Divalproex and Hypoglycemia - a phase IV clinical study of FDA data


Hypoglycemia is found among people who take Divalproex, especially for people who are female, 40-49 old, have been taking the drug for 10+ years.

The phase IV clinical study analyzes which people take Divalproex and have Hypoglycemia. It is created by eHealthMe based on reports of 11,199 people who have side effects when taking Divalproex from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Mar, 28, 2023

11,199 people reported to have side effects when taking Divalproex.
Among them, 52 people (0.46%) have Hypoglycemia.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 11,711 Divalproex users for its effectiveness, alternative drugs and more.

What is Hypoglycemia?

Hypoglycemia (low blood sugar) is found to be associated with 2,878 drugs and 2,296 conditions by eHealthMe.

Number of Divalproex and Hypoglycemia reports submitted per year:

Could Divalproex cause Hypoglycemia?

Time on Divalproex when people have Hypoglycemia *:

  • < 1 month: 25 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 75 %

Gender of people who have Hypoglycemia when taking Divalproex *:

  • female: 56.86 %
  • male: 43.14 %

Age of people who have Hypoglycemia when taking Divalproex *:

  • 0-1: 4.55 %
  • 2-9: 2.27 %
  • 10-19: 2.27 %
  • 20-29: 15.91 %
  • 30-39: 15.91 %
  • 40-49: 27.27 %
  • 50-59: 15.91 %
  • 60+: 15.91 %

Common drugs people take besides Divalproex *:

  1. Zyprexa: 11 people, 21.15%
  2. Metformin: 7 people, 13.46%
  3. Simvastatin: 6 people, 11.54%
  4. Sertraline: 5 people, 9.62%
  5. Aripiprazole: 5 people, 9.62%
  6. Levetiracetam: 5 people, 9.62%
  7. Mirtazapine: 5 people, 9.62%
  8. Zenpep: 4 people, 7.69%
  9. Phenytoin: 4 people, 7.69%
  10. Nexium: 4 people, 7.69%

Common side effects people have besides Hypoglycemia *:

  1. Diabetes: 8 people, 15.38%
  2. Hypotension (abnormally low blood pressure): 7 people, 13.46%
  3. High Blood Cholesterol: 7 people, 13.46%
  4. Overdose: 7 people, 13.46%
  5. Stress And Anxiety: 6 people, 11.54%
  6. Consciousness - Decreased: 5 people, 9.62%
  7. High Blood Pressure: 5 people, 9.62%
  8. Sepsis (a severe blood infection that can lead to organ failure and death): 5 people, 9.62%
  9. Pneumonia: 5 people, 9.62%
  10. Respiratory Depression (respiration has a rate below 12 breaths): 5 people, 9.62%

Common conditions people have *:

  1. Depression: 8 people, 15.38%
  2. High Blood Pressure: 6 people, 11.54%
  3. Type 2 Diabetes: 6 people, 11.54%
  4. High Blood Cholesterol: 5 people, 9.62%
  5. Stress And Anxiety: 5 people, 9.62%
  6. Affective Disorder (mental disorder): 4 people, 7.69%
  7. Overdose: 4 people, 7.69%
  8. Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 3 people, 5.77%
  9. Erection Problems: 3 people, 5.77%
  10. Insomnia (sleeplessness): 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

Do you take Divalproex and have Hypoglycemia?

Check whether Hypoglycemia is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Hypoglycemia and when was it recovered:

Expand to all the drugs that have ingredients of divalproex sodium:

Alternative drugs to, pros and cons of Divalproex:

Common Divalproex side effects:

Browse all side effects of Divalproex:

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Hypoglycemia treatments and more:

COVID vaccines that are related to Hypoglycemia:

Common drugs associated with Hypoglycemia:

All the drugs that are associated with Hypoglycemia:

Common conditions associated with Hypoglycemia:

All the conditions that are associated with Hypoglycemia:

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Divalproex) and Divalproex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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