Doxil and Mental status changes - a phase IV clinical study of FDA data


Mental status changes is found among people who take Doxil, especially for people who are female, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Doxil and have Mental status changes. It is created by eHealthMe based on reports of 10,200 people who have side effects when taking Doxil from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 03, 2023

10,200 people reported to have side effects when taking Doxil.
Among them, 83 people (0.81%) have Mental status changes.

What is Doxil?

Doxil has active ingredients of doxorubicin hydrochloride. It is often used in ovarian cancer. eHealthMe is studying from 10,253 Doxil users for its effectiveness, alternative drugs and more.

What is Mental status changes?

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation) is found to be associated with 2,310 drugs and 1,633 conditions by eHealthMe.

Number of Doxil and Mental status changes reports submitted per year:

Could Doxil cause Mental status changes?

Time on Doxil when people have Mental status changes *:

  • < 1 month: 60 %
  • 1 - 6 months: 40 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Mental status changes when taking Doxil *:

  • female: 70.37 %
  • male: 29.63 %

Age of people who have Mental status changes when taking Doxil *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 1.54 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 20.0 %
  • 50-59: 32.31 %
  • 60+: 46.15 %

Common drugs people take besides Doxil *:

  1. Zometa: 35 people, 42.17%
  2. Decadron: 25 people, 30.12%
  3. Xeloda: 24 people, 28.92%
  4. Compazine: 24 people, 28.92%
  5. Ativan: 24 people, 28.92%
  6. Aredia: 23 people, 27.71%
  7. Lovenox: 23 people, 27.71%
  8. Taxotere: 21 people, 25.30%
  9. Coumadin: 21 people, 25.30%
  10. Vicodin: 20 people, 24.10%

Common side effects people have besides Mental status changes *:

  1. Fatigue (feeling of tiredness): 39 people, 46.99%
  2. Fever: 38 people, 45.78%
  3. Weakness: 35 people, 42.17%
  4. Stress And Anxiety: 35 people, 42.17%
  5. Breathing Difficulty: 32 people, 38.55%
  6. General Physical Health Deterioration (weak health status): 30 people, 36.14%
  7. Osteonecrosis Of Jaw (death of bone of jaw): 30 people, 36.14%
  8. Pain: 29 people, 34.94%
  9. High Blood Pressure: 29 people, 34.94%
  10. Pneumonia: 28 people, 33.73%

Common conditions people have *:

  1. Multiple Myeloma (cancer of the plasma cells): 24 people, 28.92%
  2. Depression: 10 people, 12.05%
  3. Insomnia (sleeplessness): 9 people, 10.84%
  4. Muscle Spasms (muscle contraction): 9 people, 10.84%
  5. Upper Respiratory Tract Infection: 9 people, 10.84%
  6. Sleep Disorder: 9 people, 10.84%
  7. Pain: 9 people, 10.84%
  8. Mood Swings (an extreme or rapid change in mood): 9 people, 10.84%
  9. Breathing Difficulty: 9 people, 10.84%
  10. Metastases To Bone (cancer spreads to bone): 7 people, 8.43%

* Approximation only. Some reports may have incomplete information.

Do you take Doxil and have Mental status changes?

Check whether Mental status changes is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Mental status changes and when was it recovered:

Expand to all the drugs that have ingredients of doxorubicin hydrochloride:

Alternative drugs to, pros and cons of Doxil:

Common Doxil side effects:

Browse all side effects of Doxil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Mental status changes treatments and more:

COVID vaccines that are related to Mental status changes:

Common drugs associated with Mental status changes:

All the drugs that are associated with Mental status changes:

Common conditions associated with Mental status changes:

All the conditions that are associated with Mental status changes:

How the study uses the data?

The study uses data from the FDA. It is based on doxorubicin hydrochloride (the active ingredients of Doxil) and Doxil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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