Desyrel and Dupuytren's contracture - a phase IV clinical study of FDA data


Dupuytren's contracture is found among people who take Desyrel, especially for people who are male, 50-59 old.

The phase IV clinical study analyzes which people take Desyrel and have Dupuytren's contracture. It is created by eHealthMe based on reports of 5,609 people who have side effects when taking Desyrel from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 17, 2022

5,609 people reported to have side effects when taking Desyrel.
Among them, 6 people (0.11%) have Dupuytren's contracture.

What is Desyrel?

Desyrel has active ingredients of trazodone hydrochloride. It is often used in insomnia. eHealthMe is studying from 5,873 Desyrel users for its effectiveness, alternative drugs and more.

What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 445 drugs and 208 conditions by eHealthMe.

Number of Desyrel and Dupuytren's contracture reports submitted per year:

Could Desyrel cause Dupuytren's contracture?

Gender of people who have Dupuytren's contracture when taking Desyrel *:

  • female: 0.0 %
  • male: 100 %

Age of people who have Dupuytren's contracture when taking Desyrel *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 83.33 %
  • 60+: 16.67 %

Common drugs people take besides Desyrel *:

  1. Zometa: 6 people, 100.00%
  2. Lisinopril: 6 people, 100.00%
  3. Ambien: 6 people, 100.00%
  4. Taxotere: 6 people, 100.00%
  5. Casodex: 6 people, 100.00%
  6. Leuprolide Acetate: 6 people, 100.00%
  7. Plavix: 6 people, 100.00%
  8. Oxycontin: 6 people, 100.00%
  9. Neupogen: 6 people, 100.00%
  10. Motrin: 6 people, 100.00%

Common side effects people have besides Dupuytren's contracture *:

  1. Activities Of Daily Living Impaired: 6 people, 100.00%
  2. Haemochromatosis (body to absorb more iron than usual from food): 6 people, 100.00%
  3. Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 6 people, 100.00%
  4. Coronary Heart Disease (narrowing or blockage of the coronary arteries): 6 people, 100.00%
  5. Breathing Difficulty: 6 people, 100.00%
  6. Injury: 6 people, 100.00%
  7. Hypotension (abnormally low blood pressure): 6 people, 100.00%
  8. Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 6 people, 100.00%
  9. Herpes Simplex (herpes simplex is a common viral infection): 6 people, 100.00%
  10. Urinary Incontinence (inability to control the flow of urine and involuntary urination): 6 people, 100.00%

Common conditions people have *:

  1. Bone Density Decreased: 5 people, 83.33%
  2. Metastases To Bone (cancer spreads to bone): 1 person, 16.67%
  3. Colon Cancer: 1 person, 16.67%
  4. Bone Loss: 1 person, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Desyrel and have Dupuytren's contracture?

Check whether Dupuytren's contracture is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Dupuytren's contracture and when was it recovered:

Expand to all the drugs that have ingredients of trazodone hydrochloride:

Alternative drugs to, pros and cons of Desyrel:

Common Desyrel side effects:

Browse all side effects of Desyrel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Dupuytren's contracture treatments and more:

COVID vaccines that are related to Dupuytren's contracture:

Common drugs associated with Dupuytren's contracture:

All the drugs that are associated with Dupuytren's contracture:

Common conditions associated with Dupuytren's contracture:

  • Ra: 104 reports

All the conditions that are associated with Dupuytren's contracture:

How the study uses the data?

The study uses data from the FDA. It is based on trazodone hydrochloride (the active ingredients of Desyrel) and Desyrel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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