Chantix and Depression - a phase IV clinical study of FDA data
Summary:
Depression is found among people who take Chantix, especially for people who are female, 40-49 old, have been taking the drug for 1 - 6 months.
The phase IV clinical study analyzes which people take Chantix and have Depression. It is created by eHealthMe based on reports of 87,165 people who have side effects when taking Chantix from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
87,165 people reported to have side effects when taking Chantix.
Among them, 11,911 people (13.66%) have Depression.
What is Chantix?
Chantix has active ingredients of varenicline tartrate. It is often used in quit smoking. eHealthMe is studying from 89,310 Chantix users for its effectiveness, alternative drugs and more.
What is Depression?
Depression is found to be associated with 4,135 drugs and 4,000 conditions by eHealthMe.
Number of Chantix and Depression reports submitted per year:

Time on Chantix when people have Depression *:
Gender of people who have Depression when taking Chantix*:
Age of people who have Depression when taking Chantix *:
Common drugs people take besides Chantix *:
Common side effects people have besides Depression *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Chantix and have Depression?
Check whether Depression is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
Related studies
How severe was Depression and when was it recovered:
Expand to all the drugs that have ingredients of varenicline tartrate:
- Depression and drugs with ingredients of varenicline tartrate (12,171 reports)
Alternative drugs to, pros and cons of Chantix:
- Chantix (89,310 reports)
Common Chantix side effects:
- Depression: 11,911 reports
- Stress and anxiety: 9,959 reports
- Insomnia (sleeplessness): 6,406 reports
- Drug ineffective: 6,102 reports
- Suicidal ideation: 5,315 reports
- Nausea and vomiting: 4,794 reports
Browse all side effects of Chantix:
a b c d e f g h i j k l m n o p q r s t u v w x y zDepression treatments and more:
- Depression (598,502 reports)
COVID vaccines that are related to Depression:
- Depression in Moderna COVID Vaccine
- Depression in Pfizer BioNTech Covid Vaccine
- Depression in Johnson and Johnson Covid Vaccine
Common drugs associated with Depression:
- Chantix: 11,911 reports
- Prednisone: 9,984 reports
- Accutane: 9,826 reports
- Oxycontin: 9,692 reports
- Aspirin: 9,458 reports
- Zoloft: 8,834 reports
- Fosamax: 8,381 reports
- Vioxx: 7,964 reports
- Gabapentin: 7,920 reports
- Cymbalta: 7,851 reports
All the drugs that are associated with Depression:
- Depression (4,135 drugs)
Common conditions associated with Depression:
- Multiple sclerosis: 20,384 reports
- Pain: 12,961 reports
- High blood pressure: 10,315 reports
- Rheumatoid arthritis: 10,067 reports
- Stress and anxiety: 9,456 reports
All the conditions that are associated with Depression:
- Depression (4,000 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on varenicline tartrate (the active ingredients of Chantix) and Chantix (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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