Depakote and Dupuytren's contracture - a phase IV clinical study of FDA data
Dupuytren's contracture is reported only by a few people who take Depakote.
The phase IV clinical study analyzes which people take Depakote and have Dupuytren's contracture. It is created by eHealthMe based on reports of 47,968 people who have side effects while taking Depakote from the FDA, and is updated regularly.
With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.
47,968 people reported to have side effects when taking Depakote.
Among them, 5 people (0.01%) have Dupuytren's contracture.
What is Depakote?
Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 50,780 Depakote users for its effectiveness, alternative drugs and more.
What is Dupuytren's contracture?
Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 441 drugs and 204 conditions by eHealthMe.
Number of Depakote and Dupuytren's contracture reports submitted per year:
Time on Depakote when people have Dupuytren's contracture *:
- < 1 month: 0.0 %
- 1 - 6 months: 0.0 %
- 6 - 12 months: 0.0 %
- 1 - 2 years: 0.0 %
- 2 - 5 years: 0.0 %
- 5 - 10 years: 100 %
- 10+ years: 0.0 %
Gender of people who have Dupuytren's contracture when taking Depakote *:
- female: 60 %
- male: 40 %
Age of people who have Dupuytren's contracture when taking Depakote *:
- 0-1: 0.0 %
- 2-9: 0.0 %
- 10-19: 0.0 %
- 20-29: 0.0 %
- 30-39: 0.0 %
- 40-49: 0.0 %
- 50-59: 25 %
- 60+: 75 %
Common drugs people take besides Depakote *:
- Depakene: 2 people, 40.00%
- Zoloft: 1 person, 20.00%
- Wellbutrin Sr: 1 person, 20.00%
- Vitamin D3: 1 person, 20.00%
- Venlafaxine Hydrochloride: 1 person, 20.00%
- Sertraline: 1 person, 20.00%
- Seroquel: 1 person, 20.00%
- Pramipexole Dihydrochloride: 1 person, 20.00%
- Fish Oil: 1 person, 20.00%
- Ergocalciferol: 1 person, 20.00%
Common side effects people have besides Dupuytren's contracture *:
- Weight Increased: 2 people, 40.00%
- Tremor (trembling or shaking movements in one or more parts of your body): 2 people, 40.00%
- Weakness: 2 people, 40.00%
- Anger: 1 person, 20.00%
- Fall: 1 person, 20.00%
- Hearing Loss: 1 person, 20.00%
- Hair Loss: 1 person, 20.00%
- Gynecomastia (enlargement of the gland tissue of the male breast): 1 person, 20.00%
- Gingival Bleeding (bleeding gums): 1 person, 20.00%
- Gait Disturbance: 1 person, 20.00%
Common conditions people have *:
- Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 20.00%
- Depression: 1 person, 20.00%
* Approximation only. Some reports may have incomplete information.
Do you take Depakote and have Dupuytren's contracture?Check whether Dupuytren's contracture is associated with a drug or a condition
How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Alternative drugs to, pros and cons of Depakote:
- Depakote (50,780 reports)
Dupuytren's contracture treatments and more:
- Dupuytren's contracture (2,031 reports)
COVID vaccines that are related to Dupuytren's contracture:
- Dupuytren's contracture in Moderna COVID Vaccine
- Dupuytren's contracture in Pfizer BioNTech Covid Vaccine
- Dupuytren's contracture in Johnson and Johnson Covid Vaccine
How severe was Dupuytren's contracture and when was it recovered:
Expand to all the drugs that have ingredients of divalproex sodium:
Common drugs associated with Dupuytren's contracture:
- Xiaflex: 137 reports
All the drugs that are associated with Dupuytren's contracture:
- Dupuytren's contracture (441 drugs)
All the conditions that are associated with Dupuytren's contracture:
- Dupuytren's contracture (204 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Depakote) and Depakote (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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