Cimetidine and Skin necrosis - a phase IV clinical study of FDA data


Skin necrosis is reported only by a few people who take Cimetidine.

The phase IV clinical study analyzes which people take Cimetidine and have Skin necrosis. It is created by eHealthMe based on reports of 9,352 people who have side effects while taking Cimetidine from the FDA, and is updated regularly.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 01, 2022

9,352 people reported to have side effects when taking Cimetidine.
Among them, 5 people (0.05%) have Skin necrosis.

What is Cimetidine?

Cimetidine has active ingredients of cimetidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 9,504 Cimetidine users for its effectiveness, alternative drugs and more.

What is Skin necrosis?

Skin necrosis (skin damage) is found to be associated with 1,189 drugs and 763 conditions by eHealthMe.

Number of Cimetidine and Skin necrosis reports submitted per year:

Could Cimetidine cause Skin necrosis?

Gender of people who have Skin necrosis when taking Cimetidine *:

  • female: 40 %
  • male: 60 %

Age of people who have Skin necrosis when taking Cimetidine *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 40 %
  • 60+: 60 %

Common drugs people take besides Cimetidine *:

  1. Warfarin Sodium: 1 person, 20.00%
  2. Lovastatin: 1 person, 20.00%
  3. Cefazolin: 1 person, 20.00%
  4. Depakote: 1 person, 20.00%
  5. Dexamethasone: 1 person, 20.00%
  6. Etodolac: 1 person, 20.00%
  7. Famotidine: 1 person, 20.00%
  8. Glipizide: 1 person, 20.00%
  9. Heparin: 1 person, 20.00%
  10. Ifosfamide: 1 person, 20.00%

Common side effects people have besides Skin necrosis *:

  1. Rashes (redness): 4 people, 80.00%
  2. Injection Site Necrosis (death of body tissue at injection site): 2 people, 40.00%
  3. Oedema Peripheral (superficial swelling): 2 people, 40.00%
  4. Injection Site Pruritus (severe itching at injection site): 2 people, 40.00%
  5. Subcutaneous Haematoma (collection of blood outside the blood vessels on the skin): 2 people, 40.00%
  6. Skin Ulcer: 2 people, 40.00%
  7. Hyperammonaemia: 1 person, 20.00%
  8. Hoarseness (changing voice): 1 person, 20.00%
  9. Foot Ulcer: 1 person, 20.00%
  10. Fever: 1 person, 20.00%

Common conditions people have *:

  1. Ovarian Cancer (cancer of ovary): 1 person, 20.00%
  2. Lung Adenocarcinoma (a form of non-small cell lung cancer): 1 person, 20.00%

* Approximation only. Some reports may have incomplete information.

Do you take Cimetidine and have Skin necrosis?

Check whether Skin necrosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Skin necrosis and when was it recovered:

Expand to all the drugs that have ingredients of cimetidine:

Alternative drugs to, pros and cons of Cimetidine:

Common Cimetidine side effects:

Browse all side effects of Cimetidine:

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Skin necrosis treatments and more:

COVID vaccines that are related to Skin necrosis:

Common drugs associated with Skin necrosis:

All the drugs that are associated with Skin necrosis:

Common conditions associated with Skin necrosis:

All the conditions that are associated with Skin necrosis:

How the study uses the data?

The study uses data from the FDA. It is based on cimetidine (the active ingredients of Cimetidine) and Cimetidine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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