Depakene and Dupuytren's contracture - a phase IV clinical study of FDA data
Dupuytren's contracture is found among people who take Depakene, especially for people who are male, 60+ old.
The phase IV clinical study analyzes which people take Depakene and have Dupuytren's contracture. It is created by eHealthMe based on reports of 14,449 people who have side effects when taking Depakene from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
14,449 people reported to have side effects when taking Depakene.
Among them, 6 people (0.04%) have Dupuytren's contracture.
What is Depakene?
Depakene has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 14,492 Depakene users for its effectiveness, alternative drugs and more.
What is Dupuytren's contracture?
Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 445 drugs and 208 conditions by eHealthMe.
Number of Depakene and Dupuytren's contracture reports submitted per year:
Gender of people who have Dupuytren's contracture when taking Depakene *:
- female: 33.33 %
- male: 66.67 %
Age of people who have Dupuytren's contracture when taking Depakene *:
- 0-1: 0.0 %
- 2-9: 0.0 %
- 10-19: 0.0 %
- 20-29: 0.0 %
- 30-39: 0.0 %
- 40-49: 25 %
- 50-59: 25 %
- 60+: 50 %
Common drugs people take besides Depakene *:
- Depakote: 2 people, 33.33%
- Venlafaxine Hydrochloride: 1 person, 16.67%
Common side effects people have besides Dupuytren's contracture *:
- Thirst: 2 people, 33.33%
- Road Traffic Accident: 2 people, 33.33%
- Partial Seizures (seizures which affect only a part of the brain at onset): 2 people, 33.33%
- Neuralgia (pain in one or more nerves): 2 people, 33.33%
- Nerve Degeneration (weakness in functioning of nerve due to degeneration): 2 people, 33.33%
- Micturition Urgency (urgency to pass the urine): 2 people, 33.33%
- Joint Crepitation: 2 people, 33.33%
- Fainting (loss of consciousness and postural tone): 2 people, 33.33%
- Drug Ineffective: 2 people, 33.33%
- Burning Sensation: 2 people, 33.33%
Common conditions people have *:
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 33.33%
* Approximation only. Some reports may have incomplete information.
Do you take Depakene and have Dupuytren's contracture?Check whether Dupuytren's contracture is associated with a drug or a condition
How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Gupta E, Kunjal R, Cury JD, "Severe hyponatremia due to valproic acid toxicity", Journal of clinical medicine research, 2015 Jan .
- Hwabejire JO, Lu J, Liu B, Li Y, Halaweish I, Alam HB, "Valproic acid for the treatment of hemorrhagic shock: a dose-optimization study", journal of surgical research, 2014 Jan .
How severe was Dupuytren's contracture and when was it recovered:
Expand to all the drugs that have ingredients of valproic acid:
Alternative drugs to, pros and cons of Depakene:
- Depakene (14,492 reports)
Common Depakene side effects:
Browse all side effects of Depakene:a b c d e f g h i j k l m n o p q r s t u v w x y z
Dupuytren's contracture treatments and more:
- Dupuytren's contracture (2,031 reports)
COVID vaccines that are related to Dupuytren's contracture:
- Dupuytren's contracture in Moderna COVID Vaccine
- Dupuytren's contracture in Pfizer BioNTech Covid Vaccine
- Dupuytren's contracture in Johnson and Johnson Covid Vaccine
Common drugs associated with Dupuytren's contracture:
- Xiaflex: 137 reports
All the drugs that are associated with Dupuytren's contracture:
- Dupuytren's contracture (445 drugs)
Common conditions associated with Dupuytren's contracture:
- Ra: 104 reports
All the conditions that are associated with Dupuytren's contracture:
- Dupuytren's contracture (208 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on valproic acid (the active ingredients of Depakene) and Depakene (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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