Depakene and Brain death - a phase IV clinical study of FDA data


Brain death is found among people who take Depakene, especially for people who are male, 50-59 old, have been taking the drug for 1 - 6 months.

The phase IV clinical study is created by eHealthMe based on reports of 14,449 people who have side effects when taking Depakene from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Nov, 24, 2022

14,449 people reported to have side effects when taking Depakene.
Among them, 8 people (0.06%) died.

What is Depakene?

Depakene has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 14,610 Depakene users for its effectiveness, alternative drugs and more.

Number of Depakene and Brain death reports submitted per year:

Could Depakene cause Brain death?

Time on Depakene when people died *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who died when taking Depakene *:

  • female: 50 %
  • male: 50 %

Age of people who died when taking Depakene *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 25.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 37.5 %
  • 50-59: 37.5 %
  • 60+: 0.0 %

Common drugs people take besides Depakene *:

  1. Symbicort: 3 people, 37.50%
  2. Blopress: 3 people, 37.50%
  3. Zoloft: 2 people, 25.00%
  4. Prednisone: 2 people, 25.00%
  5. Voltaren: 1 person, 12.50%
  6. Seroquel: 1 person, 12.50%
  7. Risperdal: 1 person, 12.50%
  8. Luvox: 1 person, 12.50%
  9. Foradil: 1 person, 12.50%
  10. Diazepam: 1 person, 12.50%

Common side effects people have before they died *:

  1. Cardiac Arrest: 4 people, 50.00%
  2. Thrombocytopenia (decrease of platelets in blood): 2 people, 25.00%
  3. Urinary Incontinence (inability to control the flow of urine and involuntary urination): 1 person, 12.50%
  4. The Flu (the flu is caused by an influenza virus): 1 person, 12.50%
  5. Pulmonary Infarction (death of a small area of lung): 1 person, 12.50%
  6. Heart Attack: 1 person, 12.50%
  7. General Physical Health Deterioration (weak health status): 1 person, 12.50%
  8. Fall: 1 person, 12.50%
  9. Fainting (loss of consciousness and postural tone): 1 person, 12.50%
  10. Extremity Necrosis (death of body tissue of arms and legs): 1 person, 12.50%

Common conditions people have *:

  1. Anaplastic Astrocytoma (tumour of the glial (supportive) tissue of the brain): 2 people, 25.00%
  2. Stress And Anxiety: 1 person, 12.50%
  3. Pain: 1 person, 12.50%
  4. Insomnia (sleeplessness): 1 person, 12.50%
  5. Impulsive Behavior: 1 person, 12.50%
  6. Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 1 person, 12.50%
  7. Epidural Anaesthesia: 1 person, 12.50%
  8. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 12.50%

* Approximation only. Some reports may have incomplete information.

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Expand to all the drugs that have ingredients of valproic acid:

Alternative drugs to, pros and cons of Depakene:

Common Depakene side effects:

Browse all side effects of Depakene:

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Common drugs associated with Brain death:

All the drugs that are associated with Brain death:

All the conditions that are associated with Brain death:

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Depakene) and Depakene (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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