Carpine and Visual field defect - a phase IV clinical study of FDA data


We study 5,197 people who have side effects when taking Carpine. Visual field defect is found, especially among people who are female, 40-49 old, have been taking the drug for 2 - 5 years, also take Timolol maleate and have Intraocular pressure increased.

The phase IV clinical study analyzes which people take Carpine and have Visual field defect. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 26, 2023

5,197 people reported to have side effects when taking Carpine.
Among them, 17 people (0.33%) have Visual field defect.

What is Carpine?

Carpine has active ingredients of pilocarpine hydrochloride. Currently, eHealthMe is studying from 5,235 Carpine users.

What is Visual field defect?

Visual field defect is found to be associated with 1,445 drugs and 1,014 conditions by eHealthMe. Currently, we are studying 8,622 people who have Visual field defect.

Number of Carpine and Visual field defect reports submitted per year:

Could Carpine cause Visual field defect?

Time on Carpine when people have Visual field defect *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Visual field defect when taking Carpine *:

  • female: 66.67 %
  • male: 33.33 %

Age of people who have Visual field defect when taking Carpine *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 18.18 %
  • 30-39: 0.0 %
  • 40-49: 54.55 %
  • 50-59: 9.09 %
  • 60+: 18.18 %

Common drugs people take besides Carpine *:

  1. Timolol Maleate: 4 people, 23.53%
  2. Cipro: 3 people, 17.65%
  3. Latanoprost: 2 people, 11.76%
  4. Trusopt: 2 people, 11.76%
  5. Azopt: 2 people, 11.76%
  6. Methotrexate: 2 people, 11.76%
  7. Dorzolamide Hydrochloride: 2 people, 11.76%
  8. Cyclophosphamide: 1 person, 5.88%
  9. Lamotrigine: 1 person, 5.88%
  10. Hydrocortisone: 1 person, 5.88%

Common side effects people have besides Visual field defect *:

  1. Drug Ineffective: 9 people, 52.94%
  2. Intraocular Pressure Increased: 5 people, 29.41%
  3. Scotoma (an area of diminished vision within the visual field): 4 people, 23.53%
  4. Vision Blurred: 3 people, 17.65%
  5. Hyphaema (collection of blood inside the front part of the eye): 3 people, 17.65%
  6. Optic Neuritis Retrobulbar (a form of optic neuritis in which the optic nerve, which is at the back of the eye, becomes inflamed): 3 people, 17.65%
  7. Weight Increased: 2 people, 11.76%
  8. Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 2 people, 11.76%
  9. Crying: 2 people, 11.76%
  10. Depression: 2 people, 11.76%

Common conditions people have *:

  1. Intraocular Pressure Increased: 4 people, 23.53%
  2. Glaucoma (increased fluid pressure in the eye with vision loss): 3 people, 17.65%
  3. Anterior Chamber Disorder: 2 people, 11.76%
  4. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 5.88%
  5. Pupillary Disorder (disorder of the pupil of eyes): 1 person, 5.88%
  6. Pain: 1 person, 5.88%
  7. Osteoporosis (bones weak and more likely to break): 1 person, 5.88%
  8. Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 5.88%
  9. Eye Inflammation: 1 person, 5.88%
  10. Cycloplegia (paralysis of the ciliary muscle of the eye): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Carpine and have Visual field defect?

Check whether Visual field defect is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Carpine side effects by duration, gender and age:

Visual field defect treatments and more:

Common drugs associated with Visual field defect:

All the drugs that are associated with Visual field defect:

Common conditions associated with Visual field defect:

All the conditions that are associated with Visual field defect:

How the study uses the data?

The study uses data from the FDA. It is based on pilocarpine hydrochloride (the active ingredients of Carpine) and Carpine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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