Concerta and Limb discomfort - a phase IV clinical study of FDA data


Limb discomfort is found among people who take Concerta, especially for people who are female, 40-49 old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Concerta and have Limb discomfort. It is created by eHealthMe based on reports of 18,289 people who have side effects when taking Concerta from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Dec, 03, 2022

18,289 people reported to have side effects when taking Concerta.
Among them, 16 people (0.09%) have Limb discomfort.

What is Concerta?

Concerta has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 22,034 Concerta users for its effectiveness, alternative drugs and more.

What is Limb discomfort?

Limb discomfort (discomfort in leg) is found to be associated with 1,596 drugs and 987 conditions by eHealthMe.

Number of Concerta and Limb discomfort reports submitted per year:

Could Concerta cause Limb discomfort?

Time on Concerta when people have Limb discomfort *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Limb discomfort when taking Concerta *:

  • female: 76.92 %
  • male: 23.08 %

Age of people who have Limb discomfort when taking Concerta *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 14.29 %
  • 20-29: 28.57 %
  • 30-39: 14.29 %
  • 40-49: 42.86 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Common drugs people take besides Concerta *:

  1. Wellbutrin: 5 people, 31.25%
  2. Synthroid: 5 people, 31.25%
  3. Tylenol: 3 people, 18.75%
  4. Zyrtec: 2 people, 12.50%
  5. Ritalin: 2 people, 12.50%
  6. Lamictal: 2 people, 12.50%
  7. Lexapro: 2 people, 12.50%
  8. Elavil: 2 people, 12.50%
  9. Mirena: 2 people, 12.50%
  10. Nuvigil: 2 people, 12.50%

Common side effects people have besides Limb discomfort *:

  1. Stress And Anxiety: 7 people, 43.75%
  2. Fatigue (feeling of tiredness): 6 people, 37.50%
  3. Dizziness: 5 people, 31.25%
  4. Mood Swings (an extreme or rapid change in mood): 5 people, 31.25%
  5. Nausea (feeling of having an urge to vomit): 5 people, 31.25%
  6. Irritability: 4 people, 25.00%
  7. Breathing Difficulty: 4 people, 25.00%
  8. Hypoaesthesia (reduced sense of touch or sensation): 4 people, 25.00%
  9. Muscle Aches (muscle pain): 4 people, 25.00%
  10. Abdominal Pain: 4 people, 25.00%

Common conditions people have *:

  1. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 25.00%
  2. Immunodeficiency Common Variable: 2 people, 12.50%
  3. Cough: 2 people, 12.50%
  4. Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 2 people, 12.50%
  5. Wheezing (a high-pitched whistling sound made while you breath): 1 person, 6.25%
  6. Stress And Anxiety: 1 person, 6.25%
  7. Multiple Myeloma (cancer of the plasma cells): 1 person, 6.25%
  8. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 6.25%
  9. Birth Control: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Concerta and have Limb discomfort?

Check whether Limb discomfort is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

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How severe was Limb discomfort and when was it recovered:

Expand to all the drugs that have ingredients of methylphenidate hydrochloride:

Alternative drugs to, pros and cons of Concerta:

Common Concerta side effects:

Browse all side effects of Concerta:

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Limb discomfort treatments and more:

COVID vaccines that are related to Limb discomfort:

Common drugs associated with Limb discomfort:

All the drugs that are associated with Limb discomfort:

Common conditions associated with Limb discomfort:

All the conditions that are associated with Limb discomfort:

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate hydrochloride (the active ingredients of Concerta) and Concerta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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