Cyclophosphamide and Pitting oedema - a phase IV clinical study of FDA data


Pitting oedema is found among people who take Cyclophosphamide, especially for people who are female, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Cyclophosphamide and have Pitting oedema. It is created by eHealthMe based on reports of 149,447 people who have side effects when taking Cyclophosphamide from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 20, 2022

149,447 people reported to have side effects when taking Cyclophosphamide.
Among them, 19 people (0.01%) have Pitting oedema.

What is Cyclophosphamide?

Cyclophosphamide has active ingredients of cyclophosphamide. It is often used in multiple myeloma. eHealthMe is studying from 149,590 Cyclophosphamide users for its effectiveness, alternative drugs and more.

What is Pitting oedema?

Pitting oedema (skin discoloration) is found to be associated with 756 drugs and 398 conditions by eHealthMe.

Number of Cyclophosphamide and Pitting oedema reports submitted per year:

Could Cyclophosphamide cause Pitting oedema?

Time on Cyclophosphamide when people have Pitting oedema *:

  • < 1 month: 57.14 %
  • 1 - 6 months: 42.86 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Pitting oedema when taking Cyclophosphamide *:

  • female: 52.63 %
  • male: 47.37 %

Age of people who have Pitting oedema when taking Cyclophosphamide *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 18.18 %
  • 20-29: 0.0 %
  • 30-39: 9.09 %
  • 40-49: 0.0 %
  • 50-59: 36.36 %
  • 60+: 36.36 %

Common drugs people take besides Cyclophosphamide *:

  1. Etoposide: 6 people, 31.58%
  2. Acyclovir: 5 people, 26.32%
  3. Adriamycin Pfs: 5 people, 26.32%
  4. Methotrexate: 4 people, 21.05%
  5. Lasix: 4 people, 21.05%
  6. Thalomid: 4 people, 21.05%
  7. Cisplatin: 4 people, 21.05%
  8. Dexamethasone: 4 people, 21.05%
  9. Megace: 3 people, 15.79%
  10. Diflucan: 3 people, 15.79%

Common side effects people have besides Pitting oedema *:

  1. Fatigue (feeling of tiredness): 10 people, 52.63%
  2. Oedema Peripheral (superficial swelling): 9 people, 47.37%
  3. Nausea (feeling of having an urge to vomit): 9 people, 47.37%
  4. White Blood Cell Count Decreased: 8 people, 42.11%
  5. Diarrhea: 7 people, 36.84%
  6. Haemoglobin Decreased: 7 people, 36.84%
  7. Pleural Effusion (water on the lungs): 6 people, 31.58%
  8. Nausea And Vomiting: 6 people, 31.58%
  9. C-Reactive Protein Increased: 5 people, 26.32%
  10. Hypotension (abnormally low blood pressure): 5 people, 26.32%

Common conditions people have *:

  1. Breast Cancer: 3 people, 15.79%
  2. Burkitt's Lymphoma (cancer of the lymphatic system): 2 people, 10.53%
  3. Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 2 people, 10.53%
  4. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.26%
  5. Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 1 person, 5.26%
  6. Non-Small Cell Lung Cancer Stage Iv: 1 person, 5.26%
  7. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Cyclophosphamide and have Pitting oedema?

Check whether Pitting oedema is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

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How severe was Pitting oedema and when was it recovered:

Expand to all the drugs that have ingredients of cyclophosphamide:

Alternative drugs to, pros and cons of Cyclophosphamide:

Common Cyclophosphamide side effects:

Browse all side effects of Cyclophosphamide:

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Pitting oedema treatments and more:

COVID vaccines that are related to Pitting oedema:

Common drugs associated with Pitting oedema:

All the drugs that are associated with Pitting oedema:

All the conditions that are associated with Pitting oedema:

How the study uses the data?

The study uses data from the FDA. It is based on cyclophosphamide (the active ingredients of Cyclophosphamide) and Cyclophosphamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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