Diclofenac and Systemic lupus erythematosus - a phase IV clinical study of FDA data

• Diclofenac (22,929 reports)

• Abdominal discomfort: 1,486 reports
• Abdominal distension: 166 reports
• Abdominal pain: 611 reports
• Abdominal pain upper: 708 reports
• Acute kidney failure: 665 reports
• Adverse drug reaction: 257 reports
• Adverse event: 110 reports
• Agitation (state of anxiety or nervous excitement): 159 reports
• Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 117 reports
• Alanine aminotransferase increased: 127 reports
• Anaemia (lack of blood): 456 reports
• Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 467 reports
• Angioedema (rapid swelling of the dermis): 260 reports
• Ankylosing spondylitis (type of arthritis affecting the spine): 375 reports
• Anti-cyclic citrullinated peptide antibody positive: 582 reports
• Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 548 reports
• Arrhythmias (irregular heartbeat): 209 reports
• Arthritis (form of joint disorder that involves inflammation of one or more joints): 352 reports
• Arthropathy: 969 reports
• Asthma: 181 reports
• Back pain: 807 reports
• Balance disorder: 166 reports
• Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 334 reports
• Blood creatinine increased: 162 reports
• Blood pressure systolic increased: 172 reports
• Bone density decreased: 244 reports
• Bone pain: 145 reports
• Breathing difficulty: 1,130 reports
• Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 202 reports
• Cardiac failure: 105 reports
• Cataract (clouding of the lens inside the eye): 176 reports
• Chest pain: 601 reports
• Chills (felling of cold): 220 reports
• Chronic kidney disease: 932 reports
• Confusional state: 333 reports
• Constipation: 440 reports
• Cough: 592 reports
• Deafness transitory (deafness temporary): 117 reports
• Death: 303 reports
• Dehydration (dryness resulting from the removal of water): 166 reports
• Delirium (wild excitement): 108 reports
• Depressed mood: 118 reports
• Depression: 608 reports
• Diarrhea: 1,147 reports
• Discomfort: 839 reports
• Disease progression: 189 reports
• Dizziness: 1,336 reports
• Drowsiness: 487 reports
• Drug abuse and dependence: 160 reports
• Drug hypersensitivity: 647 reports
• Drug ineffective: 3,736 reports
• Drug intolerance (drug sensitivity): 1,397 reports
• Dry eyes (lack of adequate tears): 211 reports
• Dry mouth: 184 reports
• Duodenal ulcer perforation (untreated ulcer can burn through the wall of the stomach): 385 reports
• Dysstasia (difficulty in standing): 102 reports
• Emotional distress: 181 reports
• Erythema multiforme (a type of hypersensitivity reaction): 122 reports
• Eye pain: 101 reports
• Fainting (loss of consciousness and postural tone): 194 reports
• Fall: 679 reports
• Fatigue (feeling of tiredness): 2,523 reports
• Feeling hot: 104 reports
• Fever: 734 reports
• Fibromyalgia (a long-term condition which causes pain all over the body): 304 reports
• Gait disturbance: 523 reports
• Gastric disorder (disease of stomach): 136 reports
• Gastric ulcer (stomach ulcer): 345 reports
• Gastritis (inflammation of stomach): 120 reports
• Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection): 103 reports
• Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 242 reports
• Gastrointestinal disorder (functional problems of gastrointestinal tract): 419 reports
• Gastrointestinal haemorrhage (bleeding gastrointestinal tract): 258 reports
• Gastrointestinal pain: 155 reports
• General physical health deterioration (weak health status): 664 reports
• Glossodynia (a burning or painful sensation in the tongue): 887 reports
• Haematochezia (passage of stools containing blood): 242 reports
• Haemoglobin decreased: 202 reports
• Haemorrhage (bleeding): 127 reports
• Hair loss: 1,430 reports
• Hand deformity: 884 reports
• Headache (pain in head): 2,306 reports
• Head injury: 382 reports
• Hearing loss: 146 reports
• Heart attack: 121 reports
• Heart palpitations (feelings or sensations that your heart is pounding or racing): 190 reports
• Heart rate decreased: 194 reports
• Heart rate increased: 168 reports
• Helicobacter infection (helicobacter pylori (h. pylori) infects stomach): 367 reports
• Hepatic enzyme increased: 699 reports
• Herpes zoster: 255 reports
• High blood cholesterol: 280 reports
• High blood pressure: 936 reports
• Hip joint replacement: 204 reports
• Hot flush (sudden feelings of heat): 112 reports
• Hyperhidrosis (abnormally increased sweating): 295 reports
• Hyperkalemia (damage to or disease of the kidney): 192 reports
• Hypersensitivity: 1,119 reports
• Hypoaesthesia (reduced sense of touch or sensation): 395 reports
• Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 159 reports
• Hypophagia (reduced food intake): 176 reports
• Hypotension (abnormally low blood pressure): 464 reports
• Ill-defined disorder: 158 reports
• Impaired healing: 164 reports
• Indigestion: 299 reports
• Infection: 820 reports
• Inflammation: 254 reports
• Influenza like illness: 158 reports
• Infusion related reaction: 905 reports
• Injection site pain: 185 reports
• Injury: 142 reports
• Insomnia (sleeplessness): 423 reports
• Intentional self-injury: 124 reports
• Interstitial nephritis (inflammation of the kidney): 182 reports
• Irritable bowel syndrome: 156 reports
• Itching: 718 reports
• Joint pain: 1,983 reports
• Joint range of motion decreased (disease of joint movement): 150 reports
• Joint stiffness: 151 reports
• Joint swelling: 1,357 reports
• Kidney stones: 154 reports
• Knee joint replacement: 478 reports
• Liver disorder (liver diseases): 148 reports
• Loss of consciousness: 199 reports
• Lower respiratory tract infection: 285 reports
• Lymphoma (cancer that begins in immune system cells): 211 reports
• Malaise (a feeling of general discomfort or uneasiness): 1,120 reports
• Maternal exposure during pregnancy (use of substance during pregnancy): 868 reports
• Melaena (the passage of black, tarry stools): 205 reports
• Memory loss: 352 reports
• Migraine (headache): 237 reports
• Mobility decreased (ability to move is reduced): 471 reports
• Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 159 reports
• Muscle aches (muscle pain): 445 reports
• Muscle injury: 108 reports
• Muscle spasms (muscle contraction): 538 reports
• Muscle twitching: 114 reports
• Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 363 reports
• Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 1,071 reports
• Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 134 reports
• Nasopharyngitis (inflammation of the nasopharynx): 681 reports
• Nausea (feeling of having an urge to vomit): 1,593 reports
• Nausea and vomiting: 1,153 reports
• Neck pain: 303 reports
• Nephrogenic anaemia (anaemia due to kidney disease): 121 reports
• Nervousness: 127 reports
• Neuralgia (pain in one or more nerves): 123 reports
• Oedema (fluid collection in tissue): 132 reports
• Oedema peripheral (superficial swelling): 246 reports
• Onychoclasis (breaking of the nails): 157 reports
• Oropharyngeal pain: 323 reports
• Osteoarthritis (a joint disease caused by cartilage loss in a joint): 346 reports
• Osteoporosis (bones weak and more likely to break): 165 reports
• Otitis (ear infection): 308 reports
• Overdose: 248 reports
• Pain: 2,927 reports
• Pain in extremity: 1,148 reports
• Pain in jaw: 122 reports
• Paleness (unusual lightness of skin colour): 112 reports
• Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 316 reports
• Pemphigus (any of several acute or chronic skin diseases characterized by groups of itching blisters): 1,035 reports
• Pericarditis (inflammation of the pericardium): 736 reports
• Peripheral swelling: 756 reports
• Pharyngitis (inflammation of the pharynx, causing a sore throat): 228 reports
• Pleural effusion (water on the lungs): 111 reports
• Pneumonia: 672 reports
• Productive cough: 154 reports
• Psoriasis (immune-mediated disease that affects the skin): 347 reports
• Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 398 reports
• Pulmonary oedema (fluid accumulation in the lungs): 106 reports
• Rash erythematous (redness of the skin): 120 reports
• Rashes (redness): 1,955 reports
• Rash pruritic (redness with itching): 210 reports
• Renal impairment (severely reduced kidney function): 261 reports
• Renal injury (kidney injury): 232 reports
• Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 132 reports
• Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 101 reports
• Rheumatic fever (an inflammatory disease that occurs following a streptococcus pyogenes infection): 137 reports
• Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints): 2,129 reports
• Rheumatoid factor positive: 383 reports
• Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 141 reports
• Seizures (abnormal excessive or synchronous neuronal activity in the brain): 130 reports
• Sepsis (a severe blood infection that can lead to organ failure and death): 179 reports
• Sinusitis (inflammation of sinus): 418 reports
• Skin blushing/flushing (a sudden reddening of the face, neck): 172 reports
• Sleep disorder: 702 reports
• Speech disorder: 139 reports
• Spinal pain (pain in spine): 177 reports
• Stomatitis (inflammation of mucous membrane of mouth): 180 reports
• Stress and anxiety: 659 reports
• Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 120 reports
• Suicidal ideation: 142 reports
• Swallowing difficulty: 147 reports
• Swelling: 997 reports
• Synovial cyst (cyst of joint filled with synovial fluid): 155 reports
• Synovitis (inflammation of the synovial membrane): 919 reports
• Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1,052 reports
• Tenosynovitis (inflammation of the fluid-filled sheath (called the synovium) that surrounds a tendon): 164 reports
• The flu (the flu is caused by an influenza virus): 341 reports
• Therapeutic response decreased (less preventive response): 160 reports
• Thrombocytopenia (decrease of platelets in blood): 266 reports
• Tooth loss: 201 reports
• Tremor (trembling or shaking movements in one or more parts of your body): 296 reports
• Urinary tract infection: 497 reports
• Urticaria (rash of round, red welts on the skin that itch intensely): 409 reports
• Viral upper respiratory tract infection: 134 reports
• Vision blurred: 147 reports
• Visual impairment: 175 reports
• Weakness: 1,200 reports
• Weight decreased: 761 reports
• Weight increased: 505 reports
• Wheezing (a high-pitched whistling sound made while you breath): 133 reports
• White blood cell count decreased: 153 reports
• Wound: 758 reports

• Systemic lupus erythematosus (52,473 reports)

• Accutane: 240 reports
• Acetaminophen: 105 reports
• Acetylsalicylic acid: 150 reports
• Actemra: 3,746 reports
• Actonel: 108 reports
• Adcirca: 146 reports
• Albuterol: 187 reports
• Alendronate sodium: 925 reports
• Alendronic acid: 1,006 reports
• Allopurinol: 128 reports
• Alprazolam: 169 reports
• Ambien: 202 reports
• Amlodipine: 317 reports
• Arava: 3,784 reports
• Asacol: 122 reports
• Aspirin: 523 reports
• Atenolol: 202 reports
• Ativan: 166 reports
• Avonex: 260 reports
• Azathioprine: 628 reports
• Baclofen: 150 reports
• Benadryl: 196 reports
• Benlysta: 1,148 reports
• Bupropion hydrochloride: 107 reports
• Calcium: 334 reports
• Celebrex: 540 reports
• Cellcept: 362 reports
• Cetirizine hydrochloride: 2,793 reports
• Cimzia: 3,666 reports
• Clonazepam: 200 reports
• Clonidine: 105 reports
• Cortisone acetate: 2,257 reports
• Cosentyx: 255 reports
• Coumadin: 265 reports
• Crestor: 135 reports
• Cyclophosphamide: 162 reports
• Cymbalta: 297 reports
• Desoximetasone: 2,431 reports
• Dexamethasone: 106 reports
• Diazepam: 131 reports
• Diclofenac: 1,052 reports
• Diclofenac sodium: 1,439 reports
• Diovan: 117 reports
• Diphen: 167 reports
• Effexor: 171 reports
• Eliquis: 107 reports
• Enbrel: 5,060 reports
• Exidine: 131 reports
• Famotidine: 104 reports
• Fish oil: 114 reports
• Flexeril: 132 reports
• Flonase: 126 reports
• Fluoxetine: 101 reports
• Folic acid: 363 reports
• Forteo: 211 reports
• Fosamax: 3,401 reports
• Furosemide: 307 reports
• Gabapentin: 361 reports
• Humalog: 101 reports
• Humira: 6,804 reports
• Hydramine: 166 reports
• Hydrochlorothiazide: 214 reports
• Hydroxychloroquine sulfate: 3,017 reports
• Ibu: 1,668 reports
• Ibuprofen: 461 reports
• Imuran: 313 reports
• Keppra: 124 reports
• Kevzara: 351 reports
• Klonopin: 136 reports
• Lamictal: 141 reports
• Lansoprazole: 144 reports
• Lantus: 107 reports
• Lasix: 366 reports
• Leflunomide: 1,376 reports
• Letairis: 209 reports
• Levaquin: 113 reports
• Levothyroxine sodium: 149 reports
• Lexapro: 133 reports
• Lipitor: 294 reports
• Lisinopril: 348 reports
• Lopurin: 128 reports
• Loraz: 278 reports
• Lorazepam: 147 reports
• Losartan: 169 reports
• Lyrica: 606 reports
• Magnesium: 142 reports
• Medrol: 141 reports
• Meloxicam: 138 reports
• Metformin: 281 reports
• Methotrexate: 5,513 reports
• Methotrexate sodium: 825 reports
• Morphine: 136 reports
• Mycophenolate mofetil: 368 reports
• Naproxen: 221 reports
• Neurontin: 239 reports
• Nexium: 398 reports
• Nifedipine: 101 reports
• Norco: 101 reports
• Norvasc: 168 reports
• Nuvaring: 106 reports
• Omeprazole: 517 reports
• Opsumit: 208 reports
• Orencia: 7,533 reports
• Otezla: 137 reports
• Oxycodone: 243 reports
• Oxycontin: 166 reports
• Pantoprazole: 517 reports
• Pantoprazole sodium: 114 reports
• Paracetamol: 457 reports
• Percocet: 203 reports
• Periogard: 106 reports
• Plaquenil: 4,910 reports
• Plavix: 112 reports
• Prednisolone: 836 reports
• Prednisone: 9,611 reports
• Premarin: 267 reports
• Prempro: 120 reports
• Prevacid: 145 reports
• Prilosec: 278 reports
• Profen: 461 reports
• Prolia: 133 reports
• Protonix: 218 reports
• Prozac: 119 reports
• Ramipril: 216 reports
• Ranitidine: 120 reports
• Rebif: 193 reports
• Remicade: 8,872 reports
• Remodulin: 118 reports
• Revatio: 117 reports
• Rituxan: 2,104 reports
• Seroquel: 112 reports
• Sertraline: 121 reports
• Simponi: 3,160 reports
• Simvastatin: 176 reports
• Singulair: 225 reports
• Solu-medrol: 148 reports
• Spironolactone: 133 reports
• Stelara: 796 reports
• Sulfamethoxazole: 122 reports
• Sulfasalazine: 3,143 reports
• Symbicort: 102 reports
• Synthroid: 467 reports
• Tacrolimus: 170 reports
• Tecfidera: 108 reports
• Tegretol: 135 reports
• Tofacitinib citrate: 765 reports
• Topamax: 156 reports
• Topicort: 651 reports
• Topiramate: 103 reports
• Tracleer: 204 reports
• Tramadol: 290 reports
• Tylenol: 451 reports
• Tysabri: 153 reports
• Vicodin: 170 reports
• Vioxx: 211 reports
• Vitamin b12: 177 reports
• Vitamin c: 136 reports
• Vitamin d: 521 reports
• Vitamin d3: 669 reports
• Vitamins: 116 reports
• Voltaren: 109 reports
• Wellbutrin: 164 reports
• Xanax: 300 reports
• Xeljanz: 1,847 reports
• Xeljanz xr: 148 reports
• Xolair: 103 reports
• Xyrem: 204 reports
• Zide: 217 reports
• Zocor: 153 reports
• Zofran: 142 reports
• Zoloft: 195 reports
• Zolpidem: 105 reports
• Zyrtec: 327 reports

All the drugs that are associated with Systemic lupus erythematosus:

• Systemic lupus erythematosus (2,053 drugs)

• Acid reflux: 291 reports
• Acne: 148 reports
• Acne aggravated: 148 reports
• Acne vulgaris: 147 reports
• Adult hypothyroidism: 181 reports
• Agrypnia: 103 reports
• Alternative medicine - pain relief: 718 reports
• Ankylosing spondylitis: 348 reports
• Antidepressant therapy: 350 reports
• Anxiety: 282 reports
• Anxiety and stress: 281 reports
• Arthralgia: 158 reports
• Arthritis: 197 reports
• Arthritis - rheumatoid: 6,782 reports
• Asthma: 289 reports
• Birth control: 198 reports
• Birth control and family planning: 198 reports
• Blood cholesterol abnormal: 276 reports
• Blood cholesterol increased: 276 reports
• Blood pressure - high: 653 reports
• Blood triglycerides abnormal: 284 reports
• Blood triglycerides increased: 276 reports
• Bone and joint pain: 261 reports
• Bronchial asthma: 229 reports
• Cannot sleep: 103 reports
• Can't sleep: 103 reports
• Cataplexy: 101 reports
• Chronic asthma: 229 reports
• Colitis ulcerative: 399 reports
• Contraception: 200 reports
• Crohns: 1,372 reports
• Crohn's disease: 1,372 reports
• Crohns disease: 1,372 reports
• Daytime sleep disorder: 185 reports
• Depression: 354 reports
• Diabetes: 171 reports
• Diabetes mellitus: 171 reports
• Diabetes mellitus management: 171 reports
• Dm: 171 reports
• Dyslipidemia: 267 reports
• Epilepsy: 164 reports
• Epilepsy aggravated: 164 reports
• Feeling uptight: 233 reports
• Fibromyalgia: 218 reports
• Fibromyalgia syndrome: 218 reports
• Fibrositis: 241 reports
• Gastroesophageal reflux disease: 291 reports
• Gastro-oesophageal reflux disease: 291 reports
• Gastrooesophageal reflux disease: 291 reports
• Gerd: 291 reports
• Granulomatous ileocolitis: 1,632 reports
• Hbp: 653 reports
• Heartburn: 316 reports
• Heartburn - chronic: 282 reports
• Hidradenitis: 118 reports
• High blood cholesterol: 276 reports
• High blood cholesterol and triglycerides: 276 reports
• High blood pressure: 732 reports
• High cholesterol: 276 reports
• Hormone replacement therapy: 128 reports
• Hormone therapy: 128 reports
• Hrt: 128 reports
• Htn: 610 reports
• Hypercholesterolaemia: 290 reports
• Hyperlipidemia: 276 reports
• Hypertension: 663 reports
• Hypothyroid: 181 reports
• Hypothyroidism: 170 reports
• Hypothyroids: 181 reports
• Ileitis: 1,372 reports
• Ileitis aggravated: 1,632 reports
• Insomnia: 103 reports
• Insomnia concerns: 103 reports
• Jitters: 281 reports
• Joint aches: 261 reports
• Joint inflammation: 195 reports
• Joint pain: 158 reports
• Ldl/hdl ratio increased: 276 reports
• Lipid test: 276 reports
• Lipoprotein test: 276 reports
• Low thyroid: 170 reports
• Lupus: 2,398 reports
• Lupus erythematosus: 928 reports
• Lupus glomerular disease: 192 reports
• Lupus nephritis: 192 reports
• Migraine: 160 reports
• Migraine aggravated: 160 reports
• Migraines: 158 reports
• Ms: 823 reports
• Ms hug: 823 reports
• Multiple sclerosis: 768 reports
• Myofascial pain syndrome: 218 reports
• Narcolepsy: 185 reports
• Nephritis - lupus: 192 reports
• Osteopenia: 114 reports
• Osteoporosis: 540 reports
• Pain: 585 reports
• Pain relief by acupuncture: 580 reports
• Pimples: 149 reports
• Plaque psoriasis: 868 reports
• Pregnancy: 197 reports
• Preventive health care: 119 reports
• Primary pulmonary hypertension: 506 reports
• Psoriasis: 868 reports
• Psoriatic arthropathy: 707 reports
• Pulmonary arterial hypertension: 458 reports
• Pulmonary hypertension: 305 reports
• Pyrosis: 291 reports
• Ra: 6,782 reports
• Reflux: 282 reports
• Regional enteritis: 1,372 reports
• Rheumatoid arthritis: 6,782 reports
• Sle: 2,398 reports
• Sleep disorder: 145 reports
• Sleeping: 103 reports
• Sleeplessness: 103 reports
• Sleep - too much: 126 reports
• Spondylarthropathy: 348 reports
• Spondylitis: 348 reports
• Sporadic primary pulmonary hypertension: 473 reports
• Stiffness in a joint: 158 reports
• Stress: 281 reports
• Stress and anxiety: 377 reports
• Systemic lupus erythematosus: 1,107 reports
• Uc: 399 reports
• Ulcerative colitis: 399 reports
• Wakefulness: 103 reports
• Zits: 147 reports

All the conditions that are associated with Systemic lupus erythematosus:

• Systemic lupus erythematosus (1,423 conditions)

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