Diphenhydramine hydrochloride and Ards (acute respiratory distress syndrome) - a phase IV clinical study of FDA data

Summary:

Ards (acute respiratory distress syndrome) is found among people who take Diphenhydramine hydrochloride, especially for people who are male, 50-59 old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Diphenhydramine hydrochloride and have Ards (acute respiratory distress syndrome). It is created by eHealthMe based on reports of 14,586 people who have side effects when taking Diphenhydramine hydrochloride from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.



On Oct, 01, 2022

14,586 people reported to have side effects when taking Diphenhydramine hydrochloride.
Among them, 31 people (0.21%) have Ards (acute respiratory distress syndrome).


What is Diphenhydramine hydrochloride?

Diphenhydramine hydrochloride has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 15,975 Diphenhydramine hydrochloride users for its effectiveness, alternative drugs and more.

What is Ards (acute respiratory distress syndrome)?

Ards (acute respiratory distress syndrome) (sudden failure of the respiratory (breathing) system) is found to be associated with 2,407 drugs and 2,206 conditions by eHealthMe.

Number of Diphenhydramine hydrochloride and Ards (acute respiratory distress syndrome) reports submitted per year:

Could Diphenhydramine hydrochloride cause Ards (acute respiratory distress syndrome)?

Time on Diphenhydramine hydrochloride when people have Ards (acute respiratory distress syndrome) *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Ards (acute respiratory distress syndrome) when taking Diphenhydramine hydrochloride *:

  • female: 48 %
  • male: 52 %

Age of people who have Ards (acute respiratory distress syndrome) when taking Diphenhydramine hydrochloride *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 13.04 %
  • 20-29: 13.04 %
  • 30-39: 21.74 %
  • 40-49: 17.39 %
  • 50-59: 21.74 %
  • 60+: 13.04 %

Common drugs people take besides Diphenhydramine hydrochloride *:

  1. Acetaminophen: 9 people, 29.03%
  2. Actemra: 7 people, 22.58%
  3. Metformin: 7 people, 22.58%
  4. Methylprednisolone: 6 people, 19.35%
  5. Oxycodone: 6 people, 19.35%
  6. Valtrex: 5 people, 16.13%
  7. Pantoprazole Sodium: 5 people, 16.13%
  8. Risedronate Sodium: 5 people, 16.13%
  9. Prednisone: 5 people, 16.13%
  10. Vancomycin: 4 people, 12.90%

Common side effects people have besides Ards (acute respiratory distress syndrome) *:

  1. Hypotension (abnormally low blood pressure): 9 people, 29.03%
  2. Weakness: 9 people, 29.03%
  3. Abdominal Pain: 8 people, 25.81%
  4. Oxygen Saturation Decreased: 8 people, 25.81%
  5. Joint Swelling: 8 people, 25.81%
  6. Joint Pain: 8 people, 25.81%
  7. White Blood Cell Count Decreased: 8 people, 25.81%
  8. Infection: 7 people, 22.58%
  9. Peripheral Swelling: 7 people, 22.58%
  10. Panniculitis (inflammation of the subcutaneous fat): 7 people, 22.58%

Common conditions people have *:

  1. Polychondritis (progressive inflammation of cartilage and other connective tissue): 7 people, 22.58%
  2. Vulvovaginal Mycotic Infection (vulvovaginal fungal infection): 2 people, 6.45%
  3. Itching: 2 people, 6.45%
  4. Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 2 people, 6.45%
  5. Blood Uric Acid Increased: 2 people, 6.45%
  6. Urinary Tract Infection: 1 person, 3.23%
  7. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 3.23%
  8. Psoriasis (immune-mediated disease that affects the skin): 1 person, 3.23%
  9. Primary Amyloidosis (disease that occurs when substances called amyloid proteins build up in your organs): 1 person, 3.23%
  10. Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 1 person, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Diphenhydramine hydrochloride and have Ards (acute respiratory distress syndrome)?

Check whether Ards (acute respiratory distress syndrome) is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



Related studies

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Browse all side effects of Diphenhydramine hydrochloride:

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Ards (acute respiratory distress syndrome) treatments and more:

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All the drugs that are associated with Ards (acute respiratory distress syndrome):

Common conditions associated with Ards (acute respiratory distress syndrome):

All the conditions that are associated with Ards (acute respiratory distress syndrome):

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Diphenhydramine hydrochloride) and Diphenhydramine hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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