Duopa and Headache - a phase IV clinical study of FDA data


Headache is found among people who take Duopa, especially for people who are male, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Duopa and have Headache. It is created by eHealthMe based on reports of 5,825 people who have side effects when taking Duopa from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Mar, 24, 2023

5,825 people reported to have side effects when taking Duopa.
Among them, 39 people (0.67%) have Headache.

What is Duopa?

Duopa has active ingredients of carbidopa; levodopa. eHealthMe is studying from 5,827 Duopa users for its effectiveness, alternative drugs and more.

What is Headache?

Headache (pain in head) is found to be associated with 5,241 drugs and 5,618 conditions by eHealthMe.

Number of Duopa and Headache reports submitted per year:

Could Duopa cause Headache?

Time on Duopa when people have Headache *:

  • < 1 month: 33.33 %
  • 1 - 6 months: 16.67 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 16.67 %
  • 2 - 5 years: 33.33 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Headache when taking Duopa *:

  • female: 34.21 %
  • male: 65.79 %

Age of people who have Headache when taking Duopa *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 20.83 %
  • 60+: 79.17 %

Common drugs people take besides Duopa *:

  1. Sinemet: 15 people, 38.46%
  2. Mirapex: 9 people, 23.08%
  3. Amlodipine: 7 people, 17.95%
  4. Miralax: 6 people, 15.38%
  5. Oxycodone And Acetaminophen: 6 people, 15.38%
  6. Sertraline: 6 people, 15.38%
  7. Carbidopa, Levodopa And Entacapone: 5 people, 12.82%
  8. Vitamin C: 4 people, 10.26%
  9. Vitamin B12: 4 people, 10.26%
  10. Pantoprazole: 4 people, 10.26%

Common side effects people have besides Headache *:

  1. Fall: 11 people, 28.21%
  2. Device Occlusion: 9 people, 23.08%
  3. Fatigue (feeling of tiredness): 9 people, 23.08%
  4. Device Dislocation: 6 people, 15.38%
  5. Abdominal Pain Lower: 6 people, 15.38%
  6. Head Injury: 6 people, 15.38%
  7. Pain In Extremity: 5 people, 12.82%
  8. Pain: 5 people, 12.82%
  9. Memory Loss: 5 people, 12.82%
  10. Hypoaesthesia (reduced sense of touch or sensation): 5 people, 12.82%

Common conditions people have *:

  1. Parkinson's Disease: 24 people, 61.54%
  2. High Blood Pressure: 7 people, 17.95%
  3. Depression: 6 people, 15.38%
  4. High Blood Cholesterol: 4 people, 10.26%
  5. Constipation: 4 people, 10.26%
  6. Dementia (madness): 4 people, 10.26%
  7. Dyskinesia (abnormality or impairment of voluntary movement): 4 people, 10.26%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 10.26%
  9. Muscle Spasms (muscle contraction): 3 people, 7.69%
  10. Stress And Anxiety: 3 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Duopa and have Headache?

Check whether Headache is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Headache and when was it recovered:

Expand to all the drugs that have ingredients of carbidopa; levodopa:

Alternative drugs to, pros and cons of Duopa:

Common Duopa side effects:

Browse all side effects of Duopa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Headache treatments and more:

COVID vaccines that are related to Headache:

Common drugs associated with Headache:

All the drugs that are associated with Headache:

Common conditions associated with Headache:

All the conditions that are associated with Headache:

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa (the active ingredients of Duopa) and Duopa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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