Cladribine and Hypersplenism - a phase IV clinical study of FDA data


Hypersplenism is found among people who take Cladribine, especially for people who are female, 2-9 old.

The phase IV clinical study analyzes which people take Cladribine and have Hypersplenism. It is created by eHealthMe based on reports of 2,076 people who have side effects when taking Cladribine from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 03, 2022

2,076 people reported to have side effects when taking Cladribine.
Among them, 7 people (0.34%) have Hypersplenism.

What is Cladribine?

Cladribine has active ingredients of cladribine. eHealthMe is studying from 2,082 Cladribine users for its effectiveness, alternative drugs and more.

What is Hypersplenism?

Hypersplenism (enlarged spleen and a decrease in one or more types of blood cells) is found to be associated with 317 drugs and 155 conditions by eHealthMe.

Number of Cladribine and Hypersplenism reports submitted per year:

Could Cladribine cause Hypersplenism?

Gender of people who have Hypersplenism when taking Cladribine *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Hypersplenism when taking Cladribine *:

  • 0-1: 0.0 %
  • 2-9: 66.67 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 33.33 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Common drugs people take besides Cladribine *:

  1. Methotrexate: 3 people, 42.86%
  2. Ondansetron: 1 person, 14.29%
  3. Escitalopram: 1 person, 14.29%

Common side effects people have besides Hypersplenism *:

  1. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 5 people, 71.43%
  2. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 71.43%
  3. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 5 people, 71.43%
  4. Fever: 5 people, 71.43%
  5. Growth Hormone Deficiency: 5 people, 71.43%
  6. Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 4 people, 57.14%
  7. Hepatomegaly (abnormal enlargement of the liver): 4 people, 57.14%
  8. Cardiac Failure: 2 people, 28.57%
  9. High Blood Pressure: 2 people, 28.57%
  10. Nausea And Vomiting: 2 people, 28.57%

Common conditions people have *:

  1. Langerhans' Cell Histiocytosis: 5 people, 71.43%
  2. Systemic Mastocytosis (a condition caused by the accumulation of mast cells in more than one part of the body): 2 people, 28.57%
  3. Nausea And Vomiting: 1 person, 14.29%
  4. Nausea (feeling of having an urge to vomit): 1 person, 14.29%
  5. Liver Disorder (liver diseases): 1 person, 14.29%
  6. Disease Progression: 1 person, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Cladribine and have Hypersplenism?

Check whether Hypersplenism is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Hypersplenism and when was it recovered:

Expand to all the drugs that have ingredients of cladribine:

Alternative drugs to, pros and cons of Cladribine:

Common Cladribine side effects:

Browse all side effects of Cladribine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Hypersplenism treatments and more:

COVID vaccines that are related to Hypersplenism:

All the drugs that are associated with Hypersplenism:

All the conditions that are associated with Hypersplenism:

How the study uses the data?

The study uses data from the FDA. It is based on cladribine (the active ingredients of Cladribine) and Cladribine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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