Clopra and Hypothalamo-pituitary disorder - a phase IV clinical study of FDA data


Hypothalamo-pituitary disorder is found among people who take Clopra, especially for people who are male, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Clopra and have Hypothalamo-pituitary disorder. It is created by eHealthMe based on reports of 77,161 people who have side effects when taking Clopra from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 21, 2023

77,161 people reported to have side effects when taking Clopra.
Among them, 36 people (0.05%) have Hypothalamo-pituitary disorder.

What is Clopra?

Clopra has active ingredients of metoclopramide hydrochloride. eHealthMe is studying from 77,610 Clopra users for its effectiveness, alternative drugs and more.

What is Hypothalamo-pituitary disorder?

Hypothalamo-pituitary disorder (loss of function in an endocrine gland due to failure of the pituitary gland to secrete hormones which stimulate that gland's function) is found to be associated with 622 drugs and 316 conditions by eHealthMe.

Number of Clopra and Hypothalamo-pituitary disorder reports submitted per year:

Could Clopra cause Hypothalamo-pituitary disorder?

Time on Clopra when people have Hypothalamo-pituitary disorder *:

  • < 1 month: 50 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 50 %

Gender of people who have Hypothalamo-pituitary disorder when taking Clopra *:

  • female: 19.35 %
  • male: 80.65 %

Age of people who have Hypothalamo-pituitary disorder when taking Clopra *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 12.5 %
  • 30-39: 12.5 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 75.0 %

Common drugs people take besides Clopra *:

  1. Ondansetron: 25 people, 69.44%
  2. Pantoprazole: 22 people, 61.11%
  3. Bactrim: 12 people, 33.33%
  4. Metformin: 11 people, 30.56%
  5. Cyclophosphamide: 6 people, 16.67%
  6. Carboplatin: 6 people, 16.67%
  7. Dexamethasone: 6 people, 16.67%
  8. Haloperidol: 6 people, 16.67%
  9. Ciprofloxacin: 6 people, 16.67%
  10. Ceftriaxone: 6 people, 16.67%

Common side effects people have besides Hypothalamo-pituitary disorder *:

  1. Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 27 people, 75.00%
  2. Urinary Retention (the inability to completely or partially empty the bladder): 26 people, 72.22%
  3. Sinus Bradycardia (an unusually slow heartbeat due to heart disease): 25 people, 69.44%
  4. Delirium (wild excitement): 25 people, 69.44%
  5. Scrotal Pain: 25 people, 69.44%
  6. Hyperkalemia (damage to or disease of the kidney): 24 people, 66.67%
  7. Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 24 people, 66.67%
  8. Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 23 people, 63.89%
  9. Cytokine Release Syndrome (immediate complication occurring with the use of anti-t cell antibody infusions): 23 people, 63.89%
  10. Febrile Neutropenia (fever with reduced white blood cells): 23 people, 63.89%

Common conditions people have *:

  1. Bone Marrow Conditioning Regimen: 25 people, 69.44%
  2. Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system): 25 people, 69.44%
  3. Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 25 people, 69.44%
  4. Diabetes: 11 people, 30.56%
  5. Herpes Zoster: 7 people, 19.44%
  6. Cytokine Release Syndrome (immediate complication occurring with the use of anti-t cell antibody infusions): 3 people, 8.33%
  7. Renal Cell Carcinoma (a kidney cancer): 3 people, 8.33%
  8. Fatigue (feeling of tiredness): 3 people, 8.33%
  9. Fever: 3 people, 8.33%
  10. Hypotension (abnormally low blood pressure): 3 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Clopra and have Hypothalamo-pituitary disorder?

Check whether Hypothalamo-pituitary disorder is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Hypothalamo-pituitary disorder and when was it recovered:

Expand to all the drugs that have ingredients of metoclopramide hydrochloride:

Alternative drugs to, pros and cons of Clopra:

Common Clopra side effects:

Browse all side effects of Clopra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Hypothalamo-pituitary disorder treatments and more:

COVID vaccines that are related to Hypothalamo-pituitary disorder:

Common drugs associated with Hypothalamo-pituitary disorder:

All the drugs that are associated with Hypothalamo-pituitary disorder:

All the conditions that are associated with Hypothalamo-pituitary disorder:

How the study uses the data?

The study uses data from the FDA. It is based on metoclopramide hydrochloride (the active ingredients of Clopra) and Clopra (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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