Depo-medrol and Appendix disorder - a phase IV clinical study of FDA data


We study 5,626 people who have side effects when taking Depo-medrol. Appendix disorder is found, especially among people who are female, 50-59 old, also take Fosamax and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people take Depo-medrol and have Appendix disorder. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 26, 2023

5,626 people reported to have side effects when taking Depo-medrol.
Among them, 12 people (0.21%) have Appendix disorder.

What is Depo-medrol?

Depo-medrol has active ingredients of methylprednisolone acetate. It is used in birth control. Currently, eHealthMe is studying from 5,712 Depo-medrol users.

What is Appendix disorder?

Appendix disorder is found to be associated with 711 drugs and 376 conditions by eHealthMe. Currently, we are studying 2,021 people who have Appendix disorder.

Number of Depo-medrol and Appendix disorder reports submitted per year:

Could Depo-medrol cause Appendix disorder?

Gender of people who have Appendix disorder when taking Depo-medrol *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Appendix disorder when taking Depo-medrol *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 100 %
  • 60+: 0.0 %

Common drugs people take besides Depo-medrol *:

  1. Actemra: 6 people, 50.00%
  2. Enbrel: 6 people, 50.00%
  3. Restasis: 6 people, 50.00%
  4. Xeljanz Xr: 6 people, 50.00%
  5. Fosamax: 6 people, 50.00%
  6. Lifitegrast: 5 people, 41.67%
  7. Alendronate Sodium: 5 people, 41.67%
  8. Folic Acid: 2 people, 16.67%
  9. Valsartan: 2 people, 16.67%
  10. Methotrexate: 2 people, 16.67%

Common side effects people have besides Appendix disorder *:

  1. Irritable Bowel Syndrome: 6 people, 50.00%
  2. Carpal Tunnel Syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 6 people, 50.00%
  3. Hoarseness Or Changing Voice: 5 people, 41.67%
  4. Heart Palpitations (feelings or sensations that your heart is pounding or racing): 5 people, 41.67%
  5. Bone Disorder: 5 people, 41.67%
  6. Device Failure: 5 people, 41.67%
  7. Broken Bone: 5 people, 41.67%
  8. Low Turnover Osteopathy (slow removal of old bone and its replacement by new bone): 5 people, 41.67%
  9. Insomnia (sleeplessness): 5 people, 41.67%
  10. Vitamin B12 Deficiency: 5 people, 41.67%

Common conditions people have *:

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 50.00%
  2. Osteoporosis (bones weak and more likely to break): 5 people, 41.67%
  3. Osteopenia (a condition where bone mineral density is lower than normal): 5 people, 41.67%

* Approximation only. Some reports may have incomplete information.

Do you take Depo-medrol and have Appendix disorder?

Check whether Appendix disorder is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Depo-medrol side effects by duration, gender and age:

Appendix disorder treatments and more:

Common drugs associated with Appendix disorder:

All the drugs that are associated with Appendix disorder:

Common conditions associated with Appendix disorder:

All the conditions that are associated with Appendix disorder:

How the study uses the data?

The study uses data from the FDA. It is based on methylprednisolone acetate (the active ingredients of Depo-medrol) and Depo-medrol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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