Depakene and Conjunctivitis - a phase IV clinical study of FDA data


Conjunctivitis is found among people who take Depakene, especially for people who are female, 20-29 old, have been taking the drug for 6 - 12 months.

The phase IV clinical study analyzes which people take Depakene and have Conjunctivitis. It is created by eHealthMe based on reports of 14,449 people who have side effects when taking Depakene from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 03, 2022

14,449 people reported to have side effects when taking Depakene.
Among them, 54 people (0.37%) have Conjunctivitis.

What is Depakene?

Depakene has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 14,610 Depakene users for its effectiveness, alternative drugs and more.

What is Conjunctivitis?

Conjunctivitis (pink eye) is found to be associated with 2,044 drugs and 1,535 conditions by eHealthMe.

Number of Depakene and Conjunctivitis reports submitted per year:

Could Depakene cause Conjunctivitis?

Time on Depakene when people have Conjunctivitis *:

  • < 1 month: 7.69 %
  • 1 - 6 months: 15.38 %
  • 6 - 12 months: 23.08 %
  • 1 - 2 years: 23.08 %
  • 2 - 5 years: 7.69 %
  • 5 - 10 years: 15.38 %
  • 10+ years: 7.69 %

Gender of people who have Conjunctivitis when taking Depakene *:

  • female: 66.67 %
  • male: 33.33 %

Age of people who have Conjunctivitis when taking Depakene *:

  • 0-1: 0.0 %
  • 2-9: 11.54 %
  • 10-19: 9.62 %
  • 20-29: 34.62 %
  • 30-39: 13.46 %
  • 40-49: 5.77 %
  • 50-59: 5.77 %
  • 60+: 19.23 %

Common drugs people take besides Depakene *:

  1. Lamictal: 30 people, 55.56%
  2. Clonazepam: 5 people, 9.26%
  3. Lamotrigine: 5 people, 9.26%
  4. Belsomra: 3 people, 5.56%
  5. Carbocaine: 3 people, 5.56%
  6. Zolpidem Tartrate: 2 people, 3.70%
  7. Solu-Medrol: 2 people, 3.70%
  8. Dexamethasone Sodium Phosphate: 2 people, 3.70%
  9. Folic Acid: 2 people, 3.70%
  10. Heparin-Fraction, Sodium Salt: 2 people, 3.70%

Common side effects people have besides Conjunctivitis *:

  1. Erythema Multiforme (a type of hypersensitivity reaction): 32 people, 59.26%
  2. Fever: 32 people, 59.26%
  3. Rashes (redness): 14 people, 25.93%
  4. Mouth Ulcers: 12 people, 22.22%
  5. Skin Disorder (skin disease): 10 people, 18.52%
  6. Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 10 people, 18.52%
  7. Eye Discharge: 9 people, 16.67%
  8. Keratitis (eye's cornea, the front part of the eye, becomes inflamed): 9 people, 16.67%
  9. Swallowing Difficulty: 8 people, 14.81%
  10. Photophobia (extreme sensitivity to light): 8 people, 14.81%

Common conditions people have *:

  1. Myoclonic Epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs): 3 people, 5.56%
  2. Insomnia (sleeplessness): 3 people, 5.56%
  3. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 2 people, 3.70%
  4. Oligodendroglioma (a type of glioma that are believed to originate from the oligodendrocytes of the brain or from a glial precursor cell): 2 people, 3.70%
  5. Upper Respiratory Tract Inflammation: 1 person, 1.85%
  6. Bipolar Ii Disorder (characterized by at least one episode of hypomania and at least one episode of major depression): 1 person, 1.85%
  7. Birth Control: 1 person, 1.85%
  8. Breast Cancer: 1 person, 1.85%
  9. Chest Pain: 1 person, 1.85%
  10. Constipation: 1 person, 1.85%

* Approximation only. Some reports may have incomplete information.

Do you take Depakene and have Conjunctivitis?

Check whether Conjunctivitis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Conjunctivitis and when was it recovered:

Expand to all the drugs that have ingredients of valproic acid:

Alternative drugs to, pros and cons of Depakene:

Common Depakene side effects:

Browse all side effects of Depakene:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Conjunctivitis treatments and more:

COVID vaccines that are related to Conjunctivitis:

Common drugs associated with Conjunctivitis:

All the drugs that are associated with Conjunctivitis:

Common conditions associated with Conjunctivitis:

All the conditions that are associated with Conjunctivitis:

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Depakene) and Depakene (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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