Clopra and Ototoxicity - a phase IV clinical study of FDA data

• Clopra (65,737 reports)

• Abdominal discomfort: 389 reports
• Abdominal distension: 588 reports
• Abdominal pain: 1,668 reports
• Abdominal pain upper: 1,034 reports
• Abdominal tenderness: 102 reports
• Abnormal behavior: 112 reports
• Abscess (pus): 155 reports
• Activities of daily living impaired: 2,951 reports
• Acute kidney failure: 1,460 reports
• Acute myocardial infarction (acute heart attack): 196 reports
• Acute respiratory failure: 163 reports
• Adrenal insufficiency (condition in which the adrenal glands do not produce adequate amounts of steroids): 147 reports
• Aggression: 116 reports
• Agitation (state of anxiety or nervous excitement): 849 reports
• Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 1,626 reports
• Akathisia (a movement disorder characterized by a feeling of inner restlessness): 1,917 reports
• Alanine aminotransferase increased: 601 reports
• Anaemia (lack of blood): 2,044 reports
• Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 384 reports
• Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight): 299 reports
• Aplastic anemia: 117 reports
• Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 1,451 reports
• Ards (acute respiratory distress syndrome) (sudden failure of the respiratory (breathing) system): 153 reports
• Arrhythmias (irregular heartbeat): 858 reports
• Arthropathy: 153 reports
• Ascites (accumulation of fluid in the abdominal cavity): 375 reports
• Aseptic necrosis (the death of bone tissue due to a lack of blood supply): 156 reports
• Aspartate aminotransferase increased: 480 reports
• Asthma: 239 reports
• Atelectasis (partial or complete collapse of the lung): 346 reports
• Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 761 reports
• Back pain: 1,288 reports
• Bacteraemia (presence of bacteria in the blood): 136 reports
• Balance disorder: 317 reports
• Bleeding disorders: 109 reports
• Bleeding into the skin: 119 reports
• Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 343 reports
• Blood bilirubin increased: 383 reports
• Blood creatine phosphokinase increased: 149 reports
• Blood creatinine increased: 621 reports
• Blood glucose increased: 464 reports
• Blood sodium decreased: 237 reports
• Blood urea increased: 282 reports
• Body temperature increased: 169 reports
• Bradycardia (abnormally slow heart action): 373 reports
• Breathing difficulty: 2,642 reports
• Breathing - slowed or stopped: 132 reports
• Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 414 reports
• Cardiac arrest: 706 reports
• Cardiac failure: 451 reports
• Cardiac failure congestive: 486 reports
• Cardiac murmur (an heart sound in valve abnormality): 125 reports
• Cardiogenic shock (inadequate circulation of blood): 108 reports
• Cataract (clouding of the lens inside the eye): 205 reports
• Cellulitis (infection under the skin): 407 reports
• Cerebral haemorrhage (bleeding within the brain): 169 reports
• Cerebral infarction (less blood supply to brain resulting tissue damage): 142 reports
• Chest pain: 1,326 reports
• Chills (felling of cold): 532 reports
• Chronic kidney disease: 1,106 reports
• Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 346 reports
• Circulatory collapse: 178 reports
• Colonic polyp (extra part of colon tissue grow in intestine): 103 reports
• Completed suicide (act of taking one's own life): 207 reports
• Confusion: 362 reports
• Confusional state: 1,132 reports
• Conjunctivitis (pink eye): 122 reports
• Consciousness - decreased: 260 reports
• Constipation: 1,574 reports
• Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 416 reports
• Coronary heart disease (narrowing or blockage of the coronary arteries): 234 reports
• Cough: 989 reports
• Coughing up blood: 210 reports
• Crohn's disease (condition that causes inflammation of the gastrointestinal tract): 126 reports
• Cuts and puncture wounds: 114 reports
• Death: 1,765 reports
• Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 574 reports
• Dehydration (dryness resulting from the removal of water): 1,626 reports
• Delirium (wild excitement): 333 reports
• Depressed level of consciousness: 334 reports
• Depression: 1,461 reports
• Diabetes: 327 reports
• Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies): 132 reports
• Diarrhea: 3,221 reports
• Discomfort: 170 reports
• Disease progression: 489 reports
• Dizziness: 1,810 reports
• Drowsiness: 798 reports
• Drug abuse and dependence: 212 reports
• Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications): 122 reports
• Drug ineffective: 1,200 reports
• Drug toxicity: 179 reports
• Dry eyes (lack of adequate tears): 101 reports
• Dry mouth: 383 reports
• Dry skin: 209 reports
• Dyskinesia (abnormality or impairment of voluntary movement): 3,083 reports
• Dyspnea exertional: 260 reports
• Ear pain: 161 reports
• Eating disorder: 164 reports
• Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 151 reports
• Emotional disorder: 1,350 reports
• Emotional distress: 2,105 reports
• Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 116 reports
• Erythema multiforme (a type of hypersensitivity reaction): 673 reports
• Essential tremor: 139 reports
• Excessive eye blinking (excessive blinking is dry eyes): 305 reports
• Extrapyramidal disorder (involuntary muscle spasms in the face and neck): 14,447 reports
• Fainting (loss of consciousness and postural tone): 621 reports
• Fall: 1,379 reports
• Family stress: 1,981 reports
• Fatigue (feeling of tiredness): 3,004 reports
• Febrile neutropenia (fever with reduced white blood cells): 1,581 reports
• Femur fracture: 177 reports
• Fever: 2,888 reports
• Fibromyalgia (a long-term condition which causes pain all over the body): 146 reports
• Fluid retention (an abnormal accumulation of fluid in the blood): 125 reports
• Gait disturbance: 590 reports
• Gallbladder disorder: 145 reports
• Gallstones (stone formation by bile component): 421 reports
• Gamma-glutamyltransferase increased: 243 reports
• Gastric ulcer (stomach ulcer): 381 reports
• Gastritis (inflammation of stomach): 446 reports
• Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 720 reports
• Gastrointestinal disorder (functional problems of gastrointestinal tract): 427 reports
• Gastrointestinal haemorrhage (bleeding gastrointestinal tract): 425 reports
• General physical health deterioration (weak health status): 973 reports
• Gingival pain (gum pain): 101 reports
• Haematocrit decreased: 256 reports
• Haematoma (collection of blood outside the blood vessels): 134 reports
• Haematuria (presence of blood in urine): 263 reports
• Haemoglobin decreased: 943 reports
• Haemorrhage (bleeding): 243 reports
• Haemorrhoids (a swollen vein or group of veins in the region of the anus): 268 reports
• Hair loss: 588 reports
• Hallucinations (sensations that appear real but are created by your mind): 282 reports
• Headache (pain in head): 1,770 reports
• Head injury: 503 reports
• Heart attack: 537 reports
• Heart palpitations (feelings or sensations that your heart is pounding or racing): 407 reports
• Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 130 reports
• Hepatic failure (liver failure): 390 reports
• Hepatic steatosis (fatty liver disease): 164 reports
• Herpes zoster: 196 reports
• Hiatal hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 222 reports
• Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough): 122 reports
• High blood cholesterol: 283 reports
• High blood pressure: 1,419 reports
• Hoarseness or changing voice: 225 reports
• Hot flush (sudden feelings of heat): 169 reports
• Hyperglycemia (high blood sugar): 257 reports
• Hyperhidrosis (abnormally increased sweating): 583 reports
• Hyperkalemia (damage to or disease of the kidney): 503 reports
• Hyperlipidaemia (presence of excess lipids in the blood): 205 reports
• Hypersensitivity: 490 reports
• Hyperthyroidism (over activity of the thyroid gland): 114 reports
• Hypoaesthesia (reduced sense of touch or sensation): 583 reports
• Hypocalcaemia (levels of calcium in blood serum are abnormally low): 230 reports
• Hypoglycemia (low blood sugar): 314 reports
• Hypokalemia (low potassium): 835 reports
• Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 818 reports
• Hypotension (abnormally low blood pressure): 1,705 reports
• Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 219 reports
• Idiopathic pulmonary fibrosis (chronic lung disease): 122 reports
• Impaired healing: 200 reports
• Indigestion: 500 reports
• Infection: 696 reports
• Inflammation: 236 reports
• Injury: 1,364 reports
• Insomnia (sleeplessness): 848 reports
• International normalised ratio increased: 184 reports
• Interstitial nephritis (inflammation of the kidney): 194 reports
• Intervertebral disc protrusion (spinal disc protrusion): 235 reports
• Intestinal obstruction: 409 reports
• Irritability: 133 reports
• Irritable bowel syndrome: 105 reports
• Itching: 872 reports
• Jaundice - yellow skin (a yellowish pigmentation of the skin): 235 reports
• Joint pain: 1,072 reports
• Joint swelling: 233 reports
• Kidney stones: 176 reports
• Lacrimation increased: 231 reports
• Left ventricular dysfunction: 170 reports
• Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart): 104 reports
• Loss of consciousness: 630 reports
• Lower respiratory tract infection: 467 reports
• Low tissue oxygen: 298 reports
• Lung infection: 221 reports
• Lymph follicular hypertrophy (an increase in the size of the lymph node follicles): 198 reports
• Malaise (a feeling of general discomfort or uneasiness): 1,371 reports
• Malignant neoplasm progression (cancer tumour came back): 660 reports
• Melaena (the passage of black, tarry stools): 139 reports
• Memory loss: 601 reports
• Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 1,185 reports
• Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 237 reports
• Migraine (headache): 329 reports
• Mood swings (an extreme or rapid change in mood): 110 reports
• Mouth ulcers: 322 reports
• Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 3,154 reports
• Movement - uncontrolled or slow: 8,675 reports
• Movement - uncoordinated: 166 reports
• Movement - unpredictable or jerky: 238 reports
• Multi-organ failure (multisystem organ failure): 338 reports
• Muscle aches (muscle pain): 445 reports
• Muscle rigidity (muscle stiffness): 117 reports
• Muscle spasms (muscle contraction): 628 reports
• Muscle twitching: 211 reports
• Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 332 reports
• Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 108 reports
• Nasopharyngitis (inflammation of the nasopharynx): 331 reports
• Nausea (feeling of having an urge to vomit): 4,878 reports
• Nausea and vomiting: 3,874 reports
• Neck pain: 313 reports
• Nervousness: 144 reports
• Nervous system disorder (a general class of medical conditions affecting the nervous system): 7,523 reports
• Neuralgia (pain in one or more nerves): 130 reports
• Neuropathy peripheral (surface nerve damage): 1,014 reports
• Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection): 416 reports
• Night sweats (sweating in night): 171 reports
• Nosebleed (bleeding from nose): 406 reports
• Oedema peripheral (superficial swelling): 877 reports
• Oesophagitis (inflammation of oesophagus): 244 reports
• Oropharyngeal pain: 353 reports
• Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 142 reports
• Osteoarthritis (a joint disease caused by cartilage loss in a joint): 371 reports
• Osteomyelitis (infection of bone): 236 reports
• Osteonecrosis of jaw (death of bone of jaw): 336 reports
• Osteopenia (a condition where bone mineral density is lower than normal): 200 reports
• Osteoporosis (bones weak and more likely to break): 299 reports
• Overdose: 557 reports
• Oxygen saturation decreased: 353 reports
• Pain: 5,359 reports
• Pain in extremity: 1,014 reports
• Pain in jaw: 330 reports
• Paleness (unusual lightness of skin colour): 160 reports
• Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 544 reports
• Panic disorder: 152 reports
• Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 625 reports
• Parkinson's disease: 1,069 reports
• Paroxysmal supraventricular tachycardia: 110 reports
• Pathological fracture (broken bone caused by disease): 125 reports
• Pleural effusion (water on the lungs): 815 reports
• Pneumonia: 2,223 reports
• Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 140 reports
• Protein - urine: 106 reports
• Pulmonary embolism (blockage of the main artery of the lung): 844 reports
• Quality of life decreased: 2,133 reports
• Rashes (redness): 1,770 reports
• Renal disorder (kidney disease): 141 reports
• Renal failure acute (rapid kidney dysfunction): 856 reports
• Renal failure chronic (long lasting kidney dysfunction): 188 reports
• Renal impairment (severely reduced kidney function): 568 reports
• Renal tubular necrosis (death of kidney tubules): 137 reports
• Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 688 reports
• Restless leg syndrome (a powerful urge to move your legs): 842 reports
• Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints): 176 reports
• Scar: 132 reports
• Sedation: 135 reports
• Seizures (abnormal excessive or synchronous neuronal activity in the brain): 335 reports
• Sepsis (a severe blood infection that can lead to organ failure and death): 1,229 reports
• Septic shock (shock due to blood infection): 473 reports
• Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 421 reports
• Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 133 reports
• Sinus bradycardia (an unusually slow heartbeat due to heart disease): 111 reports
• Sinusitis (inflammation of sinus): 388 reports
• Skin discoloration - bluish (bluish colour of skin): 116 reports
• Skin ulcer: 126 reports
• Sleep apnea syndrome: 195 reports
• Small intestinal obstruction (blockage in small intestine): 166 reports
• Speech disorder: 334 reports
• Speech impairment (adult) (inability to speak (adult)): 500 reports
• Spinal osteoarthritis (joint cartilage loss in spine): 314 reports
• Stable angina (a constant chest pain): 159 reports
• Staphylococcal infection (an infection with staphylococcus bacteria): 274 reports
• Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria): 113 reports
• Stomatitis (inflammation of mucous membrane of mouth): 363 reports
• Stress and anxiety: 4,017 reports
• Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 445 reports
• Suicidal ideation: 617 reports
• Suicide attempt: 132 reports
• Surgery: 121 reports
• Swallowing difficulty: 735 reports
• Swelling: 275 reports
• Swelling face: 263 reports
• Swollen tongue (swelling of tongue): 169 reports
• Tachypnea: 151 reports
• Tardive dyskinesia (a disorder that involves involuntary movements): 17,542 reports
• Taste - impaired: 231 reports
• The flu (the flu is caused by an influenza virus): 233 reports
• Therapeutic agent toxicity (poisoning by ability to cure substance): 110 reports
• Thrombocytopenia (decrease of platelets in blood): 1,810 reports
• Thrombosis (formation of a blood clot inside a blood vessel): 231 reports
• Tinnitus (a ringing in the ears): 172 reports
• Tongue disorder (disease of tongue): 107 reports
• Tooth abscess (pus formation in tooth): 205 reports
• Toothaches (tooth pain): 156 reports
• Tooth extraction: 150 reports
• Tremor (trembling or shaking movements in one or more parts of your body): 2,630 reports
• Tricuspid valve incompetence (inefficient heart valve): 131 reports
• Trismus (reduced opening of the jaws): 113 reports
• Tumor: 134 reports
• Type 2 diabetes: 170 reports
• Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding): 121 reports
• Upper respiratory tract infection: 304 reports
• Urinary incontinence (inability to control the flow of urine and involuntary urination): 235 reports
• Urinary retention (the inability to completely or partially empty the bladder): 289 reports
• Urinary tract infection: 1,137 reports
• Urination - painful: 251 reports
• Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 153 reports
• Vision blurred: 351 reports
• Weakness: 2,699 reports
• Weight decreased: 1,588 reports
• Weight loss: 161 reports
• Wheezing (a high-pitched whistling sound made while you breath): 202 reports
• White blood cell count decreased: 539 reports

• Ototoxicity (1,631 reports)

All the drugs that are associated with Ototoxicity:

• Ototoxicity (599 drugs)

All the conditions that are associated with Ototoxicity:

• Ototoxicity (337 conditions)

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