Duragesic-100 and Dupuytren's contracture - a phase IV clinical study of FDA data

• Duragesic-100 (19,508 reports)

• Abdominal discomfort: 108 reports
• Abdominal distension: 110 reports
• Abdominal pain: 560 reports
• Abdominal pain upper: 213 reports
• Accidental overdose (therapeutic agent): 128 reports
• Acute kidney failure: 380 reports
• Adverse event: 139 reports
• Agitation (state of anxiety or nervous excitement): 280 reports
• Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 223 reports
• Anaemia (lack of blood): 766 reports
• Anhedonia (inability to experience pleasure from activities usually found enjoyable): 263 reports
• Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight): 163 reports
• Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 347 reports
• Application site erythema (redness of the skin at application site): 280 reports
• Application site irritation: 211 reports
• Application site pruritus (application site severe itching of the skin): 243 reports
• Application site rash: 274 reports
• Application site reaction: 211 reports
• Arrhythmias (irregular heartbeat): 256 reports
• Arthritis (form of joint disorder that involves inflammation of one or more joints): 249 reports
• Arthropathy: 171 reports
• Aseptic necrosis (the death of bone tissue due to a lack of blood supply): 404 reports
• Asthma: 171 reports
• Atelectasis (partial or complete collapse of the lung): 209 reports
• Atherosclerosis (disorder of the arteries): 158 reports
• Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 216 reports
• Back disorder: 133 reports
• Back pain: 1,000 reports
• Balance disorder: 175 reports
• Blood alkaline phosphatase increased: 110 reports
• Blood creatinine increased: 179 reports
• Blood glucose increased: 204 reports
• Blood potassium decreased: 122 reports
• Body height decreased: 124 reports
• Bone disorder: 511 reports
• Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries): 252 reports
• Bone pain: 295 reports
• Breakthrough pain: 329 reports
• Breathing difficulty: 1,075 reports
• Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 298 reports
• Cardiac arrest: 167 reports
• Cardiac disorder: 175 reports
• Cardiac failure congestive: 254 reports
• Cataract (clouding of the lens inside the eye): 104 reports
• Cellulitis (infection under the skin): 286 reports
• Chest pain: 714 reports
• Chills (felling of cold): 259 reports
• Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 308 reports
• Compression fracture (fracture due to pressure caused by injury): 137 reports
• Confusion: 180 reports
• Confusional state: 617 reports
• Consciousness - decreased: 311 reports
• Constipation: 783 reports
• Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 409 reports
• Coronary heart disease (narrowing or blockage of the coronary arteries): 203 reports
• Cough: 244 reports
• Coughing up blood: 121 reports
• Cuts and puncture wounds: 105 reports
• Death: 742 reports
• Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 329 reports
• Deformity (disfigurement): 182 reports
• Dehydration (dryness resulting from the removal of water): 560 reports
• Delirium (wild excitement): 115 reports
• Dental caries: 289 reports
• Depressed level of consciousness: 163 reports
• Depression: 1,017 reports
• Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens): 199 reports
• Device failure: 161 reports
• Diabetes: 258 reports
• Diarrhea: 785 reports
• Disability: 116 reports
• Disease progression: 210 reports
• Disturbance in attention: 136 reports
• Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body): 141 reports
• Dizziness: 905 reports
• Drowsiness: 895 reports
• Drug abuse and dependence: 237 reports
• Drug administration error: 267 reports
• Drug dependence: 215 reports
• Drug effect decreased: 434 reports
• Drug ineffective: 1,615 reports
• Drug toxicity: 454 reports
• Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 295 reports
• Dry mouth: 195 reports
• Dyskinesia (abnormality or impairment of voluntary movement): 130 reports
• Dyspnea exertional: 117 reports
• Ear pain: 115 reports
• Eating disorder: 128 reports
• Emotional distress: 218 reports
• Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 153 reports
• Enlarged heart: 187 reports
• Exostosis (formation of new bone on the surface of a bone): 150 reports
• Exposed bone in jaw: 105 reports
• Fainting (loss of consciousness and postural tone): 218 reports
• Fall: 1,030 reports
• Fatigue (feeling of tiredness): 1,004 reports
• Fever: 723 reports
• Fibromyalgia (a long-term condition which causes pain all over the body): 123 reports
• Foot fracture: 120 reports
• Fungal infection: 104 reports
• Gait disturbance: 338 reports
• Gallstones (stone formation by bile component): 128 reports
• Gastric ulcer (stomach ulcer): 196 reports
• Gastritis (inflammation of stomach): 182 reports
• Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 419 reports
• Gastrointestinal haemorrhage (bleeding gastrointestinal tract): 212 reports
• General physical health deterioration (weak health status): 438 reports
• Haematochezia (passage of stools containing blood): 139 reports
• Haematuria (presence of blood in urine): 121 reports
• Haemoglobin decreased: 222 reports
• Haemorrhage (bleeding): 123 reports
• Haemorrhoids (a swollen vein or group of veins in the region of the anus): 147 reports
• Hair loss: 104 reports
• Hallucinations (sensations that appear real but are created by your mind): 197 reports
• Headache (pain in head): 780 reports
• Head injury: 285 reports
• Heart attack: 409 reports
• Heart palpitations (feelings or sensations that your heart is pounding or racing): 194 reports
• Heart rate increased: 128 reports
• Herpes zoster: 143 reports
• Hiatal hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 196 reports
• High blood cholesterol: 396 reports
• High blood pressure: 922 reports
• Hip fracture: 113 reports
• Hospitalisation: 187 reports
• Hot flush (sudden feelings of heat): 183 reports
• Hyperglycemia (high blood sugar): 103 reports
• Hyperhidrosis (abnormally increased sweating): 908 reports
• Hyperkalemia (damage to or disease of the kidney): 118 reports
• Hyperlipidaemia (presence of excess lipids in the blood): 128 reports
• Hypersensitivity: 128 reports
• Hypoaesthesia (reduced sense of touch or sensation): 426 reports
• Hypokalemia (low potassium): 292 reports
• Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 190 reports
• Hypophagia (reduced food intake): 123 reports
• Hypotension (abnormally low blood pressure): 472 reports
• Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 130 reports
• Impaired healing: 305 reports
• Indigestion: 224 reports
• Infection: 406 reports
• Inflammation: 161 reports
• Influenza like illness: 107 reports
• Injury: 487 reports
• Insomnia (sleeplessness): 735 reports
• Intervertebral disc degeneration (spinal disc degeneration): 213 reports
• Intervertebral disc protrusion (spinal disc protrusion): 398 reports
• Intestinal obstruction: 190 reports
• Itching: 294 reports
• Jaw disorder (jaw disease): 121 reports
• Joint pain: 598 reports
• Joint swelling: 115 reports
• Kidney stones: 139 reports
• Leukopenia (less number of white blood cells in blood): 177 reports
• Loose tooth: 136 reports
• Loss of consciousness: 436 reports
• Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung): 112 reports
• Lung neoplasm (tumour of lung): 116 reports
• Lymph follicular hypertrophy (an increase in the size of the lymph node follicles): 158 reports
• Malaise (a feeling of general discomfort or uneasiness): 600 reports
• Malignant neoplasm progression (cancer tumour came back): 312 reports
• Malnutrition (condition that results from eating a diet in which certain nutrients are lacking): 116 reports
• Memory loss: 458 reports
• Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 171 reports
• Metastases to bone (cancer spreads to bone): 292 reports
• Migraine (headache): 203 reports
• Mouth ulcers: 153 reports
• Mucosal inflammation (infection of mucous membrane): 122 reports
• Multiple myeloma (cancer of the plasma cells): 169 reports
• Muscle aches (muscle pain): 228 reports
• Muscle spasms (muscle contraction): 462 reports
• Musculoskeletal chest pain (pain in chest muscle or nerve or bones): 112 reports
• Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 145 reports
• Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 127 reports
• Narcotic intoxication (a condition caused by use of narcotic agents): 125 reports
• Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 103 reports
• Nausea (feeling of having an urge to vomit): 1,725 reports
• Nausea and vomiting: 1,445 reports
• Neck pain: 284 reports
• Neoplasm malignant (cancer tumour): 224 reports
• Nervousness: 151 reports
• Neuralgia (pain in one or more nerves): 156 reports
• Neuropathy peripheral (surface nerve damage): 302 reports
• Night sweats (sweating in night): 125 reports
• Nosebleed (bleeding from nose): 128 reports
• Oedema (fluid collection in tissue): 151 reports
• Oedema peripheral (superficial swelling): 544 reports
• Oesophagitis (inflammation of oesophagus): 133 reports
• Oral pain: 153 reports
• Oropharyngeal pain: 113 reports
• Osteoarthritis (a joint disease caused by cartilage loss in a joint): 454 reports
• Osteomyelitis (infection of bone): 414 reports
• Osteonecrosis of jaw (death of bone of jaw): 564 reports
• Osteopenia (a condition where bone mineral density is lower than normal): 172 reports
• Osteoporosis (bones weak and more likely to break): 248 reports
• Overdose: 703 reports
• Pain: 2,169 reports
• Pain in extremity: 591 reports
• Pain in jaw: 418 reports
• Pancreatitis (inflammation of pancreas): 114 reports
• Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 168 reports
• Panic disorder: 120 reports
• Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 263 reports
• Pathological fracture (broken bone caused by disease): 120 reports
• Pleural effusion (water on the lungs): 355 reports
• Pneumonia: 831 reports
• Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 124 reports
• Primary sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone): 144 reports
• Pulmonary embolism (blockage of the main artery of the lung): 270 reports
• Pulmonary oedema (fluid accumulation in the lungs): 144 reports
• Rashes (redness): 630 reports
• Rectal haemorrhage (bleeding from anus): 169 reports
• Renal failure acute (rapid kidney dysfunction): 293 reports
• Renal failure chronic (long lasting kidney dysfunction): 124 reports
• Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 362 reports
• Respiratory depression (respiration has a rate below 12 breaths): 186 reports
• Respiratory distress (difficulty in breathing): 104 reports
• Restless leg syndrome (a powerful urge to move your legs): 104 reports
• Rib fracture: 184 reports
• Road traffic accident: 274 reports
• Sedation: 106 reports
• Sepsis (a severe blood infection that can lead to organ failure and death): 227 reports
• Sinusitis (inflammation of sinus): 197 reports
• Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 136 reports
• Sleep apnea syndrome: 105 reports
• Sleep disorder: 105 reports
• Speech impairment (adult) (inability to speak (adult)): 185 reports
• Spinal osteoarthritis (joint cartilage loss in spine): 258 reports
• Stable angina (a constant chest pain): 101 reports
• Staphylococcal infection (an infection with staphylococcus bacteria): 144 reports
• Stomatitis (inflammation of mucous membrane of mouth): 180 reports
• Stress and anxiety: 1,211 reports
• Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 337 reports
• Suicidal ideation: 198 reports
• Suicide attempt: 114 reports
• Surgery: 153 reports
• Swallowing difficulty: 364 reports
• Swelling: 361 reports
• Swelling face: 121 reports
• Taste - impaired: 126 reports
• Tenderness (pain or discomfort when an affected area is touched): 123 reports
• Therapeutic response decreased (less preventive response): 415 reports
• Thrombocytopenia (decrease of platelets in blood): 422 reports
• Thrombosis (formation of a blood clot inside a blood vessel): 145 reports
• Tooth abscess (pus formation in tooth): 213 reports
• Toothaches (tooth pain): 141 reports
• Tooth disorder (tooth disease): 138 reports
• Tooth extraction: 405 reports
• Tooth loss: 158 reports
• Tremor (trembling or shaking movements in one or more parts of your body): 397 reports
• Tumor: 102 reports
• Unresponsive to stimuli: 115 reports
• Upper respiratory tract infection: 145 reports
• Urinary incontinence (inability to control the flow of urine and involuntary urination): 129 reports
• Urinary retention (the inability to completely or partially empty the bladder): 123 reports
• Urinary tract infection: 419 reports
• Urination - painful: 190 reports
• Vision blurred: 228 reports
• Weakness: 979 reports
• Weight decreased: 901 reports
• Weight increased: 326 reports
• White blood cell count decreased: 125 reports
• Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 807 reports

• Dupuytren's contracture (2,031 reports)

All the drugs that are associated with Dupuytren's contracture:

• Dupuytren's contracture (445 drugs)

All the conditions that are associated with Dupuytren's contracture:

• Dupuytren's contracture (208 conditions)

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