Depakene and Sick sinus syndrome - a phase IV clinical study of FDA data

Summary:

Sick sinus syndrome is reported only by a few people who take Depakene.

The phase IV clinical study analyzes which people take Depakene and have Sick sinus syndrome. It is created by eHealthMe based on reports of 14,449 people who have side effects while taking Depakene from the FDA, and is updated regularly.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.



On Jan, 24, 2023

14,449 people reported to have side effects when taking Depakene.
Among them, 4 people (0.03%) have Sick sinus syndrome.


What is Depakene?

Depakene has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 14,610 Depakene users for its effectiveness, alternative drugs and more.

What is Sick sinus syndrome?

Sick sinus syndrome (a collection of heart rhythm disorders) is found to be associated with 1,314 drugs and 738 conditions by eHealthMe.

Number of Depakene and Sick sinus syndrome reports submitted per year:

Could Depakene cause Sick sinus syndrome?

Gender of people who have Sick sinus syndrome when taking Depakene *:

  • female: 50 %
  • male: 50 %

Age of people who have Sick sinus syndrome when taking Depakene *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 50 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 25 %
  • 60+: 25 %

Common drugs people take besides Depakene *:

  1. Lamictal: 2 people, 50.00%
  2. Valproic Acid: 1 person, 25.00%
  3. Tegretol: 1 person, 25.00%
  4. Lasix: 1 person, 25.00%
  5. Blopress: 1 person, 25.00%
  6. Aricept: 1 person, 25.00%
  7. Amlodipine: 1 person, 25.00%

Common side effects people have besides Sick sinus syndrome *:

  1. Fall: 2 people, 50.00%
  2. Arrhythmias (irregular heartbeat): 2 people, 50.00%
  3. Quadriplegia (a four limb paralysis): 1 person, 25.00%
  4. Eye Movement Disorder: 1 person, 25.00%
  5. Atrial Tachycardia (rhythm disturbance that arises in the atria): 1 person, 25.00%
  6. Bradycardia (abnormally slow heart action): 1 person, 25.00%
  7. Cardiac Murmur (an heart sound in valve abnormality): 1 person, 25.00%
  8. Carnitine Decreased: 1 person, 25.00%
  9. Electroencephalogram Abnormal: 1 person, 25.00%
  10. Enlarged Heart: 1 person, 25.00%

Common conditions people have *:

  1. Gastrointestinal Motility Disorder (abnormal intestinal contractions): 1 person, 25.00%
  2. Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 1 person, 25.00%
  3. Constipation: 1 person, 25.00%
  4. Carnitine Deficiency: 1 person, 25.00%
  5. Cardiac Hypertrophy (thickening of the heart muscle): 1 person, 25.00%

* Approximation only. Some reports may have incomplete information.

Do you take Depakene and have Sick sinus syndrome?

Check whether Sick sinus syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



Related publications that referenced our studies

Related studies

How severe was Sick sinus syndrome and when was it recovered:

Expand to all the drugs that have ingredients of valproic acid:

Alternative drugs to, pros and cons of Depakene:

Common Depakene side effects:

Browse all side effects of Depakene:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sick sinus syndrome treatments and more:

COVID vaccines that are related to Sick sinus syndrome:

Common drugs associated with Sick sinus syndrome:

All the drugs that are associated with Sick sinus syndrome:

Common conditions associated with Sick sinus syndrome:

All the conditions that are associated with Sick sinus syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Depakene) and Depakene (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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