Depakote and Aphagia - a phase IV clinical study of FDA data

Summary:

We study 51,553 people who have side effects when taking Depakote. Aphagia is found, especially among people who are female, 60+ old, have been taking the drug for < 1 month, also take Seroquel and have Stress and anxiety.

The phase IV clinical study analyzes which people take Depakote and have Aphagia. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 29, 2023

51,553 people reported to have side effects when taking Depakote.
Among them, 27 people (0.05%) have Aphagia.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is used in bipolar disorder. Currently, eHealthMe is studying from 54,472 Depakote users.

What is Aphagia?

Aphagia (inability or refusal to swallow) is found to be associated with 1,343 drugs and 1,006 conditions by eHealthMe. Currently, we are studying 6,476 people who have Aphagia.

Number of Depakote and Aphagia reports submitted per year:

Time on Depakote when people have Aphagia *:

Gender of people who have Aphagia when taking Depakote *:

female: 70.37 %
male: 29.63 %

Age of people who have Aphagia when taking Depakote *:

Common drugs people take besides Depakote *:

Common side effects people have besides Aphagia *:

Insomnia (sleeplessness): 12 people, 44.44%
Malaise (a feeling of general discomfort or uneasiness): 10 people, 37.04%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 8 people, 29.63%
Nausea And Vomiting: 7 people, 25.93%
Drug Ineffective: 7 people, 25.93%
Head Injury: 7 people, 25.93%
Stress And Anxiety: 7 people, 25.93%
High Blood Pressure: 6 people, 22.22%
Pain: 6 people, 22.22%
Nausea (feeling of having an urge to vomit): 6 people, 22.22%

Common conditions people have *:

Stress And Anxiety: 7 people, 25.93%
Depression: 5 people, 18.52%
Headache (pain in head): 5 people, 18.52%
Pain: 4 people, 14.81%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 14.81%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 11.11%
Sleep Disorder: 3 people, 11.11%
Insomnia (sleeplessness): 3 people, 11.11%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 11.11%
Grand Mal Convulsion (a type of generalized seizure that affects the entire brain): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Depakote and have Aphagia?

Check whether Aphagia is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Depakote side effects by duration, gender and age:

Depakote side effects (54,472 reports)

Aphagia treatments and more:

Aphagia (6,476 reports)

Common drugs associated with Aphagia:

All the drugs that are associated with Aphagia:

Aphagia (1,343 drugs)

Common conditions associated with Aphagia:

Multiple sclerosis: 636 reports
Gastroesophageal reflux disease: 324 reports
Depression: 258 reports
High blood pressure: 255 reports
Pain: 248 reports
High blood cholesterol: 189 reports
Stress and anxiety: 183 reports
Osteoporosis: 169 reports
Rheumatoid arthritis: 168 reports

All the conditions that are associated with Aphagia:

Aphagia (1,006 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Depakote) and Depakote (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.