Cefazolin and Ototoxicity - a phase IV clinical study of FDA data
Summary:
Ototoxicity is found among people who take Cefazolin, especially for people who are male, 60+ old, have been taking the drug for < 1 month.
The phase IV clinical study analyzes which people take Cefazolin and have Ototoxicity. It is created by eHealthMe based on reports of 12,902 people who have side effects when taking Cefazolin from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
12,902 people reported to have side effects when taking Cefazolin.
Among them, 6 people (0.05%) have Ototoxicity.
What is Cefazolin?
Cefazolin has active ingredients of cefazolin sodium. It is often used in infection. eHealthMe is studying from 11,815 Cefazolin users for its effectiveness, alternative drugs and more.
What is Ototoxicity?
Ototoxicity (damage to the ear) is found to be associated with 599 drugs and 337 conditions by eHealthMe.
Number of Cefazolin and Ototoxicity reports submitted per year:
Time on Cefazolin when people have Ototoxicity *:
- < 1 month: 100 %
- 1 - 6 months: 0.0 %
- 6 - 12 months: 0.0 %
- 1 - 2 years: 0.0 %
- 2 - 5 years: 0.0 %
- 5 - 10 years: 0.0 %
- 10+ years: 0.0 %
Gender of people who have Ototoxicity when taking Cefazolin *:
- female: 16.67 %
- male: 83.33 %
Age of people who have Ototoxicity when taking Cefazolin *:
- 0-1: 0.0 %
- 2-9: 33.33 %
- 10-19: 0.0 %
- 20-29: 0.0 %
- 30-39: 0.0 %
- 40-49: 16.67 %
- 50-59: 16.67 %
- 60+: 33.33 %
Common drugs people take besides Cefazolin *:
- Timentin: 2 people, 33.33%
- Ondansetron: 2 people, 33.33%
- Morphine: 2 people, 33.33%
- Codeine: 2 people, 33.33%
- Vancomycin: 1 person, 16.67%
- Paracetamol: 1 person, 16.67%
- Heparin: 1 person, 16.67%
- Gentamicin: 1 person, 16.67%
Common side effects people have besides Ototoxicity *:
- Neurosensory Hypoacusis (a type of hearing loss in which the root cause lies in the vestibulocochlear nerve): 2 people, 33.33%
- Dizziness: 2 people, 33.33%
- Vestibular Disorder (disorders of the body's balance (vestibular) system in the inner ear): 1 person, 16.67%
- Small Intestinal Obstruction (blockage in small intestine): 1 person, 16.67%
- Renal Failure Acute (rapid kidney dysfunction): 1 person, 16.67%
- Leukopenia (less number of white blood cells in blood): 1 person, 16.67%
- Hypoacusis (loss of hearing): 1 person, 16.67%
- Deafness Neurosensory: 1 person, 16.67%
Common conditions people have *:
- Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 2 people, 33.33%
- Medulloblastoma (a fast-growing, high-grade tumour that always begins in the cerebellum): 2 people, 33.33%
- Arthritis Infective (purulent invasion of a joint by an infectious agent which produces arthritis): 1 person, 16.67%
* Approximation only. Some reports may have incomplete information.
Do you take Cefazolin and have Ototoxicity?
Check whether Ototoxicity is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
How severe was Ototoxicity and when was it recovered:
Expand to all the drugs that have ingredients of cefazolin sodium:
Alternative drugs to, pros and cons of Cefazolin:
- Cefazolin (11,815 reports)
Common Cefazolin side effects:
- Abdominal discomfort: 195 reports
- Abdominal pain: 266 reports
- Acute kidney failure: 598 reports
- Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 212 reports
- Alanine aminotransferase increased: 227 reports
- Anaemia (lack of blood): 536 reports
- Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 740 reports
- Anhedonia (inability to experience pleasure from activities usually found enjoyable): 255 reports
- Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 111 reports
- Arrhythmias (irregular heartbeat): 311 reports
- Aspartate aminotransferase increased: 207 reports
- Atelectasis (partial or complete collapse of the lung): 126 reports
- Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 163 reports
- Back pain: 293 reports
- Blood creatinine increased: 200 reports
- Blood urea increased: 112 reports
- Bone disorder: 116 reports
- Bradycardia (abnormally slow heart action): 194 reports
- Breathing difficulty: 475 reports
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 116 reports
- Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 136 reports
- Cardiac arrest: 308 reports
- Cardiac failure: 102 reports
- Cardiac failure congestive: 118 reports
- Cardio-respiratory arrest (sudden dysfunction of heart and lungs): 126 reports
- Cellulitis (infection under the skin): 211 reports
- Chest pain: 292 reports
- Chills (felling of cold): 172 reports
- Chronic kidney disease: 140 reports
- Confusional state: 158 reports
- Constipation: 205 reports
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 104 reports
- Cough: 175 reports
- C-reactive protein increased: 118 reports
- Death: 308 reports
- Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 176 reports
- Dehydration (dryness resulting from the removal of water): 151 reports
- Depressed level of consciousness: 164 reports
- Depression: 251 reports
- Diarrhea: 440 reports
- Disseminated intravascular coagulation (systemic activation of blood coagulation): 164 reports
- Dizziness: 227 reports
- Drowsiness: 119 reports
- Drug hypersensitivity: 401 reports
- Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications): 127 reports
- Drug ineffective: 491 reports
- Emotional distress: 368 reports
- Erythema multiforme (a type of hypersensitivity reaction): 225 reports
- Fainting (loss of consciousness and postural tone): 125 reports
- Fall: 275 reports
- Fatigue (feeling of tiredness): 307 reports
- Fear: 291 reports
- Febrile neutropenia (fever with reduced white blood cells): 102 reports
- Fever: 829 reports
- Gait disturbance: 131 reports
- Gallstones (stone formation by bile component): 135 reports
- Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 109 reports
- Gastrointestinal haemorrhage (bleeding gastrointestinal tract): 106 reports
- General physical health deterioration (weak health status): 129 reports
- Haematocrit decreased: 125 reports
- Haematoma (collection of blood outside the blood vessels): 114 reports
- Haemoglobin decreased: 238 reports
- Haemorrhage (bleeding): 144 reports
- Headache (pain in head): 264 reports
- Heart attack: 115 reports
- Heart rate increased: 111 reports
- High blood pressure: 338 reports
- Hyperhidrosis (abnormally increased sweating): 101 reports
- Hyperkalemia (damage to or disease of the kidney): 152 reports
- Hypersensitivity: 151 reports
- Hypoaesthesia (reduced sense of touch or sensation): 145 reports
- Hypokalemia (low potassium): 161 reports
- Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 116 reports
- Hypotension (abnormally low blood pressure): 1,020 reports
- Infection: 334 reports
- Injury: 432 reports
- Insomnia (sleeplessness): 156 reports
- International normalised ratio increased: 101 reports
- Interstitial lung disease: 113 reports
- Intervertebral disc protrusion (spinal disc protrusion): 101 reports
- Itching: 284 reports
- Joint pain: 231 reports
- Leukopenia (less number of white blood cells in blood): 102 reports
- Loss of consciousness: 132 reports
- Low tissue oxygen: 142 reports
- Malaise (a feeling of general discomfort or uneasiness): 157 reports
- Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 121 reports
- Multi-organ failure (multisystem organ failure): 305 reports
- Muscle spasms (muscle contraction): 106 reports
- Nausea (feeling of having an urge to vomit): 577 reports
- Nausea and vomiting: 383 reports
- Neck pain: 108 reports
- Neuropathy peripheral (surface nerve damage): 116 reports
- Nosebleed (bleeding from nose): 103 reports
- Oedema (fluid collection in tissue): 138 reports
- Oedema peripheral (superficial swelling): 225 reports
- Osteoarthritis (a joint disease caused by cartilage loss in a joint): 166 reports
- Osteomyelitis (infection of bone): 130 reports
- Osteonecrosis of jaw (death of bone of jaw): 162 reports
- Oxygen saturation decreased: 163 reports
- Pain: 728 reports
- Pain in extremity: 203 reports
- Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 184 reports
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 127 reports
- Pleural effusion (water on the lungs): 256 reports
- Pneumonia: 377 reports
- Post procedural complication: 129 reports
- Pulmonary embolism (blockage of the main artery of the lung): 156 reports
- Pulmonary oedema (fluid accumulation in the lungs): 155 reports
- Rashes (redness): 951 reports
- Renal failure acute (rapid kidney dysfunction): 313 reports
- Renal impairment (severely reduced kidney function): 423 reports
- Renal injury (kidney injury): 308 reports
- Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 286 reports
- Respiratory distress (difficulty in breathing): 102 reports
- Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 116 reports
- Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints): 184 reports
- Sepsis (a severe blood infection that can lead to organ failure and death): 349 reports
- Septic shock (shock due to blood infection): 153 reports
- Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 130 reports
- Staphylococcal infection (an infection with staphylococcus bacteria): 157 reports
- Stress and anxiety: 592 reports
- Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 103 reports
- Swallowing difficulty: 155 reports
- Thrombocytopenia (decrease of platelets in blood): 514 reports
- Urinary tract infection: 221 reports
- Urticaria (rash of round, red welts on the skin that itch intensely): 326 reports
- Weakness: 317 reports
- Weight decreased: 128 reports
- White blood cell count decreased: 133 reports
- White blood cell count increased: 156 reports
Browse all side effects of Cefazolin:
a b c d e f g h i j k l m n o p q r s t u v w x y zOtotoxicity treatments and more:
- Ototoxicity (1,631 reports)
COVID vaccines that are related to Ototoxicity:
- Ototoxicity in Moderna COVID Vaccine
- Ototoxicity in Pfizer BioNTech Covid Vaccine
- Ototoxicity in Johnson and Johnson Covid Vaccine
Common drugs associated with Ototoxicity:
- Carboplatin: 234 reports
- Cisplatin: 258 reports
- Etoposide: 170 reports
- Gentamicin: 147 reports
All the drugs that are associated with Ototoxicity:
- Ototoxicity (599 drugs)
All the conditions that are associated with Ototoxicity:
- Ototoxicity (337 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on cefazolin sodium (the active ingredients of Cefazolin) and Cefazolin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
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