Chantix and Large intestine perforation - a phase IV clinical study of FDA data


We study 87,500 people who have side effects when taking Chantix. Large intestine perforation is found, especially among people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take Hctz and have High blood cholesterol.

The phase IV clinical study analyzes which people take Chantix and have Large intestine perforation. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 26, 2023

87,500 people reported to have side effects when taking Chantix.
Among them, 12 people (0.01%) have Large intestine perforation.

What is Chantix?

Chantix has active ingredients of varenicline tartrate. It is used in quit smoking. Currently, eHealthMe is studying from 89,661 Chantix users.

What is Large intestine perforation?

Large intestine perforation (hole in large intestine) is found to be associated with 1,276 drugs and 750 conditions by eHealthMe. Currently, we are studying 7,869 people who have Large intestine perforation.

Number of Chantix and Large intestine perforation reports submitted per year:

Could Chantix cause Large intestine perforation?

Time on Chantix when people have Large intestine perforation *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 50 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Large intestine perforation when taking Chantix *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Large intestine perforation when taking Chantix *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 30 %
  • 60+: 70 %

Common drugs people take besides Chantix *:

  1. Lyrica: 3 people, 25.00%
  2. Coreg: 3 people, 25.00%
  3. Hctz: 3 people, 25.00%
  4. Dyazide: 2 people, 16.67%
  5. Neurontin: 2 people, 16.67%
  6. Famotidine: 2 people, 16.67%
  7. Ranexa: 2 people, 16.67%
  8. Norco: 2 people, 16.67%
  9. Flovent: 2 people, 16.67%
  10. Imfinzi: 1 person, 8.33%

Common side effects people have besides Large intestine perforation *:

  1. Nausea And Vomiting: 3 people, 25.00%
  2. Thrombocytopenia (decrease of platelets in blood): 3 people, 25.00%
  3. Nausea (feeling of having an urge to vomit): 3 people, 25.00%
  4. Bladder Cancer: 2 people, 16.67%
  5. Herpes Zoster: 2 people, 16.67%
  6. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 16.67%
  7. Malaise (a feeling of general discomfort or uneasiness): 2 people, 16.67%
  8. Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 16.67%
  9. Breathing Difficulty: 2 people, 16.67%
  10. Blood Glucose Increased: 2 people, 16.67%

Common conditions people have *:

  1. High Blood Cholesterol: 4 people, 33.33%
  2. Back Pain: 2 people, 16.67%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 16.67%
  4. Spinal Column Stenosis (narrowing of spinal column): 2 people, 16.67%
  5. Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 16.67%
  6. Stable Angina (a constant chest pain): 2 people, 16.67%
  7. Breakthrough Pain: 1 person, 8.33%
  8. Constipation: 1 person, 8.33%
  9. Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 8.33%
  10. Gastric Disorder (disease of stomach): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Chantix and have Large intestine perforation?

Check whether Large intestine perforation is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Chantix side effects by duration, gender and age:

Large intestine perforation treatments and more:

Common drugs associated with Large intestine perforation:

All the drugs that are associated with Large intestine perforation:

Common conditions associated with Large intestine perforation:

All the conditions that are associated with Large intestine perforation:

How the study uses the data?

The study uses data from the FDA. It is based on varenicline tartrate (the active ingredients of Chantix) and Chantix (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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