facial sensation): 217 reports
• Type 2 diabetes: 118 reports
• Unresponsive to stimuli: 191 reports
• Upper respiratory tract infection: 119 reports
• Urinary incontinence (inability to control the flow of urine and involuntary urination): 213 reports
• Urinary retention (the inability to completely or partially empty the bladder): 135 reports
• Urinary tract infection: 513 reports
• Urticaria (rash of round, red welts on the skin that itch intensely): 332 reports
• Vision blurred: 428 reports
• Visual acuity reduced (reduced clearness of vision): 125 reports
• Visual impairment: 266 reports
• Weakness: 1,229 reports
• Weight decreased: 655 reports
• Weight increased: 550 reports
• Wheezing (a high-pitched whistling sound made while you breath): 145 reports
• White blood cell count decreased: 290 reports
• White blood cell count increased: 155 reports
• Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 154 reports

• Ototoxicity (1,631 reports)

All the drugs that are associated with Ototoxicity:

• Ototoxicity (599 drugs)

All the conditions that are associated with Ototoxicity:

• Ototoxicity (337 conditions)

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