Cycrin and Back pain aggravated - a phase IV clinical study of FDA data


We study 5,085 people who have side effects when taking Cycrin. Back pain aggravated is found, especially among people who are female, 50-59 old, have been taking the drug for 1 - 2 years, also take Premarin and have Menopause.

The phase IV clinical study analyzes which people take Cycrin and have Back pain aggravated. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 26, 2023

5,085 people reported to have side effects when taking Cycrin.
Among them, 28 people (0.55%) have Back pain aggravated.

What is Cycrin?

Cycrin has active ingredients of medroxyprogesterone acetate. Currently, eHealthMe is studying from 5,086 Cycrin users.

What is Back pain aggravated?

Back pain aggravated is found to be associated with 4,163 drugs and 1,766 conditions by eHealthMe. Currently, we are studying 152 people who have Back pain aggravated.

Number of Cycrin and Back pain aggravated reports submitted per year:

Could Cycrin cause Back pain aggravated?

Time on Cycrin when people have Back pain aggravated *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 16.67 %
  • 1 - 2 years: 44.44 %
  • 2 - 5 years: 33.33 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 5.56 %

Gender of people who have Back pain aggravated when taking Cycrin *:

  • female: 92.86 %
  • male: 7.14 %

Age of people who have Back pain aggravated when taking Cycrin *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 3.85 %
  • 50-59: 69.23 %
  • 60+: 26.92 %

Common drugs people take besides Cycrin *:

  1. Premarin: 23 people, 82.14%
  2. Provera: 21 people, 75.00%
  3. Estraderm: 20 people, 71.43%
  4. Prempro: 18 people, 64.29%
  5. Medroxyprogesterone Acetate: 12 people, 42.86%
  6. Lipitor: 7 people, 25.00%
  7. Fosamax: 7 people, 25.00%
  8. Advair Diskus 100/50: 6 people, 21.43%
  9. Zocor: 5 people, 17.86%
  10. Vivelle: 5 people, 17.86%

Common side effects people have besides Back pain aggravated *:

  1. Osteopenia (a condition where bone mineral density is lower than normal): 19 people, 67.86%
  2. Hot Flush (sudden feelings of heat): 16 people, 57.14%
  3. Headache (pain in head): 14 people, 50.00%
  4. Breast Lump (localized swelling that feels different from the surrounding breast tissue): 13 people, 46.43%
  5. Joint Pain: 12 people, 42.86%
  6. Depression: 12 people, 42.86%
  7. Spinal Osteoarthritis (joint cartilage loss in spine): 12 people, 42.86%
  8. Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 11 people, 39.29%
  9. Fatigue (feeling of tiredness): 11 people, 39.29%
  10. Breast Cancer: 10 people, 35.71%

Common conditions people have *:

  1. Menopause (end of monthly cycles in women): 7 people, 25.00%
  2. High Blood Cholesterol: 5 people, 17.86%
  3. Depression: 4 people, 14.29%
  4. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 3 people, 10.71%
  5. High Blood Pressure: 3 people, 10.71%
  6. Urinary Incontinence (inability to control the flow of urine and involuntary urination): 2 people, 7.14%
  7. Diabetes: 2 people, 7.14%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.14%
  9. Malaria (a parasitic disease due to mosquito bite): 2 people, 7.14%
  10. Menstrual Disorder (disease of menstrual cycle): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Cycrin and have Back pain aggravated?

Check whether Back pain aggravated is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Cycrin side effects by duration, gender and age:

Back pain aggravated treatments and more:

Common drugs associated with Back pain aggravated:

All the drugs that are associated with Back pain aggravated:

Common conditions associated with Back pain aggravated:

All the conditions that are associated with Back pain aggravated:

How the study uses the data?

The study uses data from the FDA. It is based on medroxyprogesterone acetate (the active ingredients of Cycrin) and Cycrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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