Efavirenz and Sick sinus syndrome - a phase IV clinical study of FDA data

Summary:

Sick sinus syndrome is found among people who take Efavirenz, especially for people who are male, 50-59 old, have been taking the drug for 5 - 10 years.

The phase IV clinical study analyzes which people take Efavirenz and have Sick sinus syndrome. It is created by eHealthMe based on reports of 13,366 people who have side effects when taking Efavirenz from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.



On Jul, 02, 2022

13,366 people reported to have side effects when taking Efavirenz.
Among them, 9 people (0.07%) have Sick sinus syndrome.


What is Efavirenz?

Efavirenz has active ingredients of efavirenz. It is often used in hiv infection. eHealthMe is studying from 14,173 Efavirenz users for its effectiveness, alternative drugs and more.

What is Sick sinus syndrome?

Sick sinus syndrome (a collection of heart rhythm disorders) is found to be associated with 1,264 drugs and 721 conditions by eHealthMe.

Number of Efavirenz and Sick sinus syndrome reports submitted per year:

Could Efavirenz cause Sick sinus syndrome?

Time on Efavirenz when people have Sick sinus syndrome *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 20 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 80 %
  • 10+ years: 0.0 %

Gender of people who have Sick sinus syndrome when taking Efavirenz *:

  • female: 0.0 %
  • male: 100 %

Age of people who have Sick sinus syndrome when taking Efavirenz *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 40 %
  • 40-49: 0.0 %
  • 50-59: 60 %
  • 60+: 0.0 %

Common drugs people take besides Efavirenz *:

  1. Kaletra: 9 people, 100.00%
  2. Lamivudine: 7 people, 77.78%
  3. Bactrim: 7 people, 77.78%
  4. Didanosine: 7 people, 77.78%
  5. Abacavir: 6 people, 66.67%
  6. Norvir: 5 people, 55.56%
  7. Stavudine: 5 people, 55.56%
  8. Viread: 4 people, 44.44%
  9. Hydrocortisone: 4 people, 44.44%
  10. Clarithromycin: 4 people, 44.44%

Common side effects people have besides Sick sinus syndrome *:

  1. Blood Amylase Increased: 5 people, 55.56%
  2. Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 5 people, 55.56%
  3. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 5 people, 55.56%
  4. Necrosis (the death of body tissue): 5 people, 55.56%
  5. Central Nervous System Lymphoma (cancer of central nervous system forms in lymph tissue): 5 people, 55.56%
  6. Cerebral Haemorrhage (bleeding within the brain): 5 people, 55.56%
  7. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 55.56%
  8. Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 55.56%
  9. Hyperglycemia (high blood sugar): 5 people, 55.56%
  10. Disease Recurrence: 5 people, 55.56%

Common conditions people have *:

  1. Adrenal Insufficiency (condition in which the adrenal glands do not produce adequate amounts of steroids): 3 people, 33.33%
  2. The Flu (the flu is caused by an influenza virus): 2 people, 22.22%
  3. Mycobacterium Avium Complex Infection: 2 people, 22.22%
  4. Insomnia (sleeplessness): 2 people, 22.22%
  5. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 22.22%

* Approximation only. Some reports may have incomplete information.

Do you take Efavirenz and have Sick sinus syndrome?

Check whether Sick sinus syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



Related studies

How severe was Sick sinus syndrome and when was it recovered:

Expand to all the drugs that have ingredients of efavirenz:

Alternative drugs to, pros and cons of Efavirenz:

Common Efavirenz side effects:

Browse all side effects of Efavirenz:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sick sinus syndrome treatments and more:

COVID vaccines that are related to Sick sinus syndrome:

Common drugs associated with Sick sinus syndrome:

All the drugs that are associated with Sick sinus syndrome:

Common conditions associated with Sick sinus syndrome:

All the conditions that are associated with Sick sinus syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on efavirenz (the active ingredients of Efavirenz) and Efavirenz (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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