Who have Osteonecrosis with Efavirenz - from FDA reports


Osteonecrosis is found among people who take Efavirenz, especially for people who are male, 30-39 old , have been taking the drug for 6 - 12 months, also take medication Didanosine, and have Hepatitis c. This study is created by eHealthMe based on reports of 10,308 people who have side effects when taking Efavirenz from FDA, and is updated regularly.

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On Dec, 06, 2018

10,308 people reported to have side effects when taking Efavirenz.
Among them, 58 people (0.56%) have Osteonecrosis


Number of reports submitted per year:

Could Efavirenz cause Osteonecrosis?

Time on Efavirenz when people have Osteonecrosis *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 6.25 %
  • 6 - 12 months: 43.75 %
  • 1 - 2 years: 37.5 %
  • 2 - 5 years: 12.5 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Osteonecrosis when taking Efavirenz *:

  • female: 9.09 %
  • male: 90.91 %

Age of people who have Osteonecrosis when taking Efavirenz *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 4.55 %
  • 30-39: 56.82 %
  • 40-49: 18.18 %
  • 50-59: 18.18 %
  • 60+: 2.27 %

Top conditions involved for these people *:

  1. Hepatitis C: 5 people, 8.62%
  2. Diarrhea: 3 people, 5.17%
  3. Metastases To Bone (cancer spreads to bone): 2 people, 3.45%
  4. Acquired Immunodeficiency Syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv)): 2 people, 3.45%
  5. Weight Decreased: 1 person, 1.72%

Click here to view more results or personalize the results to your gender and age

Top co-used drugs for these people *:

  1. Didanosine: 29 people, 50.00%
  2. Lamivudine: 25 people, 43.10%
  3. Stavudine: 21 people, 36.21%
  4. Zidovudine: 17 people, 29.31%
  5. Tenofovir Disoproxil Fumarate: 13 people, 22.41%

Click here to view more results or personalize the results to your gender and age

Top other side effects for these people *:

  1. Rashes (redness): 8 people, 13.79%
  2. Thrombocytopenia (decrease of platelets in blood): 8 people, 13.79%
  3. Hyperlactacidaemia (the acidosis and also reduces the capacity of the kidney): 7 people, 12.07%
  4. Treatment Failure: 7 people, 12.07%
  5. Cachexia (loss of weight): 7 people, 12.07%

Click here to view more results or personalize the results to your gender and age

* Approximation only. Some reports may have incomplete information.

FDA reports used in this study



Do you have Osteonecrosis while taking Efavirenz?


You are not alone:




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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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