Doxycycline and Lymphocytosis - a phase IV clinical study of FDA data


Lymphocytosis is found among people who take Doxycycline, especially for people who are male, 30-39 old.

The phase IV clinical study analyzes which people take Doxycycline and have Lymphocytosis. It is created by eHealthMe based on reports of 53,763 people who have side effects when taking Doxycycline from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Nov, 30, 2022

53,763 people reported to have side effects when taking Doxycycline.
Among them, 10 people (0.02%) have Lymphocytosis.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 56,940 Doxycycline users for its effectiveness, alternative drugs and more.

What is Lymphocytosis?

Lymphocytosis (an increase in the number or proportion of lymphocytes in the blood) is found to be associated with 779 drugs and 470 conditions by eHealthMe.

Number of Doxycycline and Lymphocytosis reports submitted per year:

Could Doxycycline cause Lymphocytosis?

Gender of people who have Lymphocytosis when taking Doxycycline *:

  • female: 22.22 %
  • male: 77.78 %

Age of people who have Lymphocytosis when taking Doxycycline *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 42.86 %
  • 30-39: 42.86 %
  • 40-49: 14.29 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Common drugs people take besides Doxycycline *:

  1. Xanax: 4 people, 40.00%
  2. Lisinopril: 4 people, 40.00%
  3. Flexeril: 4 people, 40.00%
  4. Ultram: 4 people, 40.00%
  5. Neurontin: 4 people, 40.00%
  6. Zoloft: 3 people, 30.00%
  7. Ergocalciferol: 3 people, 30.00%
  8. Phoslo: 3 people, 30.00%
  9. Lopressor: 3 people, 30.00%
  10. Hydromorphone Hydrochloride: 3 people, 30.00%

Common side effects people have besides Lymphocytosis *:

  1. Fever: 8 people, 80.00%
  2. Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 5 people, 50.00%
  3. Back Pain: 5 people, 50.00%
  4. Dizziness: 4 people, 40.00%
  5. Malaise (a feeling of general discomfort or uneasiness): 4 people, 40.00%
  6. Leukopenia (less number of white blood cells in blood): 4 people, 40.00%
  7. Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 4 people, 40.00%
  8. Leukocytosis (increased white blood cells): 4 people, 40.00%
  9. Diarrhea: 4 people, 40.00%
  10. Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 4 people, 40.00%

Common conditions people have *:

  1. Tenosynovitis (inflammation of the fluid-filled sheath (called the synovium) that surrounds a tendon): 3 people, 30.00%
  2. Headache (pain in head): 2 people, 20.00%
  3. Sleep Disorder: 1 person, 10.00%
  4. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 10.00%
  5. Pain: 1 person, 10.00%
  6. Nausea (feeling of having an urge to vomit): 1 person, 10.00%
  7. Muscle Spasms (muscle contraction): 1 person, 10.00%
  8. Insomnia (sleeplessness): 1 person, 10.00%
  9. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 10.00%
  10. Cardiac Disorder: 1 person, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Doxycycline and have Lymphocytosis?

Check whether Lymphocytosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Lymphocytosis and when was it recovered:

Expand to all the drugs that have ingredients of doxycycline hyclate:

Alternative drugs to, pros and cons of Doxycycline:

Common Doxycycline side effects:

Browse all side effects of Doxycycline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Lymphocytosis treatments and more:

COVID vaccines that are related to Lymphocytosis:

Common drugs associated with Lymphocytosis:

All the drugs that are associated with Lymphocytosis:

Common conditions associated with Lymphocytosis:

All the conditions that are associated with Lymphocytosis:

How the study uses the data?

The study uses data from the FDA. It is based on doxycycline hyclate (the active ingredients of Doxycycline) and Doxycycline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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