Clozaril and Affect lability - a phase IV clinical study of FDA data

Summary:

Affect lability is found among people who take Clozaril, especially for people who are female, 20-29 old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Clozaril and have Affect lability. It is created by eHealthMe based on reports of 57,017 people who have side effects when taking Clozaril from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.



On Aug, 17, 2022

57,017 people reported to have side effects when taking Clozaril.
Among them, 22 people (0.04%) have Affect lability.


What is Clozaril?

Clozaril has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 53,603 Clozaril users for its effectiveness, alternative drugs and more.

What is Affect lability?

Affect lability (emotional incontinence) is found to be associated with 1,167 drugs and 734 conditions by eHealthMe.

Number of Clozaril and Affect lability reports submitted per year:

Could Clozaril cause Affect lability?

Time on Clozaril when people have Affect lability *:

  • < 1 month: 50.0 %
  • 1 - 6 months: 8.33 %
  • 6 - 12 months: 16.67 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 8.33 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 16.67 %

Gender of people who have Affect lability when taking Clozaril *:

  • female: 60 %
  • male: 40 %

Age of people who have Affect lability when taking Clozaril *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 18.75 %
  • 20-29: 37.5 %
  • 30-39: 12.5 %
  • 40-49: 25.0 %
  • 50-59: 0.0 %
  • 60+: 6.25 %

Common drugs people take besides Clozaril *:

  1. Aripiprazole: 7 people, 31.82%
  2. Lithium Carbonate: 5 people, 22.73%
  3. Lamictal: 4 people, 18.18%
  4. Haloperidol: 3 people, 13.64%
  5. Albuterol: 3 people, 13.64%
  6. Valproate Sodium: 3 people, 13.64%
  7. Moviprep: 3 people, 13.64%
  8. Olanzapine: 3 people, 13.64%
  9. Fluphenazine: 2 people, 9.09%
  10. Imiquimod: 2 people, 9.09%

Common side effects people have besides Affect lability *:

  1. Drowsiness: 7 people, 31.82%
  2. Psychotic Disorder: 7 people, 31.82%
  3. Nausea (feeling of having an urge to vomit): 7 people, 31.82%
  4. Delusion (a false belief or opinion): 7 people, 31.82%
  5. Thinking Abnormal: 5 people, 22.73%
  6. Nausea And Vomiting: 5 people, 22.73%
  7. Salivary Hypersecretion (excess saliva secretion): 5 people, 22.73%
  8. Sedation: 5 people, 22.73%
  9. Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 5 people, 22.73%
  10. White Blood Cell Count Increased: 5 people, 22.73%

Common conditions people have *:

  1. Affective Disorder (mental disorder): 6 people, 27.27%
  2. Constipation: 6 people, 27.27%
  3. Anogenital Warts: 3 people, 13.64%
  4. Tremor (trembling or shaking movements in one or more parts of your body): 3 people, 13.64%
  5. Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 3 people, 13.64%
  6. Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 13.64%
  7. Mania (a state of abnormally elevated or irritable mood): 2 people, 9.09%
  8. Depression: 2 people, 9.09%
  9. Insomnia (sleeplessness): 2 people, 9.09%
  10. White Blood Cell Count Increased: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Clozaril and have Affect lability?

Check whether Affect lability is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



Related publications that referenced our studies

Related studies

How severe was Affect lability and when was it recovered:

Expand to all the drugs that have ingredients of clozapine:

Alternative drugs to, pros and cons of Clozaril:

Common Clozaril side effects:

Browse all side effects of Clozaril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Affect lability treatments and more:

COVID vaccines that are related to Affect lability:

Common drugs associated with Affect lability:

All the drugs that are associated with Affect lability:

Common conditions associated with Affect lability:

All the conditions that are associated with Affect lability:

How the study uses the data?

The study uses data from the FDA. It is based on clozapine (the active ingredients of Clozaril) and Clozaril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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