Coreg and Drug level increased - a phase IV clinical study of FDA data


We study 47,373 people who have side effects when taking Coreg. Drug level increased is found, especially among people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take Synthroid and have High blood cholesterol.

The phase IV clinical study analyzes which people take Coreg and have Drug level increased. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 26, 2023

47,373 people reported to have side effects when taking Coreg.
Among them, 16 people (0.03%) have Drug level increased.

What is Coreg?

Coreg has active ingredients of carvedilol. It is used in high blood pressure. Currently, eHealthMe is studying from 48,772 Coreg users.

What is Drug level increased?

Drug level increased is found to be associated with 1,606 drugs and 1,096 conditions by eHealthMe. Currently, we are studying 18,176 people who have Drug level increased.

Number of Coreg and Drug level increased reports submitted per year:

Could Coreg cause Drug level increased?

Time on Coreg when people have Drug level increased *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Drug level increased when taking Coreg *:

  • female: 56.25 %
  • male: 43.75 %

Age of people who have Drug level increased when taking Coreg *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 7.14 %
  • 40-49: 7.14 %
  • 50-59: 28.57 %
  • 60+: 57.14 %

Common drugs people take besides Coreg *:

  1. Lasix: 3 people, 18.75%
  2. Lipitor: 3 people, 18.75%
  3. Digoxin: 3 people, 18.75%
  4. Allopurinol: 3 people, 18.75%
  5. Nexium: 3 people, 18.75%
  6. Synthroid: 3 people, 18.75%
  7. Rapamune: 2 people, 12.50%
  8. Crestor: 2 people, 12.50%
  9. Coumadin: 2 people, 12.50%
  10. Bactrim: 2 people, 12.50%

Common side effects people have besides Drug level increased *:

  1. Fatigue (feeling of tiredness): 6 people, 37.50%
  2. Rashes (redness): 5 people, 31.25%
  3. Malaise (a feeling of general discomfort or uneasiness): 4 people, 25.00%
  4. Hypotension (abnormally low blood pressure): 4 people, 25.00%
  5. Gait Disturbance: 3 people, 18.75%
  6. Dizziness: 3 people, 18.75%
  7. Renal Failure Acute (rapid kidney dysfunction): 3 people, 18.75%
  8. Feeling Abnormal: 3 people, 18.75%
  9. Depression: 3 people, 18.75%
  10. Hypoaesthesia (reduced sense of touch or sensation): 3 people, 18.75%

Common conditions people have *:

  1. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 12.50%
  2. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 2 people, 12.50%
  3. Electrocardiogram Qt Prolonged: 2 people, 12.50%
  4. High Blood Cholesterol: 2 people, 12.50%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.25%
  6. Breast Cancer Metastatic: 1 person, 6.25%
  7. Cardiac Disorder: 1 person, 6.25%
  8. Cardiac Failure Congestive: 1 person, 6.25%
  9. Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 1 person, 6.25%
  10. Diabetes: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Coreg and have Drug level increased?

Check whether Drug level increased is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Coreg side effects by duration, gender and age:

Drug level increased treatments and more:

Common drugs associated with Drug level increased:

All the drugs that are associated with Drug level increased:

Common conditions associated with Drug level increased:

All the conditions that are associated with Drug level increased:

How the study uses the data?

The study uses data from the FDA. It is based on carvedilol (the active ingredients of Coreg) and Coreg (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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